Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.998944
Keywords
atherosclerosis; inflammation; natural drugs; interleukin; TCM
Categories
Funding
- National Nature Science Foundation of China
- Shandong Provincial Natural Science Foundation
- China Postdoctoral Science Foundation
- Taishan Scholar Post Construction Fund
- [81974566]
- [82004277]
- [ZR2020QH309]
- [2021M690099]
- [ts201712042]
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This article reviews the potential targets for inflammation against atherosclerosis, discusses the underlying mechanisms of natural drugs for treating atherosclerosis, particularly highlights the current research dilemma, and ultimately provides perspectives in this field.
Atherosclerosis (AS) is the chronic gradual degradation of arteries in combination with inflammation. Currently, the main research focus has been on interactions between inflammatory cells, inflammatory mediators, and immune mechanisms, while some studies have reported natural drugs were exerting a critical role against AS, whereas the usage of natural drugs was always limited by various factors such as poor penetration across biological barriers, low bioavailability, and unclear mechanisms. Herein, we reviewed the potential targets for inflammation against AS, discussed the underlying mechanisms of natural drugs for AS, particularly highlighted the dilemma of current research, and finally, offered perspectives in this field.
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