LncRNAs regulate ferroptosis to affect diabetes and its complications

Letter Medicine, General & Internal

lncRNA-Gm4419 alleviates renal damage in rats with diabetic nephropathy through NF-kappa B pathway

Haizhen Li et al.

PANMINERVA MEDICA (2023)

Review Biochemistry & Molecular Biology

Non-coding RNAs and type 2 diabetes mellitus

Mohammad Taheri et al.

Summary: Certain miRNAs and lncRNAs play important roles in the pathogenesis of type 2 diabetes and can be used as markers or therapeutic molecules.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Genetics & Heredity

Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis

Ting Li et al.

Summary: Res has been shown to protect against myocardial I/R injury by reducing oxidative stress and inhibiting ferroptosis, potentially through the regulation of USP19-Beclin1 autophagy.

GENE (2022)

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Article Biochemistry & Molecular Biology

High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis

Yaoqi Li et al.

Summary: This study successfully established a zebrafish larvae model of diabetes and identified differentially expressed genes related to the apoptosis pathway through transcriptome analysis. Further experiments measured glucose-induced developmental toxicity, reactive oxygen species accumulation, antioxidant system function, apoptosis, and mitochondrial dysfunction in zebrafish larvae. These findings provide valuable reference information for the treatment of type 2 juvenile diabetes.

APOPTOSIS (2022)

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Article Environmental Sciences

Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction

Meng-Die Li et al.

Summary: This study found that dysfunction of mitochondria-associated endoplasmic reticulum membrane (MAMs) is involved in arsenic-induced pulmonary ferroptosis and acute lung injury (ALI).

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Review Nutrition & Dietetics

Ferroptosis Regulation by Nutrient Signalling

Yingao Qi et al.

Summary: Recent progress in the field of ferroptosis has highlighted the intricate relationship between nutrient signals and cell death processes, offering new insights into the roles of cell death in normal physiology and disease development.

NUTRITION RESEARCH REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer

Lv Yang et al.

Summary: This study identified CUL9 as a novel regulator of ferroptosis in colorectal cancer (CRC) and revealed its association with drug resistance. It provides a new target to overcome drug resistance to ferroptosis activators and suggests targeting MDM2 as a potential strategy for treating drug-resistant CRC cells.

ONCOGENE (2022)

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Article Medicine, Research & Experimental

Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy

Ziyang Wang et al.

Summary: In this study, the researchers found that the long non-coding RNA MIAT was significantly upregulated in patients with diabetic nephropathy and was associated with kidney dysfunction. Further experiments revealed that depletion of MIAT could restore podocyte structure and function, and inhibit mitotic catastrophe. Mechanistically, MIAT was found to regulate key molecules including Sox4 and p53, and interact with miR-130b-3p.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Biotechnology & Applied Microbiology

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

Jinzhong Huang et al.

Summary: This study found that Platycodin D (PD) inhibited ferroptosis in high glucose-induced HK-2 cells by upregulating GPX4 expression. This suggests that PD may be an effective drug for the clinical treatment of diabetic nephropathy.

BIOENGINEERED (2022)

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Review Endocrinology & Metabolism

Ferroptosis and ferritinophagy in diabetes complications

Jiahui He et al.

Summary: This review systematically explores the roles and regulatory mechanisms of ferroptosis and ferritinophagy in diabetes complications and highlights their potential therapeutic value. However, further research is needed to fully understand their molecular mechanisms and pathophysiological processes involved.

MOLECULAR METABOLISM (2022)

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Review Endocrinology & Metabolism

Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

Xi-Ding Yang et al.

Summary: This review summarizes the role and regulatory mechanisms of ferroptosis in diabetes and its complications, as well as the inhibitors of ferroptosis in diabetes and diabetic complications. Understanding the regulation of ferroptosis and developing drugs targeting ferroptosis may provide new treatment strategies for patients with diabetes.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Biochemistry & Molecular Biology

ZIP14 is involved in iron deposition and triggers ferroptosis in diabetic nephropathy

Keping Wu et al.

Summary: The study reveals the important role of ZIP14 in ferroptosis-mediated diabetic kidney injury, showing that it can improve kidney function by regulating ferrous iron and oxidative stress levels, providing a potential new therapeutic approach for the treatment of diabetic nephropathy.

METALLOMICS (2022)

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Article Cell & Tissue Engineering

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Yiqi Yang et al.

Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.

BONE RESEARCH (2022)

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Review Cell Biology

Ferroptosis: machinery and regulation

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.

AUTOPHAGY (2021)

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Article Endocrinology & Metabolism

Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy

Rakesh Radhakrishnan et al.

Summary: This study demonstrates that LncRNA MALAT1 plays a role in regulating antioxidant defense in diabetic retinopathy via the Keap1-Nrf2 pathway.

DIABETES (2021)

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Article Dermatology

miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes

Dongqing Li et al.

Summary: The study reveals that miR-19a/b and miR-20a are crucial regulators of wound inflammation, and their lack may contribute to sustained inflammation and impaired healing in chronic wounds. Combinatory treatment with miR-19b and miR-20a improved wound healing in a mouse model of type 2 diabetes.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

Tamil S. Anthonymuthu et al.

Summary: HpETE-PE is a cell death signal in ferroptosis, produced by the 15LOX/PEBP1 complex. Fer-1 does not directly affect 15LOX, but can effectively inhibit the production of HpETE-PE by the 15LOX/PEBP1 complex. This study resolves the long-standing Fer-1 anti-ferroptotic paradox.

REDOX BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Long non-coding RNAs: From disease code to drug role

Yuanyuan Chen et al.

Summary: Extensive studies have shown that long non-coding RNAs (lncRNAs) play crucial roles in physiological processes and are closely linked to various diseases. Using lncRNAs as biomarkers or intervention targets can provide new perspectives for disease diagnosis and treatment. Research is shifting towards utilizing lncRNAs as pharmacological targets, with a focus on preclinical research and clinical trial progress.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Cell Biology

LNCcation: lncRNA localization and function

Mary Catherine Bridges et al.

Summary: This review summarizes the current knowledge of subcellular localization of long noncoding RNAs (lncRNAs), factors controlling their localization, emerging themes, and discusses the implications of lncRNA localization on their function and cellular behavior, as well as opportunities for future research.

JOURNAL OF CELL BIOLOGY (2021)

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Article Cell Biology

Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

Cheng Chen et al.

Summary: This study revealed that the long non-coding RNA Meg3 mediated ferroptosis in rat brain microvascular endothelial cells (RBMVECs) upon injury induced by oxygen-glucose deprivation (OGD) and hyperglycemia by modulating the p53 signaling pathway.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

1,25(OH)2D3 Inhibited Ferroptosis in Zebrafish Liver Cells (ZFL) by Regulating Keap1-Nrf2-GPx4 and NF-κB-hepcidin Axis

Ke Cheng et al.

Summary: In a zebrafish liver cell model, preincubation with 1,25(OH)(2)D-3 significantly improved cell survival and inhibited ferroptosis by regulating the expression of a series of genes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy

Tingjuan Ni et al.

Summary: The study investigated the role of lncRNA-ZFAS1 in diabetic cardiomyopathy (DbCM) and found that ZFAS1 acts as a ceRNA to sponge miR-150-5p and downregulate CCND2 to promote cardiomyocyte ferroptosis and DbCM development. Inhibition of ZFAS1 could be a promising therapeutic target for the treatment and prevention of DbCM.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

LncRNA NEAT1 Promotes High Glucose-Induced Mesangial Cell Hypertrophy by Targeting miR-222-3p/CDKN1B Axis

Lin Liao et al.

Summary: This study describes a novel pathway in which lncRNA NEAT1 regulates mesangial cell hypertrophy through a ceRNA mechanism. NEAT1 forms dsRNA with miR-222-3p, releasing CDKN1B mRNA and leading to hypertrophy. Additionally, HG-activated STAT3 induces NEAT1 transcription by binding to its promoter, revealing an unexpected role of lncRNAs in gene regulation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biochemistry & Molecular Biology

Treatment-Induced Neuropathy in Diabetes (TIND)-Developing a Disease Model in Type 1 Diabetic Rats

Petra Baum et al.

Summary: This study aimed to investigate the hypothesis that a rapid decrease in HbA1c induced by insulin treatment may be the primary cause of TIND. The results showed that high-dose insulin treatment caused a mild acute neuropathy in BB/OKL diabetic rats.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis

Zhu-Qiu Jin

Summary: Cardiac fibrosis, a main characteristic of diabetic cardiomyopathy, is influenced by multiple signaling pathways, with TGF-beta/Smad2/3 pathway playing a central role. miRNAs, stable molecules involved in gene silencing, are dysregulated in the diabetic heart, promoting or inhibiting cardiac fibrosis by targeting various pathways in different cardiac cells. Detection of miRNAs in plasma or serum could potentially serve as biomarkers for diabetes mellitus or heart failure diagnosis, providing insight into the pathogenesis of cardiac fibrosis.

PHARMACOLOGICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

Jiucui Li et al.

Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Medicine, Research & Experimental

LncRNA Blnc1 mediates the permeability and inflammatory response of cerebral hemorrhage by regulating the PPAR-γ/SIRT6/FoxO3 pathway

Lijuan Xie et al.

Summary: Silencing Blnc1 alleviated nerve injury and inflammatory response caused by ICH through activating PPAR-gamma/SIRT6/FoxO3 pathway. Blnc1 levels were positively correlated with PPAR-gamma levels, and Blncl interference suppressed PPAR-y/SIRT6-mediated activation of FoxO3 signaling in ICH mice.

LIFE SCIENCES (2021)

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Article Cell Biology

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

Seonghun Kim et al.

Summary: The study evaluated the role of ferroptosis in diabetes-induced tubular injury. Results indicated that ferroptosis triggers kidney cell death by affecting glutathione concentration and lipid peroxidation, and the use of ferroptosis inhibitors can alleviate this process.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11

Hui Dong et al.

Summary: Nrf2 negatively regulates ferroptosis by modulating TERT and SLC7A11 levels, providing potential therapeutic targets for IIR-ALI.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

Ferrostatin-1 attenuates ferroptosis and protects the retina against light-induced retinal degeneration

Wenyi Tang et al.

Summary: The study revealed that light exposure induced pro-ferroptotic changes in photoreceptor cells, suggesting the involvement of ferroptosis in light-induced retinal degeneration. Treatment with ferrostatin-1 alleviated the effects of light-induced ferroptosis and protected the retina from damage, indicating its potential as a novel therapeutic target for preventing retinal degeneration.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

lncRNA MALAT1 promotes diabetic retinopathy by upregulating PDE6G via miR-378a-3p

Xiaoxia Li

Summary: The study revealed that the MALAT1/miR-378a-3p/PDE6G signaling axis inhibits apoptosis of RMECs under high glucose conditions, which may help delay the development of diabetic retinopathy.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Article Endocrinology & Metabolism

Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice

Shuiling Zhao et al.

Summary: The study found that Nrf2 regulates Sglt2 expression in a diabetes model, leading to effects on blood glucose levels and kidney injury.

DIABETES (2021)

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Article Pharmacology & Pharmacy

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Xiang Wang et al.

Acta Pharmaceutica Sinica B (2021)

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Article Multidisciplinary Sciences

Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p

Wenjing Xiao et al.

Summary: The study found that MIAT expression is elevated in diabetic patients, high-glucose induced cardiomyocytes, and diabetic mice, and plays a role in the occurrence of pyroptosis in DCM. Silencing MIAT can reduce the expression levels of CASP1 and pyroptosis-related factors, potentially serving as a treatment strategy for DCM.

ISCIENCE (2021)

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Review Endocrinology & Metabolism

Ferritinophagy and ferroptosis in the management of metabolic diseases

Amir Ajoolabady et al.

Summary: Ferroptosis is a type of regulated cell death associated with disturbed iron homeostasis and lipid peroxidation, playing an important role in human diseases. Ferritinophagy, through degradation of ferritin, contributes to the initiation of ferroptosis, showing potential as a therapeutic target in managing metabolic diseases.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Pharmacology & Pharmacy

lncRNA MALAT1 Promotes Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-2355-3p/IL6ST Axis

Haozi Huang et al.

Summary: The overexpression of MALAT1 in diabetic rats and HG-treated cells may exacerbate renal fibrosis and cell damage via the miR-2355-3p/IL6ST axis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Quantitative proteomic analysis of human peripheral nerves from subjects with type 2 diabetes

Erik Ising et al.

Summary: This study used quantitative mass spectrometry to analyze peripheral nerves from male tissue donors, identifying 2617 proteins. Differential protein expression between type 2 diabetes subjects and controls was explored using linear regression, and clustering analysis of the 500 most variable proteins was conducted.

DIABETIC MEDICINE (2021)

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Article Immunology

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-kappa B signal pathway

Nao Yan et al.

Summary: The study demonstrates the neuroprotective effect of DMF in improving cognitive deficits and reversing hippocampus neuronal damage and loss caused by CCH. DMF reduces inflammation, oxidative stress, and inhibits ferroptosis in hippocampal neurons, thus improving cognitive impairment. The upregulation of the NRF2/ARE signaling pathway and related gene expressions contribute to the neuroprotective role of DMF.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

Yin Yao et al.

Summary: Researchers found that T follicular helper (T-FH) cells are highly sensitive to ferroptosis, and this process is regulated by the activity of the selenoenzyme GPX4. Selenium supplementation can increase GPX4 expression, leading to an increase in T-FH cell numbers and antibody responses.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Daniel M. Kremer et al.

Summary: Cancer metabolism is rewired to support cell survival, with targeting metabolic dependencies following GOT1 inhibition leading to ferroptosis, an iron-dependent form of cell death. The study identifies a biochemical connection between GOT1, iron regulation, and ferroptosis in pancreatic cancer cells.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

Li Li et al.

Summary: The study reveals the important role of Tug1/PGC1α axis in the progression of diabetic nephropathy by influencing mitochondrial remodeling and altered metabolites. Furthermore, PGC1α is identified as a necessary factor for the renoprotective effect of Tug1.

CELL REPORTS (2021)

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Review Endocrinology & Metabolism

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

Wenxin Sha et al.

Summary: Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxide accumulation and inadequate GPX4. It is ubiquitous in physiological and pathological processes, playing a role in the pathogenesis of diabetes.

JOURNAL OF DIABETES RESEARCH (2021)

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Review Endocrinology & Metabolism

Emerging Role of Long Non-Coding RNAs in Diabetic Vascular Complications

Vinay Singh Tanwar et al.

Summary: Chronic metabolic disorders like obesity and diabetes are associated with accelerated vascular complications, and long non-coding RNAs play a crucial role in regulating gene expression in these diseases. Understanding the characteristics and mechanisms of lncRNAs can provide insights for the development of new therapeutic approaches to manage these disorders effectively.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus

Jie Wang et al.

Summary: This review summarizes recent advances in targeting NRF2-related epigenetic modifications for the treatment of cardiac and vascular complications associated with diabetes mellitus. It also discusses potential agonists that could regulate NRF2-associated epigenetic mechanisms.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Medicine, General & Internal

Long noncoding RNA MIAT inhibits the progression of diabetic nephropathy and the activation of NF-κB pathway in high glucose-treated renal tubular epithelial cells by the miR-182-5p/GPRC5A axis

Qianlan Dong et al.

Summary: This study demonstrates that MIAT acts as an inhibitory factor in the pathogenesis of DN by regulating the miR-182-5p/GPRC5A axis, thereby preventing cell damage induced by high glucose and inactivating the NF-kappa B pathway.

OPEN MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance

Chao Chen et al.

Summary: The study reveals that the overload of atRAL leads to photoreceptor degeneration through activating ferroptosis. Inhibiting Fe2+ or lipid peroxidation can protect photoreceptor cells from ferroptosis induced by atRAL. Ferroptosis may be an important pathway of photoreceptor cell death in dry AMD and STGD1, and should be explored as a novel target for protection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy

Shuangwen Li et al.

Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Engineering, Environmental

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

Sen Wei et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

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Article Engineering, Biomedical

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

Yu-Jing He et al.

BIOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Fulvio Ursini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Cell Biology

Circular RNA in renal diseases

Juan Jin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

Dandan Han et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

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Review Urology & Nephrology

Genetics of diabetes mellitus and diabetes complications

Joanne B. Cole et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Cell Biology

LncRNA ANRIL Silencing Alleviates High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis via Upregulation of MME in Podocytes

Ruiyu Cai et al.

INFLAMMATION (2020)

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Review Cell Biology

Protective role of NRF2 in macrovascular complications of diabetes

Junduo Wu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes

Xinzhi Li et al.

MOLECULAR THERAPY (2020)

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Article Endocrinology & Metabolism

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Huimei Zang et al.

DIABETES (2020)

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Article Cell Biology

Loss of lncRNA MIAT ameliorates proliferation and fibrosis of diabetic nephropathy through reducing E2F3 expression

Ting-Ting Ji et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

Zhuanzhuan Qiang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Pharmacology & Pharmacy

The Application of Ferroptosis in Diseases

Yangmin Qiu et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Cell & Tissue Engineering

TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling

Yang Li et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Endocrinology & Metabolism

DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway

Yue He et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

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Article Cell Biology

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Hongdong Ma et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Biochemistry & Molecular Biology

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan et al.

CELL CHEMICAL BIOLOGY (2020)

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Article Neurosciences

The Role of Iron and Nerve Inflammation in Diabetes Mellitus Type 2-Induced Peripheral Neuropathy

Sabine Paeschke et al.

NEUROSCIENCE (2019)

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Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

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Letter Cardiac & Cardiovascular Systems

LncRNA NEAT1 aggravates diabetic myocardial ischemia-reperfusion injury through regulating PINK1 by targeting miR-27b

Zhihua Ruan et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

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Review Cell Biology

Non-coding RNA involvement in the pathogenesis of diabetic cardiomyopathy

Wei Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

lncRNA MALAT1 mediated high glucose-induced HK-2 cell epithelial-to-mesenchymal transition and injury

Jun Zhang et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

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Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Cell Biology

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Eunhee Park et al.

CELL DEATH & DISEASE (2019)

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Article Cell Biology

LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-kappa B/NLRP3 inflammasome pathway

Mengru Ma et al.

CELL PROLIFERATION (2019)

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Article Endocrinology & Metabolism

lncRNA H19 prevents endothelial-mesenchymal transition in diabetic retinopathy

Anu A. Thomas et al.

DIABETOLOGIA (2019)

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Article Cell Biology

LncRNA NEAT1 promotes extracellular matrix accumulation and epithelial-to-mesenchymal transition by targeting miR-27b-3p and ZEB1 in diabetic nephropathy

Xiaowei Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Plant Sciences

Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses

Li Li et al.

PHYTOMEDICINE (2019)

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Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

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Article Medicine, Research & Experimental

LncRNA DCRF regulates cardiomyocyte autophagy by targeting miR-551b-5p in diabetic cardiomyopathy

Yu Feng et al.

THERANOSTICS (2019)

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Review Medicine, General & Internal

NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases

Abhishek Suwal et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

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Article Biochemistry & Molecular Biology

A shared comparison of diabetes mellitus and neurodegenerative disorders

Mahmoud Morsi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Heike Miess et al.

ONCOGENE (2018)

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Review Biochemistry & Molecular Biology

Long Noncoding RNAs in Diabetes and Diabetic Complications

Amy Leung et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy

Si-yang Yu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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