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Drug reprofiling history and potential therapies against Parkinson's disease

Journal

FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1028356

Keywords

Parkinson; 's disease; drug discovery; neurodegeneration

Funding

  1. Institutional Fund Projects [IFPDP-10-22]
  2. Ministry of Education and Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia
  3. Poltava State Medical University [0121U108235, 0119U102848]

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Drug repurposing is an attractive approach for pharmaceutical development, as it allows the use of existing drugs to treat different diseases. In the case of Parkinson's disease, a neurodegenerative condition, drug repurposing strategies can be applied effectively.
Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing old drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the way toward utilizing existing medications in treating diseases other than the purposes they were initially designed for. Faced with scientific and economic challenges, the prospect of discovering new medication indications is enticing to the pharmaceutical sector. Medication repurposing can be used at various stages of drug development, although it has shown to be most promising when the drug has previously been tested for safety. We describe strategies of drug repurposing for Parkinson's disease, which is a neurodegenerative condition that primarily affects dopaminergic neurons in the substantia nigra. We also discuss the obstacles faced by the repurposing community and suggest new approaches to solve these challenges so that medicine repurposing can reach its full potential.

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