Journal
FRONTIERS IN PHYSIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.1004275
Keywords
chronic obstructive pulmonary disease; autophagy; oxidative stress; interplay; molecular mechanism
Categories
Funding
- Key Laboratory of Intelligent Computing in Medical Image, Northeastern University, Ministry of Education [17-134-8-00]
- Department of Science and Technology of Liaoning Province [2018225006]
- Shenyang Science and Technology Plan Project [21-173-9-43]
- 345 Talent Project of Shengjing Hospital, and Science and technology projects in Liaoning Province [2020JH2/10300125]
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Autophagy is a crucial process for cell survival, development, and tissue balance. It protects cells against oxidative stress and injury. Dysregulated autophagy caused by factors like smoking and aging can lead to increased production of reactive oxygen species (ROS) and oxidative damage. ROS activates autophagy, which helps cells adapt and reduce damage by eliminating damaged molecules and organelles. Understanding the regulation of oxidative stress and autophagy is important in chronic obstructive pulmonary disease (COPD) research.
Autophagy is a highly conserved process that is indispensable for cell survival, embryonic development, and tissue homeostasis. Activation of autophagy protects cells against oxidative stress and is a major adaptive response to injury. When autophagy is dysregulated by factors such as smoking, environmental insults and aging, it can lead to enhanced formation of aggressors and production of reactive oxygen species (ROS), resulting in oxidative stress and oxidative damage to cells. ROS activates autophagy, which in turn promotes cell adaptation and reduces oxidative damage by degrading and circulating damaged macromolecules and dysfunctional cell organelles. The cellular response triggered by oxidative stress includes changes in signaling pathways that ultimately regulate autophagy. Chronic obstructive pulmonary disease (COPD) is the most common lung disease among the elderly worldwide, with a high mortality rate. As an induced response to oxidative stress, autophagy plays an important role in the pathogenesis of COPD. This review discusses the regulation of oxidative stress and autophagy in COPD, and aims to provide new avenues for future research on target-specific treatments for COPD.
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