Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.953903
Keywords
cAMP; sperm motility; capacitation; fertility; adcy10; birth control
Categories
Funding
- NIH [P50 HD100549, R01 HD088571, R01 AG061290, F31 HD105363]
- Male Contraceptive Initiative
- USAID
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This article discusses the 10 isoforms of adenylyl cyclase that produce the second messenger cyclic AMP in humans, including nine G protein-coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and one bicarbonate-regulated soluble adenylyl cyclase (sAC; ADCY10). It highlights the unique druggability of sAC and outlines approaches to target sAC for novel forms of male and female contraception.
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.
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