Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-022-01589-1
Keywords
NanoFe; Sepsis; Heart failure
Funding
- National Natural Science Foundation of China [81871607, 82070422, 21674085, 81660210, 81600306]
- National Postdoctoral Program for Innovative Talent [BX20190277]
- Innovation Capability Strong Foundation Plan of Xi'an City (Medical Research Project) [21YXYJ0037]
- Natural Science Foundation of Shaanxi Province [2020JM-386, 2018JM3042]
- Key Research and Development Program of Shaanxi [2020ZDLSF04-03]
- Major Research Projects of Xi'an Science and Technology Plan [201805104YX12SF38(2)]
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This study found that nanoFe has a protective effect on septic myocardial injury by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.
Background: Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown. Results: NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis. Conclusions: The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury.
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