Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.829677
Keywords
rheumatoid arthritis; resveratrol; SIRT1; NF-kappa B; drug delivery system
Categories
Funding
- Natural Science Foundation of Anhui Province
- innovation training program for college students in Anhui Province [2108085MH264]
- early contact scientific research training program for undergraduates in Anhui Medical University [s202110366032]
- [2021-zqky-101]
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This review explores the therapeutic effects of resveratrol on rheumatoid arthritis (RA) by activating the SIRT1 pathway. It also discusses the crosstalk between SIRT1 and NF-kappa B pathways, and their role in the development of RA.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by symmetrical polyarthritis as its main clinical manifestation. Uncontrolled RA eventually leads to joint deformities and loss of function. Currently, the pathogenesis of RA remains under discussion, and RA treatment is still at the bottleneck stage. Resveratrol has long been regarded as a potential antioxidant drug for RA treatment. Currently, resveratrol is considered to exert therapeutic effects on RA by activating silent information regulator 1 (SIRT1) and its downstream pathways. There is notable crosstalk between the SIRT1 and NF-kappa B pathways, and these pathways, which play an essential role in the development of RA, are unexpectedly linked to the influence of resveratrol. Based on recent studies of almost all the pathways that resveratrol can affect, this review summarizes a regulatory chain of core components that cover multiple tracks. We also list the effects of resveratrol on immune cells and other subtle controls, which can help clinicians understand the known mechanism of resveratrol and better treat patients with RA.
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