4.7 Review

Metabolic reprogramming: A novel therapeutic target in diabetic kidney disease

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria

Irena Audzeyenka et al.

Summary: This review summarizes the current knowledge about podocyte mitochondrial dynamics in diabetic nephropathy, with a focus on bioenergetic pathways. It highlights key studies in this field and potential opportunities to enhance or protect podocyte mitochondrial function in the treatment of diabetic nephropathy.

ENDOCRINOLOGY (2022)

Review Biochemistry & Molecular Biology

Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes

Anju Singh et al.

Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.

MOLECULES (2022)

Article Endocrinology & Metabolism

Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

Chen Chen et al.

Summary: Trigonelline reduces high glucose-induced cell injury in human mesangial cells by regulating the Wnt/beta-catenin signaling pathway.

DIABETOLOGY & METABOLIC SYNDROME (2022)

Article Medicine, Research & Experimental

Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy

Jialin Fu et al.

Summary: This study reveals that overexpression of PKM2 in podocytes can protect against diabetic nephropathy by preserving glomerular mitochondrial function through the activation of paracrine factors such as VEGF. The findings suggest that PKM2 may be a potential therapeutic target for the treatment of diabetic nephropathy.

JCI INSIGHT (2022)

Review Medicine, General & Internal

The Glomerulus According to the Mesangium

Kerstin Ebefors et al.

Summary: The glomerulus consists of endothelial cells, basement membrane, podocytes and mesangial cells, which maintain high permselectivity, prevent large proteins from passing through, and filter small solutes and water. The mesangial cells play an important role in the onset and progression of glomerular disease.

FRONTIERS IN MEDICINE (2022)

Article Cell Biology

IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis

Chengcheng Song et al.

Summary: Renal inflammation is a critical characteristic of diabetic kidney disease (DKD), but effective treatments are limited. This study found that insulin-like growth factor-binding protein 5 (IGFBP5) is significantly increased in the kidneys of diabetic mice. Elimination of IGFBP5 alleviated kidney inflammation in DKD mice. Mechanistically, IGFBP5 increased glycolysis in endothelial cells through the activation of the transcription factor EGR1 and enhanced expression of PFKFB3, which in turn enhanced renal inflammation.

CELL DEATH & DISEASE (2022)

Review Cardiac & Cardiovascular Systems

Emerging Roles of SIRT3 in Cardiac Metabolism

Krishnega Murugasamy et al.

Summary: The heart, as a highly metabolically active organ, primarily uses fatty acids as an energy source. SIRT3, a deacetylase, plays a crucial role in regulating cardiac metabolism. Increasing SIRT3 levels or activity can alleviate cardiac pathologies, as SIRT3 targets mitochondrial proteins involved in energy metabolism. This review emphasizes the importance of SIRT3 as a master regulator of cardiac metabolism and discusses potential therapeutic strategies for improving cardiac health.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Integrative & Complementary Medicine

Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) improves renal mesangial cell damage in diabetic nephropathy by inhibiting the inflammatory response of infiltrated macrophages

Xiao Lin et al.

Summary: The study found that in diabetic nephropathy, A&P effectively alleviates renal pathological damage and inflammation by inhibiting the Mincle/Card9/NF kappa B signaling pathway.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

Article Pharmacology & Pharmacy

VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses

Yilan Shen et al.

Summary: The combination of VEGF-B and IL-22 may help reduce the progression of DN by regulating glycolipid metabolism to decrease inflammation and ROS accumulation.

ACTA PHARMACEUTICA SINICA B (2021)

Article Endocrinology & Metabolism

The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation

Haijie Liu et al.

Summary: Activation of PKM2 can prevent kidney fibrosis by suppressing the EMT program and aberrant glycolysis, offering a potential target for mitigating fibrosis in diabetic kidneys.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Multidisciplinary Sciences

Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu

Alberto Valdes et al.

Summary: The study revealed that the combined exposure of high glucose and hypoxia significantly altered multiple metabolic pathways in HK-2 cells, including carbohydrate, pentose phosphate, arginine, and proline metabolism. Other affected metabolites were found in purine and lipid metabolism, as well as in protecting against osmotic stress and preventing the activation of the beta-oxidation pathway. Overall, the effects observed are consistent with previous in vivo studies.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1α/miR-210/ISCU/FeS Pathway

Wei-long Xu et al.

Summary: The study demonstrates that quercetin can mitigate glucose fluctuation-induced renal injury by suppressing aerobic glycolysis via the HIE-1 alpha/miR-210/ISCU/FeS pathway in a cell model. This protective effect is dose-dependent and provides new insights into the mechanism of glucose fluctuation-induced renal injury and the potential therapeutic effects of quercetin.

FRONTIERS IN MEDICINE (2021)

Article Oncology

IL-22-mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

Wei Chen et al.

Summary: The study shows that interleukin-22 (IL-22) can attenuate kidney injury by reprogramming the metabolism of renal tubular epithelial cells (TECs) and alleviating mitochondrial reactive oxygen species (ROS) accumulation. IL-22 improves kidney function in cisplatin-induced kidney damage and diabetic nephropathy (DN) animal models by inducing AMPK/AKT signaling and PFBFK3 activities.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia

Azadeh Harzandi et al.

Summary: Metabolic disruption in the kidney leads to fibrosis in patients with CKD, contributing to abnormal lipid profiles. Studying mouse and in vitro models revealed dysfunctional fatty acid metabolism associated with CKD progression.

ISCIENCE (2021)

Review Endocrinology & Metabolism

Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities

Ping Na Zhang et al.

Summary: Research suggests that mitochondrial dysfunction is a contributing factor in the progression of renal diseases, including diabetic nephropathy. Pharmacological regulation of mitochondrial networking shows promise as a therapeutic strategy. Nontraditional therapies such as herbal medicine and lifestyle interventions also hold potential value in treating diabetic nephropathy.

JOURNAL OF DIABETES RESEARCH (2021)

Review Cell Biology

Mitochondria in Diabetic Kidney Disease

Amna Ayesha Ahmad et al.

Summary: Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA, with a multifactorial pathogenesis involving activation of multiple signaling pathways that lead to various pathological changes, mainly driven by alterations in mitochondrial bioenergetics. Understanding the role of bioenergetics in the progression of DKD may offer novel therapeutic approaches to delay progression to ESRD.

CELLS (2021)

Review Medicine, General & Internal

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Lu Wen et al.

Summary: The kidneys play a crucial role in glucose homeostasis and abnormal glucose metabolism is associated with kidney diseases such as acute kidney injury. This review discusses the regulation of glucose homeostasis in kidneys and the impact of glucose metabolism on different types of AKI. Further research on glucose metabolism in kidney injury and repair could lead to the discovery of new therapeutic targets for kidney diseases.

FRONTIERS IN MEDICINE (2021)

Review Medicine, General & Internal

Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD

Roberto Pagliarini et al.

Summary: Metabolic reprogramming characterized by the utilization of aerobic glycolysis and reduction in oxidative phosphorylation is a key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The role of polycystin proteins in this metabolic shift remains unclear, despite the identification of numerous signaling pathways. Integration of computational data analysis is crucial for identifying metabolic reprogramming in ADPKD.

FRONTIERS IN MEDICINE (2021)

Review Medicine, General & Internal

Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease

Hua Wang et al.

Summary: Research suggests that lipotoxicity plays a significant role in renal injury during the progression of diabetic nephropathy, primarily leading to glomerular dysfunction.

FRONTIERS IN MEDICINE (2021)

Review Medicine, General & Internal

Metabolic Reprogramming and Renal Fibrosis

Xiaoyu Zhu et al.

Summary: Chronic kidney disease is associated with renal fibrosis, which is influenced by metabolic abnormalities. Normal energy metabolism is crucial for maintaining kidney structure and function. Future challenges include identifying and developing new drugs that disrupt metabolic reprogramming and fibrosis progression.

FRONTIERS IN MEDICINE (2021)

Review Urology & Nephrology

Phenotypic diversity and metabolic specialization of renal endothelial cells

Sebastien J. Dumas et al.

Summary: Renal endothelial cells exhibit phenotypic and molecular heterogeneity in response to different microenvironments, supporting kidney functions and potentially serving as targets for therapeutic strategies. Understanding the diversity and specialization of kidney endothelial cells could offer new approaches for treating kidney diseases and promoting kidney regeneration.

NATURE REVIEWS NEPHROLOGY (2021)

Review Biochemistry & Molecular Biology

The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives

Shulin Li et al.

Summary: Chronic kidney disease affects a significant portion of the global population and is characterized by renal fibrosis. Understanding the cellular and molecular mechanisms underlying renal fibrosis is crucial for developing new therapies. Vascular endothelium plays a crucial role in maintaining normal vascular function, inhibiting inflammation, and smooth muscle cell proliferation.

CELL AND BIOSCIENCE (2021)

Article Multidisciplinary Sciences

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys

Swayam Prakash Sriyastava et al.

Summary: Endothelial SIRT3 regulates defective metabolism and fibrogenic pathways in diabetic kidneys, with its loss exacerbating fibrosis levels. SIRT3 deficiency in endothelial cells stimulates mesenchymal transformations in renal tubular epithelial cells.

ISCIENCE (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis

Diana Salnikova et al.

Summary: Altered mitochondrial function plays a crucial role in the initiation and progression of atherosclerosis, leading to changes in cellular metabolism, respiration, and increased production of reactive oxygen species. Mitochondrial dysfunction is associated with vascular disease and chronic inflammation, and targeted approaches to reduce oxidative stress and inflammation show promise in atherosclerosis treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Sirt3 promotes the autophagy of HK-2 human proximal tubular epithelial cells via the inhibition of Notch-1/Hes-1 signaling

Ying Wang et al.

Summary: The study revealed that Sirt3 promotes autophagy in HK-2 cells, at least partly, through the downregulation of Notch-1/Hes-1.

MOLECULAR MEDICINE REPORTS (2021)

Review Cell Biology

The Loss of Mitochondrial Quality Control in Diabetic Kidney Disease

Wenni Dai et al.

Summary: Diabetic kidney disease is a major complication of diabetes mellitus, with a complex pathogenesis involving inflammation, autophagy impairment, and oxidative stress. The loss of mitochondrial quality control plays a critical role in the progression of DKD.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Letter Biochemistry & Molecular Biology

Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation

Lei Fang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Medicine, General & Internal

Renal Lipid Metabolism and Lipotoxicity in Diabetes

Laongdao Thongnak et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Jinhua Li et al.

EMBO REPORTS (2020)

Article Endocrinology & Metabolism

Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy

Le Li et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2020)

Review Pediatrics

Metabolic requirements of the nephron

Kasey Cargill et al.

PEDIATRIC NEPHROLOGY (2020)

Article Pharmacology & Pharmacy

Metabolic reprogramming byN-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease

Swayam Prakash Srivastava et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion

Paola Venditti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes

Monica Locatelli et al.

SCIENTIFIC REPORTS (2020)

Article Cell Biology

TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy

Hanxu Zeng et al.

INFLAMMATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Advances in characterization of SIRT3 deacetylation targets in mitochondrial function

Shuhan Wang et al.

BIOCHIMIE (2020)

Review Medicine, Research & Experimental

Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

Jin Zhang et al.

THERANOSTICS (2020)

Article Endocrinology & Metabolism

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy

Daniel Gordin et al.

DIABETES CARE (2019)

Article Medicine, General & Internal

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

V. Perkovic et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Pharmacology & Pharmacy

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

Leyuan Chen et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

Review Biochemistry & Molecular Biology

Pyruvate kinase M2: A simple molecule with complex functions

Mohammed Alquraishi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Multidisciplinary Sciences

Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

Ryoichi Bessho et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats

Yuri Miura et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Review Biochemistry & Molecular Biology

Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria

Luke W. Thomas et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Medicine, Research & Experimental

SIRT3 deficiency exacerbates p53/Parkin-mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts

Yan Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Review Biochemistry & Molecular Biology

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

Jan F. C. Glatz et al.

JOURNAL OF LIPID RESEARCH (2018)

Review Genetics & Heredity

Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism

Weier Qi et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2018)

Review Physiology

ENDOTHELIAL CELL METABOLISM

Guy Eelen et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Endocrinology & Metabolism

Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy

Silvia Maestroni et al.

ACTA DIABETOLOGICA (2018)

Article Cardiac & Cardiovascular Systems

Shear stress augments mitochondrial ATP generation that triggers ATP release and Ca2+ signaling in vascular endothelial cells

Kimiko Yamamoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Cell Biology

SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis

Swayam Prakash Srivastava et al.

CELL DEATH & DISEASE (2018)

Article Biochemistry & Molecular Biology

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

Toshiyuki Imasawa et al.

FASEB JOURNAL (2017)

Article Biochemistry & Molecular Biology

Enhanced Aerobic Glycolysis by S-Nitrosoglutathione via HIF-1 Associated GLUT1/Aldolase A Axis in Human Endothelial Cells

Jieping Yan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Biology

Modeling glucose metabolism and lactate production in the kidney

Ying Chen et al.

MATHEMATICAL BIOSCIENCES (2017)

Review Urology & Nephrology

Mitochondrial energetics in the kidney

Pallavi Bhargava et al.

NATURE REVIEWS NEPHROLOGY (2017)

Review Urology & Nephrology

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

Xiaochun Yang et al.

NATURE REVIEWS NEPHROLOGY (2017)

Article Medicine, General & Internal

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Endocrinology & Metabolism

Macro- and microvascular endothelial dysfunction in diabetes

Yi Shi et al.

JOURNAL OF DIABETES (2017)

Review Urology & Nephrology

Crosstalk of Hyperglycemia and Dyslipidemia in Diabetic Kidney Disease

Wen Su et al.

KIDNEY DISEASES (2017)

Review Biochemistry & Molecular Biology

Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3

Ariela Benigni et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Biochemistry & Molecular Biology

Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells

Xiaocui Jiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Biology

Modeling Glucose Metabolism in the Kidney

Ying Chen et al.

BULLETIN OF MATHEMATICAL BIOLOGY (2016)

Article Endocrinology & Metabolism

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

Bijaya K. Nayak et al.

DIABETES (2016)

Article Multidisciplinary Sciences

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Marco Sciacovelli et al.

NATURE (2016)

Article Multidisciplinary Sciences

Oncometabolite D-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

Anja Karlstaedt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Physiology

Systemic and renal lipids in kidney disease development and progression

Patricia Wahl et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Article Medicine, Research & Experimental

Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications

Kelli M. Sas et al.

JCI INSIGHT (2016)

Review Cell Biology

The role of STAT3 in autophagy

Liangkun You et al.

AUTOPHAGY (2015)

Article Cell Biology

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Xudong Fu et al.

CELL METABOLISM (2015)

Article Cell Biology

Pyruvate kinase M2 at a glance

Weiwei Yang et al.

JOURNAL OF CELL SCIENCE (2015)

Article Immunology

Contribution of metabolic reprogramming to macrophage plasticity and function

Karim C. EL Kasmi et al.

SEMINARS IN IMMUNOLOGY (2015)

Review Physiology

Glomerular endothelial cell injury and cross talk in diabetic kidney disease

Jia Fu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)

Review Nutrition & Dietetics

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

Marta Yanina Pepino et al.

ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)

Review Pharmacology & Pharmacy

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

G. C. Higgins et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Endocrinology & Metabolism

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

Katherine R. Tuttle et al.

DIABETES CARE (2014)

Article Biochemistry & Molecular Biology

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

Michal Herman-Edelstein et al.

JOURNAL OF LIPID RESEARCH (2014)

Editorial Material Urology & Nephrology

Phenotypic characteristics of diabetic kidney involvement

Roland C. Blantz

KIDNEY INTERNATIONAL (2014)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Multidisciplinary Sciences

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism

Hung-Jung Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Endocrinology & Metabolism

Assessment of early diabetic renal changes with hyperpolarized [1-13C]pyruvate

Christoffer Laustsen et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2013)

Review Geriatrics & Gerontology

SIRT3 regulation of mitochondrial oxidative stress

Alexandra S. Bause et al.

EXPERIMENTAL GERONTOLOGY (2013)

Article Biochemistry & Molecular Biology

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

Anne H. H. Tseng et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Podocyte energy metabolism and glomerular diseases

Toshiyuki Imasawa et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Physiology

Macrophages directly mediate diabetic renal injury

Hanning You et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Pharmacology & Pharmacy

Sirtuins: Common Targets in Aging and in Neurodegeneration

Rita Machado de Oliveira et al.

CURRENT DRUG TARGETS (2012)

Review Urology & Nephrology

The glomerular endothelium: new insights on function and structure

Borje Haraldsson et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI

Wen-Jie Yin et al.

EUROPEAN JOURNAL OF RADIOLOGY (2012)

Article Biochemistry & Molecular Biology

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences (2012)

Article Biochemistry & Molecular Biology

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

Wei Yu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

Xueliang Gao et al.

MOLECULAR CELL (2012)

Review Biochemical Research Methods

Oxygen versus Reactive Oxygen in the Regulation of HIF-1 alpha: The Balance Tips

Thilo Hagen

BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)

Article Biochemistry & Molecular Biology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Weibo Luo et al.

Article Cell Biology

NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway

Li Zhuo et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)

Review Urology & Nephrology

Glucose handling by the kidney

Amanda Mather et al.

KIDNEY INTERNATIONAL (2011)

Article Multidisciplinary Sciences

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

Lydia W. S. Finley et al.

PLOS ONE (2011)

Article Cell Biology

Bioenergetic characterization of mouse podocytes

Yoshifusa Abe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Article Biochemistry & Molecular Biology

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

Huseyin Cimen et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong et al.

Review Biochemistry & Molecular Biology

Liver fatty acid-binding protein and obesity

Barbara P. Atshaves et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2010)

Article Biochemical Research Methods

Monitoring phosphorylation of the pyruvate dehydrogenase complex

Matthew J. Rardin et al.

ANALYTICAL BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

Lei Jin et al.

PROTEIN SCIENCE (2009)

Article Biochemistry & Molecular Biology

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi et al.

SCIENCE SIGNALING (2009)

Review Nutrition & Dietetics

The emerging functions and mechanisms of mammalian fatty acid-binding proteins

Judith Storch et al.

ANNUAL REVIEW OF NUTRITION (2008)

Article Biochemistry & Molecular Biology

Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells

Malou Friederich et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2008)

Article Urology & Nephrology

Adaptation to hypoxia in the diabetic rat kidney

C. Rosenberger et al.

KIDNEY INTERNATIONAL (2008)

Article Multidisciplinary Sciences

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Bong-Hyun Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Medicine, Research & Experimental

Glucose enhances mesangial cell apoptosis

Tarnjit Khera et al.

LABORATORY INVESTIGATION (2006)

Article Biochemistry & Molecular Biology

Mitochondrial ROS-induced ROS release: An update and review

Dmitry B. Zorov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)

Review Endocrinology & Metabolism

Hexosamines, insulin resistance, and the complications of diabetes: current status

MG Buse

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Review Biochemistry & Molecular Biology

A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria

Nathan R. Brady et al.

ANTIOXIDANTS & REDOX SIGNALING (2006)

Article Transplantation

Mechanical stress and glucose concentration modulate glucose transport in cultured rat podocytes

B Lewko et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)

Article Transplantation

Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis

FY Chow et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2004)

Article Endocrinology & Metabolism

Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension

F Palm et al.

DIABETOLOGIA (2003)

Article Multidisciplinary Sciences

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

P Onyango et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

Article Endocrinology & Metabolism

Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells

T Asano et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2000)