Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1013992
Keywords
Lonicerae Japonicae Flos; botany; ethnopharmacology; phytochemistry; pharmacology; toxicology
Categories
Funding
- National Natural Science Foundation of China [81703684, 81973604]
- Heilongiiang Touyan Innovation Team Program
- National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of National Administration of TCM [75]
- Seventh Batch of National Old Traditional Chinese Medicine Experts Academic Experience Inheritance Program [76]
- Central Finance to Support the Development of Local Universities
- scientific research project of Heilongjiang Provincial Health Commission [20211313050171]
- Second affiliated hospital of heilongjiang university of chinese medicine [ZHY2022-170]
- Scientific research Project of Heilongjiang Administration of Traditional Chinese Medicine
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Lonicerae Japonicae Flos has been used for over 1,500 years as a tea and medicine with functions of clearing heat and detoxification. It has various pharmacological actions, including anti-inflammatory, antiviral, and antibacterial effects. Further research is needed for the comprehensive evaluation of its quality and understanding of multi-target network pharmacology.
Lonicerae Japonicae Flos has been used as a tea and medicine for more than 1,500 years. It has the functions of clearing heat, detoxification, and is often used to treat carbuncle, furuncle, throat arthralgia, erysipelas, heat-toxic blood dysentery, febrile fever. This paper summarizes the botany, ethnopharmacology, chemical composition and pharmacological action of Lonicerae Japonicae Flos from 1986 to 2022, and looks forward to the future research direction of Lonicerae Japonicae Flos. At present, the components isolated from Lonicerae Japonicae Flos include essential oils, organic acids, flavonoids, iridoids, saponins and other compounds. It has the effects of anti-inflammation, anti-virus, anti-bacteria, anti-oxidation, anti-tumor, protect liver and galltesticles, hypotensive, hypolipidemic, anti-thrombosis, anti-allergy, immune regulation and so on. It is often used in clinical treatment of diarrhea, hematochezia, febrile disease, exogenous wind-heat, and cold, swelling and toxin of carbuncle, sore throat and so on. The comprehensive evaluation of the quality of Lonicerae Japonicae Flos and the understanding of multi-target network pharmacology also need to be studied. As a kind of health food with high value, LJF is worthy of further promotion and development.
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