Podoplanin: Its roles and functions in neurological diseases and brain cancers

Podoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in different cell types including choroid plexus epithelial cells, glial cells, as well as periphery infiltrated immune cells during brain development and neurological disorders. As a transmembrane protein, podoplanin interacts with other molecules in the same or neighboring cells. In the past, a lot of studies reported a pleiotropic role of podoplanin in the modulation of thrombosis, inflammation, lymphangiogenesis, angiogenesis, immune surveillance, epithelial mesenchymal transition, as well as extracellular matrix remodeling in periphery, which have been well summarized and discussed. Recently, mounting evidence demonstrates the distribution and function of this molecule in brain development and neurological disorders. In this review, we summarize the research progresses in understanding the roles and mechanisms of podoplanin in the development and disorders of the nervous system. The challenges of podoplanin-targeted approaches for disease prognosis and preventions are also discussed.

Automated summary

Podoplanin is a protein involved in various physiological and pathological processes in the brain. It is upregulated in different cell types and interacts with other molecules. Past studies have summarized its pleiotropic roles in the periphery, while recent research focuses on its distribution and function in the brain. This review summarizes the roles and mechanisms of Podoplanin in the development and disorders of the nervous system and discusses the challenges of using Podoplanin as a target for disease prognosis and prevention.