Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 30, Issue 21, Pages 2585-2589Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2016.1256994
Keywords
RDS; single-nucleotide polymorphism; association; SP-C; surfactant protein C; SP-C codon 186 polymorphism; SPC N186S; Iran
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Funding
- Tehran University of Medical Sciences [91-03-91-19315]
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Background: Respiratory distress syndrome (RDS) is a severe pulmonary disease that mainly affects preterm neonates. Surfactant-protein genes' polymorphisms have been mostly evaluated as the candidate contributors in genetics of RDS. However, the results are diverse in different populations. We aimed at investigating the association of rs1124 with RDS development. Method: Three hundred and thirty five preterm neonates were enrolled in a multicenter case-control study. Respiratory distress (RD) was scored according to Downes' scoring system. Genotyping was performed by PCR-RFLP method. Result: One hundred and sixty six neonates showed RDS and 169 did not. Gestational age (GA) was significantly lower in RDS group compared to the controls. In female preterm newborns, AA genotype was found more frequently in RDS group. In RDS group, AA genotype was also associated with milder RD irrespective of gender. In neonates who were born 28-34 weeks, RD appeared to be more severe in the RDS group and males. Conclusions: This is the first report of association of SFTPC rs1124 polymorphism with RDS development in Iranian newborns. The current study suggests that GA528-weeks is the most important factor in predisposition to RDS. AA genotype is also, a predisposing factor for the development of RDS in female preterm infants.
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