Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1002915
Keywords
ceramides; gangliosides; S1P; lipid rafts; treg; Th17; bioactive lipids
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG)
- [GR2011/7-1]
- [SFB1039]
Ask authors/readers for more resources
The concept of proper resolution of inflammation has gained attention in recent years. This review focuses on the role of T cells and sphingolipids in the resolution of inflammation, providing insights into potential therapeutic approaches.
The concept of proper resolution of inflammation rather than counteracting it, gained a lot of attention in the past few years. Re-assembly of tissue and cell homeostasis as well as establishment of adaptive immunity after inflammatory processes are the key events of resolution. Neutrophiles and macrophages are well described as promotors of resolution, but the role of T cells is poorly reviewed. It is also broadly known that sphingolipids and their imbalance influence membrane fluidity and cell signalling pathways resulting in inflammation associated diseases like inflammatory bowel disease (IBD), atherosclerosis or diabetes. In this review we highlight the role of sphingolipids in T cells in the context of resolution of inflammation to create an insight into new possible therapeutical approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available