Journal
NANOMATERIALS
Volume 12, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/nano12183183
Keywords
drug delivery systems; redox-responsive; reducing; linkers; bonds
Categories
Funding
- American University of Sharjah Faculty Research Grants
- Al-Jalila Foundation [AJF 2015555]
- Al Qasimi Foundation
- Patient's Friends Committee-Sharjah
- Biosciences and Bioengineering Research Institute [BBRI18-CEN-11]
- GCC Co-Fund Program [IRF17-003]
- Takamul program [POC-00028-18]
- Technology Innovation Pioneer (TIP) Healthcare Awards
- Sheikh Hamdan Award for Medical Sciences [MRG/18/2020]
- Friends of Cancer Patients (FoCP)
- Dana Gas Endowed Chair for Chemical Engineering
- Open Access Program from the American University of Sharjah [OAPCEN-1410-E00087]
Ask authors/readers for more resources
This paper explores the physiological and biochemical basis of redox-responsive drug delivery systems as a potential cancer treatment, and reviews recent advances in the chemical composition and design of these systems. It discusses five main redox-responsive chemical entities, focusing on the most commonly used disulfide bonds and their incorporation into liposomes, polymeric micelles, and nanogels.
With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redox-responsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and enhanced site-specific targeted delivery. This paper explores the physiological and biochemical nature of tumors that allow for redox-responsive drug delivery systems and reviews recent advances in the chemical composition and design of such systems. The five main redox-responsive chemical entities that are the focus of this paper are disulfide bonds, diselenide bonds, succinimide-thioether linkages, tetrasulfide bonds, and platin conjugates. Moreover, as disulfide bonds are the most commonly used entities, the review explored disulfide-containing liposomes, polymeric micelles, and nanogels. While various systems have been devised, further research is needed to advance redox-responsive drug delivery systems for cancer treatment clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available