Journal
MICROMACHINES
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/mi13111833
Keywords
cancer cells; dielectrophoresis; electrical impedance spectroscopy
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Funding
- Technical University of Iasi (TUIASI), Romania
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This study proposes a feasible approach for the rapid, sensitive, and label-free identification of cancerous cells based on dielectrophoretic manipulation and electrical characterization. The method demonstrates the ability to electrically differentiate cancer cells from healthy cells based on impedance spectra.
This study proposes a feasible approach for the rapid, sensitive, and label-free identification of cancerous cells based on dielectrophoretic (DEP) manipulation and electrical characterization. In this method, the concentration of target cells at the level of customized microelectrodes via DEP is first determined, followed by an electrical impedance evaluation. The study demonstrates the capacity of the methodology to electrically differentiate HT-29 cancer cells from healthy blood cells based on their impedance spectra. Within a higher frequency domain, the electrical impedance of trapped cancer cells was significantly lower compared with the normal ones. In order to evaluate the functionality and reproducibility of the proposed method, the influence of the DEP and EIS (electrical impedance spectroscopy) operating voltages on the electrical characterization of trapped HT-29 cells was analyzed.
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