Neuropharmacological efficacy of metformin for stroke in rodents: A meta-analysis of preclinical trials

Article Pharmacology & Pharmacy

Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5′-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice

Lei Jin et al.

Summary: Metformin exerts its neuroprotective effects by inhibiting neuroinflammation, modulating the production of proinflammatory factors associated with NLRP3, and suppressing microglial activation.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway

Ke Liu et al.

Summary: This research investigated the effect and mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury. The results showed that metformin protected against cerebral I/R injury by upregulating BDNF expression and activating the AMPK/CREB pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Neurosciences

Metformin attenuates early brain injury after subarachnoid hemorrhage in rats via AMPK-dependent mitophagy

Yongzhi Zhang et al.

Summary: Metformin attenuated early brain injury after subarachnoid hemorrhage through AMPK-dependent signaling, promoting mitophagy and improving mitochondrial morphology.

EXPERIMENTAL NEUROLOGY (2022)

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Article Neurosciences

Effect of metformin on outcome after acute ischemic stroke in patients with type 2 diabetes mellitus

C. J. B. A. Kersten et al.

Summary: This study aimed to assess the association between metformin use and functional outcome in patients with type 2 diabetes mellitus and acute ischemic stroke. The results showed that pre-stroke metformin use was associated with a favorable outcome after acute ischemic stroke in patients with type 2 diabetes mellitus.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2022)

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Article Clinical Neurology

Metformin Ameliorates Neuronal Necroptosis after Intracerebral Hemor-rhage by Activating AMPK

Chenhan Lin et al.

Summary: The study found that metformin can effectively inhibit neuronal necroptosis after ICH by activating the AMPK related pathway, resulting in significant improvements in neurological function scores and reduction in brain edema.

CURRENT NEUROVASCULAR RESEARCH (2021)

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Review Cell Biology

Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis

Liuwang Zeng et al.

Summary: Melatonin shows promising effects in improving outcomes in animal models of intracerebral hemorrhage, with positive impacts on neurobehavioral outcomes and cerebral edema reduction. However, the interpretation of results should consider the limitations in experimental design and methodological quality of the studies included in the meta-analysis.

AGING-US (2021)

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Article Chemistry, Medicinal

Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats

Gintare Zemgulyte et al.

Summary: The study demonstrates that post-stroke treatment with metformin exhibits anti-inflammatory and neuroprotective effects in a model of permanent middle cerebral artery occlusion, improving neurological deficits, reducing infarct size, and preventing neuronal loss in the ischemic cortex.

PHARMACEUTICALS (2021)

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Article Medicine, General & Internal

Clinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China

Hong-Qiu Gu et al.

Summary: The study evaluated the clinical characteristics, management, and outcomes of stroke or TIA patients in China. Results showed that management measures and clinical outcomes varied by cerebrovascular event type, with substantial improvements observed over time. The study suggests support for the use of evidence-based practices is still needed to enhance care quality for stroke and TIA patients in China.

JAMA NETWORK OPEN (2021)

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Review Oncology

Impact of Metformin on Cancer Biomarkers in Non-Diabetic Cancer Patients: A Systematic Review and Meta-Analysis of Clinical Trials

Tahereh Farkhondeh et al.

Summary: Metformin therapy showed no significant changes in metabolic biomarkers in most clinical trials with breast and endometrial cancer patients, but it was found to decrease Ki-67 levels in patients with endometrial cancer. Due to high heterogeneity and bias in the trials, the effectiveness of metformin for breast and endometrial cancer patients could not be confirmed or rejected based on the current findings.

CURRENT ONCOLOGY (2021)

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Article Clinical Neurology