Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.1021207
Keywords
neuropsychiatric disorders; cerebral ischemia; mental illness; neurologic disorders; BDNF; Gadd45b
Categories
Funding
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province, China
- Academic Promotion Programme of Shandong First Medical University
- [81601018]
- [ZR2021MH043]
- [2019QL013]
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This study provides an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, in various neurological diseases.
Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critical role in epigenetic DNA demethylation, neuroplasticity, and neuroprotection, according to accumulating evidence. This article provided an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, focusing on major psychosis, depression, autism, stroke, seizure, dementia, Parkinson's disease, and autoimmune diseases of the nervous system.
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