Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.922029
Keywords
traditional Chinese medicine; ginseng; ginsenosides; gastrointestinal tumors; immunotherapy
Categories
Funding
- National Natural Science Foundation of China
- Shanghai Pujiang talent program
- [82173106]
- [82130115]
- [20PJ1413000]
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This article summarizes the research on the use of ginsenosides in immunotherapy of gastrointestinal tumors and discusses their potential future applications.
In the past decade, immunotherapy has been the most promising treatment for gastrointestinal tumors. But the low response rate and drug resistance remain major concerns. It is therefore imperative to develop adjuvant therapies to increase the effectiveness of immunotherapy and prevent drug resistance. Ginseng has been used in Traditional Chinese medicine as a natural immune booster for thousands of years. The active components of ginseng, ginsenosides, have played an essential role in tumor treatment for decades and are candidates for anti-tumor adjuvant therapy. They are hypothesized to cooperate with immunotherapy drugs to improve the curative effect and reduce tumor resistance and adverse reactions. This review summarizes the research into the use of ginsenosides in immunotherapy of gastrointestinal tumors and discusses potential future applications.
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