Journal
JOURNAL OF WOUND CARE
Volume 31, Issue 10, Pages 882-885Publisher
MA HEALTHCARE LTD
DOI: 10.12968/jowc.2022.31.10.882
Keywords
diabetes; diabetic foot ulcer; hard-to-heal wounds; hyperglycaemia; impaired wound healing; wound; wound care; wound dressing; wound healing
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Impaired wound healing in patients with diabetes is influenced by various factors, including hyperglycemia and inflammation. Optimizing glycemic control is the primary intervention to prevent further dysfunction and comorbid disease progression.
Impaired wound healing for patients with diabetes is due to a constellation of structural, biochemical, cellular and microbial factors. Hyperglycaemia and its associated inflammation contribute to immune dysfunction, vascular damage, neuropathy, cellular senescence, impaired transition beyond the inflammatory stage, microbiome disruptions, failed extracellular matrix formation, growth factor and cytokine imbalance, limited re-epithelialisation, and alterations in fibroblast migration and proliferation. Optimising glycaemic control remains the primary intervention to prevent continual dysfunction and comorbid disease progression.
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