Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.963179
Keywords
traditional Chinese medicine(TCM); cerebral ischemia; ferroptosis; apoptosis; autophagy
Categories
Funding
- National Natural Science Foundation of China [81704064]
- Natural Science Foundation of Hunan Provincial [2022JJ30436]
- Outstanding Youth Program of Scientific Research of Hunan Provincial Department of Education [20B434]
- Natural Science Foundation of Changsha City [kq2202259]
- Scientific Research Project of Hunan Provincial Administration of Traditional Chinese Medicine [202177]
- Chinese medicine in Hunan Province [3]
- 2021 Hunan University of Traditional Chinese Medicine Graduate Innovation Project [2021CX53]
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This article reviews the latest research findings on the treatment of cerebral ischemia with traditional Chinese medicine focused on ferroptosis as a target, and discusses the correlation with other cell death pathways.
Traditional Chinese medicine (TCM) has attracted a great deal of attention in the treatment of cerebral ischemia is credited with the remarkable neuroprotective effects. However, the imperfect functional mechanism of TCM is a major obstacle to their application. Many studies have been conducted to illustrate the pathophysiology of post-ischemic cerebral ischemia by elucidating the neuronal cell death pathway. Meanwhile, a new type of cell death, ferroptosis, is gradually being recognized in various diseases and is becoming a new pathway of therapeutic intervention strategy to solve many health problems. Especially since ferroptosis has been found to be closely involved into the pathogenesis of cerebral ischemia, it has been considered as a key target in the treatment of cerebral ischemia. Therefore, this paper reviews the latest research findings about the treatment of cerebral ischemia with TCM focused on ferroptosis as a target. Also, in order to explores the possibility of a new approach to treat cerebral ischemia with TCM, we discusses the correlation between ferroptosis and other cell death pathways such as apoptosis and autophagy, which would provide references for the following researches.
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