Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 29, Issue 22, Pages 3583-3589Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2016.1139570
Keywords
Amniotic fluid; bisphenol A; maternal plasma; preterm birth
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Funding
- Dept. of OB-GYN, The University of Texas Medical Branch at Galveston, Galveston, TX
- National Institutes of Health [1R01ES023116-01]
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Objective: The objective of this study is to determine if BPA exposure, as measured by maternal plasma (MP) and amniotic fluid (AF) BPA concentrations is associated with an increased risk of spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM).Methods: In this nested case-control study, MP samples from women in term labor (n=30), preterm labor that ended with preterm delivery (n=25), or who had pPROM (n=30) and amniotic fluid samples from term labor (n=45), preterm labor (n=60), and pPROM (n=35) were assayed for BPA by enzyme immunoassay.Results: BPA was detectible in 100% of MP and AF samples. Women with MP BPA concentrations in the fourth quartile were at increased risk of PTB (cOR=4.12, 95% CI=1.32-12.87; aOR=4.78, 95% CI=1.14-20) but not pPROM. High (fourth quartile) AF BPA values also tended to increase the risk of pPROM (cOR=2.47, 95% CI=0.96-6.37) but results were not statistically significant.Conclusions: Increased BPA concentration is associated with an increased risk for PTB or pPROM depending on the maternal-fetal compartment(s) affected. High MP plasma BPA concentrations are associated with PTB with intact membranes but high AF BPA concentrations may weakly be associated with pPROM.
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