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New anti-cancer explorations based on metal ions

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Copper induces cell death by targeting lipoylated TCA cycle proteins

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Iron imbalance in cancer: Intersection of deficiency and overload

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The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma

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Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

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Novel heterobimetallic Ir(III)-Re(I) complexes: design, synthesis and antitumor mechanism investigation

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A new class of nickel(II) oxyquinoline-bipyridine complexes as potent anticancer agents induces apoptosis and autophagy in A549/DDP tumor cells through mitophagy pathways

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Targeting ferroptosis as a vulnerability in cancer

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Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

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Design of a novel Pt(II) complex to reverse cisplatin-induced resistance in lung cancer via a multi-mechanism

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Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

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Article Nanoscience & Nanotechnology

Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T-1-T-2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery

Ling Zhu et al.

Summary: A novel magnetic nanocatalyst was developed for MRI-guided chemo- and ferroptosis synergistic cancer therapies, releasing abundant Fe(II) ions to induce oxidative stress and promote ferroptosis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

Dharambir Kashyap et al.

Summary: The application of natural product-based nanoformulations in the treatment of various human diseases, such as cancer, is a growing field. Nanotechnology in cancer therapeutics has overcome the limitations of conventional drug delivery systems, with promising results in targeting tumor cells and reducing side effects. The integration of phytotherapy and nanotechnology in clinical settings may lead to better pharmacological responses and improved clinical outcomes for patients.

SEMINARS IN CANCER BIOLOGY (2021)

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Functional CT Contrast Nanoagents for the Tumor Microenvironment

Xianfu Meng et al.

Summary: Understanding the tumor microenvironment is crucial for effective tumor treatment, and using functional CT contrast nanoagents can help accurately diagnose TME and guide personalized treatment.

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Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

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ADVANCED HEALTHCARE MATERIALS (2021)

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Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

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Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

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Article Chemistry, Multidisciplinary

Nitric Oxide Modulating Calcium Store for Ca2+-Initiated Cancer Therapy

Xu Chu et al.

Summary: This research developed a new nanodonor that can release nitric oxide and berbamine under near-infrared light stimulation, achieving cancer therapy by regulating intracellular Ca2+. This work provides insight into regulating endogenous ions for cell killing.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biochemistry & Molecular Biology

The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity

Jia Song et al.

Summary: This study identifies OTDU1 as a crucial regulator in iron transportation in cancer, promoting the immune response against tumors. OTUD1 depletion limits tumor-reactive T-cell accumulation and exacerbates cancer progression. The data highlights the significance of OTUD1-IREB2-TFRC signaling axis in host antitumor immunity.

EMBO REPORTS (2021)

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Review Biochemistry & Molecular Biology

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Zdenek Kejik et al.

Summary: Flavonoids, common plant natural products, can suppress ROS-related damage through chelation of transition metal ions, with iron being the most significant. Their interaction with Fe(II) and Fe(III) ions can significantly affect their biological properties. Special biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been discussed in this review.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nutrition & Dietetics

Effects of storage practices on long-chain polyunsaturated fatty acids and lipid peroxidation of preterm formula milk

I. Nessel et al.

Summary: The study found that storage conditions of preterm formula milk do not support in utero accretion rates for LCPUFAs. Although it is clear that powdered formula is more susceptible to lipid peroxidation during refrigeration, specific recommendations still require further research.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease

Darius J. R. Lane et al.

Summary: Ferroptosis is a cell death mechanism dependent on iron and lipid peroxidation, with potential implications in various neurodegenerative diseases. The main cellular protector against ferroptosis is glutathione peroxidase 4 (GPX4). The NRF2 signaling pathway plays a key role in regulating ferroptosis.

MOLECULAR MECHANISMS OF NEURODEGENERATION (2021)

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Ferroptosis: mechanisms, biology and role in disease

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Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Novel multifunctional theranostic nanoagents based on Ho3+ for CT/MRI dual-modality imaging-guided photothermal therapy

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Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

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Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

Rohini Gupta et al.

Summary: 8-Hydroxyquinoline is an important heterocyclic scaffold in organic and analytical chemistry, used for detecting metal ions and anions due to its chromophore properties. Recently, synthetic modification of 8-hydroxyquinoline has garnered attention for developing potent drug molecules for the treatment of diseases like cancer, HIV, and neurodegenerative disorders. The metal chelation properties of 8-hydroxyquinoline and its derivatives also make them potential drug candidates for various diseases.

BIOORGANIC CHEMISTRY (2021)

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Article Computer Science, Artificial Intelligence

A diagnostic prediction framework on auxiliary medical system for breast cancer in developing countries

Genghua Yu et al.

Summary: An intelligent system is used to filter and extract hidden information from patient data to aid accurate diagnostic decisions, while utilizing images and blood tests to provide intelligent treatment plans for doctors. This paper proposes a framework for predicting the diagnosis of patient disease by combining images and labeling parameters, showing promising results in testing.

KNOWLEDGE-BASED SYSTEMS (2021)

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Article Biochemistry & Molecular Biology

Comparative Study of Antioxidant and Pro-Oxidant Properties of Homoleptic and Heteroleptic Copper Complexes with Amino Acids, Dipeptides and 1,10-Phenanthroline: The Quest for Antitumor Compounds

Nicolas Veiga et al.

Summary: The study investigated a series of copper complexes with amino acids and dipeptides, as well as their performance in antitumor mechanisms. Results indicate that Cu-amino acid complexes are strong producers of reactive oxygen species, while Cu-dipeptide-phen complexes are good SOD mimics.

MOLECULES (2021)

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Article Chemistry, Multidisciplinary

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

Binbin Ding et al.

Summary: This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy, which can release ions to induce intracellular osmotic imbalance and trigger cell death mechanisms. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity, inhibiting tumor growth and pulmonary metastasis.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun et al.

Summary: Metalloimmunotherapy utilizes metal ions to amplify the anti-tumour immune response promoted by STING agonists, forming nanoparticles that effectively deliver STING agonists and achieve remarkable therapeutic efficacy in multiple tumour models. This work highlights the great potential of coordination nanomedicine for metalloimmunotherapy.

NATURE NANOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy

Xianchuang Liu et al.

Summary: The study demonstrated the use of a nanodevice as an effective strategy for inducing HCC ferroptosis, with promising results both in vitro and in vivo.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Oncology

Intraoperative MRI for Brain Tumors

Cara Marie Rogers et al.

Summary: This article reviews the history of intraoperative MRI, its clinical application in neurosurgery, and future directions. Intraoperative MRI has been shown to improve extent of tumor resection and prevent injury to important structures during tumor surgery.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Materials Science, Biomaterials

Disulfiram-loaded functionalized magnetic nanoparticles combined with copper and sodium nitroprusside in breast cancer cells

Kubra Solak et al.

Summary: Disulfiram, a reactive species generator, can induce cancer cell death in breast cancer but it degrades easily in blood. This study prepared a drug carrier system based on magnetic mesoporous silica nanoparticles to support selective accumulation of DSF in tumor cells. The system showed high drug-loading capacity and achieved cancer-selective accumulation through modifications with folic acid linked polyethyleneimine. The cytotoxicity of the system on breast cancer cells was higher than on non-tumorigenic cells due to enhanced uptake by cancer cells.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Pan Zheng et al.

Summary: This study developed an acid-sensitive nanoparticle ((CaCUR)-Ca-PEG) that induces mitochondrial Ca2+ overload and acts as an ICD inducer in improved cancer therapy. Combination with ultrasound (US) enhances the ICD effect, showing promising therapeutic and diagnostic properties.

NANO LETTERS (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Neurosciences

Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

Natali L. Chanaday et al.

Summary: The study found that acute ER Ca2+ depletion increases presynaptic Ca2+ levels and glutamate release, while chronic ER stress leads to syt7-dependent potentiation of spontaneous glutamate release. Inhibition of SOCE or syt7-driven fusion during ER stress can partially restore basal neurotransmission.

NEURON (2021)

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Article Multidisciplinary Sciences

Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa

Jon B. Patteson et al.

Summary: The study reveals that Pseudomonas aeruginosa is able to synthesize a small-molecule copper complex, fluopsin C, in response to elevated copper concentrations, which serves as a broad-spectrum antibiotic. The pathway involves five enzymes and suggests a common role for fluopsin C in the copper stress response among various bacteria, highlighting its potential as an antibiotic against other microbes.

SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

Lulu Zhou et al.

Summary: The study developed a novel nanocomplex HMTBF to induce ferroptosis/apoptosis synergism in TNBC, demonstrating superior in vivo antitumor efficacy in a mouse model, suggesting potential for combinatorial TNBC therapy.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Photoactivated Self-Disassembly of Multifunctional DNA Nanoflower Enables Amplified Autophagy Suppression for Low-Dose Photodynamic Therapy

Jinjin Shi et al.

Summary: The multifunctional DNA nanoflower developed in this study can target tumor cells specifically, enhance autophagy suppression, and potentially serve as a safe low-dose photodynamic therapy strategy for cancer treatment.

SMALL (2021)

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Article Multidisciplinary Sciences

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Weier Bao et al.

Summary: A novel nanoagent combining upconversion nanoparticles and metal-organic frameworks was developed for near-infrared light-triggered synergistic oxidative stress and calcium overload, resulting in multilevel damage to mitochondria and showing therapeutic potency in tumor cells.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Conferring Ti-Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Shuang Liang et al.

Summary: Researchers have developed a novel sonosensitizer D-MOF(Ti) for enhanced sonodynamic therapy, which exhibits superior ROS yield and Fenton-like activity under ultrasound irradiation. The synergistic outcomes of sonodynamic and chemodynamic therapy have been achieved using ultrasound as the excitation source.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Xuan Tan et al.

Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Biophysics

Iron overload in the HCT patient: a review

Pavan Tenneti et al.

Summary: Iron overload is common in hematologic malignancies and hemoglobinopathies, primarily due to red cell transfusion burden. The impact of pretransplant iron overload on hematopoietic cell transplant outcomes remains contentious, with studies showing mixed results. Treatment options include phlebotomy, chelation, or a combination of both, with potential future options involving bone marrow maturation agents or targeted chelation around the time of highest iron overload risk.

BONE MARROW TRANSPLANTATION (2021)

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Article Biochemical Research Methods

Rapid Screening and Estimation of Binding Constants for Interactions of Fe3+ with Two Metalloproteins, Apotransferrin and Transferrin, Using Affinity Mode of Capillary Electrophoresis

Mohammed Al Bratty et al.

Summary: This study investigated the interaction behavior of Fe3+ with transferrin and apotransferrin using affinity capillary electrophoresis and found different binding patterns at various metal ion concentrations. Transferrin exhibited significant interactions at higher concentrations, while apotransferrin showed strong binding interactions at relatively higher Fe3+ concentrations.

JOURNAL OF SPECTROSCOPY (2021)

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Article Cell Biology

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

Yi-Ping Wang et al.

Summary: Mitochondria have an independent genome and protein synthesis machinery for their generation. This study reveals that the Krebs cycle intermediate fumarate connects metabolism to mitobiogenesis by binding to malic enzyme 2 (ME2). Manipulation of mitobiogenesis through the fumarate-ME2 axis could be a potential target for both normal and malignant cells.

CELL METABOLISM (2021)

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Article Pharmacology & Pharmacy

Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

Peng Zhang et al.

Summary: PEI-modified Bi2Se3 nanodots demonstrate excellent photothermal therapy efficacy and CT imaging performance in vitro and in vivo, serving as a safe and superior nanotheranostic platform for cancer treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Environmental Sciences

Microwave-assisted green synthesis of fluorescent carbon quantum dots from Mexican Mint extract for Fe3+ detection and bio-imaging applications

Natarajan Architha et al.

Summary: Biomass-derived carbon quantum dots synthesized from Mexican Mint leaves via microwave-assisted reflux method exhibited strong fluorescence properties and high sensitivity to Fe3+ ions, allowing for the construction of logic gates and effective application in cell imaging.

ENVIRONMENTAL RESEARCH (2021)

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Article Environmental Sciences

Elucidation of DNA binding interaction of new Cu(II)/Zn(II) complexes derived from Schiff base and L-tryptophan amino acid: a multispectroscopic and molecular docking approach

Mohd Afzal et al.

Summary: The synthesis, structural elucidation, and DNA interaction of newly synthesized Cu(II) and Zn(II) complexes were described. Both complexes were found to avidly bind to DNA through surface and groove binding modes, with different intrinsic binding constants. Various experiments confirmed the electrostatic and groove binding modes of the complexes, paving the way for the development of DNA-targeting Cu(II)/Zn(II) metal complexes as chemotherapeutic agents.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

Qing Cheng et al.

Summary: This study discusses a new method for producing mammalian selenoproteins in E. coli, including GPX1, GPX2, and GPX4. Through various experiments and analyses, it reveals the characteristics of selenoproteins and a unique phenomenon of codon skipping in recombinant proteins.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Ferric iron reductases and their contribution to unicellular ferrous iron uptake

Timothy J. Cain et al.

Summary: Iron is essential for life and its acquisition by unicellular pathogens through siderophores is crucial for virulence. Ferric reductases play a key role in reducing Fe3+ to Fe2+ for uptake, but remain poorly understood, highlighting the important connection between Fe3+ reduction and Fe2+ transport.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

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Review Endocrinology & Metabolism

Ferritinophagy and ferroptosis in the management of metabolic diseases

Amir Ajoolabady et al.

Summary: Ferroptosis is a type of regulated cell death associated with disturbed iron homeostasis and lipid peroxidation, playing an important role in human diseases. Ferritinophagy, through degradation of ferritin, contributes to the initiation of ferroptosis, showing potential as a therapeutic target in managing metabolic diseases.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Oncology

Calcification in thymomas can predict invasiveness to surrounding organs

Mitsuteru Yoshida et al.

Summary: Calcification in thymomas is associated with the invasiveness of tumors to surrounding organs and tissues, and may predict the stage and high-risk histology of thymomas. This could help in deciding therapeutic methods and surgical approaches based on the calcification status observed from CT findings.

THORACIC CANCER (2021)

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Article Chemistry, Multidisciplinary

Construction of Smart Nanotheranostic Platform Bi-Ag@PVP: Multimodal CT/PA Imaging-Guided PDT/PTT for Cancer Therapy

Zonglang Zhou et al.

Summary: Novel high-efficiency nanotheranostic agents with multimodal imaging guidance have been synthesized for precise cancer treatment. These agents can combine CT/PA imaging and PDT/PTT therapy, showing enhanced photothermal effects and efficient tumor ablation through the induction of reactive oxygen species (ROS). Additionally, they exhibit potential antibacterial properties, which could minimize the risk of infection during cancer therapy and offer broad clinical application prospects.

ACS OMEGA (2021)

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Article Nanoscience & Nanotechnology

H2O2 Self-Supplying and GSH-Depleting Nanoplatform for Chemodynamic Therapy Synergetic Photothermal/Chemotherapy

Zhimei Xiao et al.

Summary: This study proposed an intelligent nanoplatform that induces the depletion of GSH and self-supply of H2O2 in tumor cells to enhance the efficacy of chemodynamic therapy (CDT). Through various mechanisms, the integration of chemotherapy, photothermal therapy, and CDT was realized.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Editorial Material Biochemistry & Molecular Biology

A Picture Is Worth a Thousand Words: The Power of Neuroimaging

Peter J. H. Scott

ACS CHEMICAL NEUROSCIENCE (2021)

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Article Pharmacology & Pharmacy

Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline

Junya Kakegawa et al.

Summary: The study identified GPX4 as a binding protein of CNP through thermal proteome profiling, showing that CNP treatment induced lipid ROS accumulation and autophagy similarly to the inhibition of GPX4. These findings suggest that GPX4 is the target protein of CNP involved in autophagy induction, and demonstrate the utility of TPP in determining the mechanisms of natural compounds.

MOLECULAR PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

A Ferrocene-Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

Le-Le Zhou et al.

Summary: A nanodrug, RSL3@COF-Fc (2b), based on covalent organic framework (COF) has been fabricated to enhance cellular damage induced by CDT through promoting Fenton-like reactions and inhibiting GPX4 irreversibly. This approach synergistically results in massive lipid peroxide accumulation, subsequent cell damage, and ultimately ferroptosis, not being limited by intracellular glutathione, providing new insights for developing COF-based nanomedicine.

SMALL (2021)

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Article Cell Biology

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

Jiashuo Zheng et al.

Summary: Sorafenib does not induce ferroptosis and only a subset of tumor cell lines experience ferroptosis in response to system x(c)(-) inhibitors. These findings suggest that different tumor cells exhibit varying responses to ferroptosis.

CELL DEATH & DISEASE (2021)

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Article Engineering, Biomedical

pH-Sensitive Molecular-Switch-Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy-Cascade Ferroptosis and Tumor Immune Activation

Tiantian Zuo et al.

Summary: The combination therapy utilizing ferritinophagy-cascade ferroptosis and tumor immunity activation shows promise for cancer treatment. The use of active tumor targeting nanoparticles to release drugs for inhibiting tumor growth and metastasis is an effective strategy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Necroptosis: A Novel Pathway in Neuroinflammation

Ziyu Yu et al.

Summary: Necroptosis, a form of cell death triggered by the rupture of dead cells, plays a significant role in the pathogenesis of neuroinflammatory diseases. Inhibitors of necroptosis have shown promise in improving pathological changes and clinical symptoms associated with neurological disorders. Targeting necroptotic factors may offer a potential therapeutic strategy for neuroinflammatory diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

A Promising Future of Ferroptosis in Tumor Therapy

Hui Wang et al.

Summary: Ferroptosis, as a form of cell death associated with iron and lipid peroxidation, has attracted extensive attention, with its underlying mechanisms and roles in various tumors being studied. The potential of combined treatment of anti-tumor drugs and radiotherapy holds promise as a new strategy for anti-tumor treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Modulation of Intracellular Copper Levels as the Mechanism of Action of Anticancer Copper Complexes: Clinical Relevance

Maria Babak et al.

Summary: Copper plays a crucial role in cellular growth and development and its imbalance can lead to toxicity. This review explores the mechanisms of intracellular copper balance interference in tumor development and progression, and discusses the potential of using copper-depleting and copper-overloading conditions for improved patient outcomes. Additionally, the advantages of pre-formed copper complexes in comparison to in situ formed complexes are highlighted.

BIOMEDICINES (2021)

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Article Chemistry, Analytical

Cancer photothermal therapy based on near infrared fluorescent CdSeTe/ZnS quantum dots

Jin Wang et al.

Summary: This paper investigates the application of CdTeSe/ZnS core-shell quantum dots (QDs) in cancer treatment. The QDs were prepared by aqueous synthesis and showed great potential in biomedical imaging and biological ablation therapy. The study provides a new research direction and method for cancer treatment.

ANALYTICAL METHODS (2021)

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Article Materials Science, Biomaterials

Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy

Min Liu et al.

Summary: The study developed a nanoplatform for specific chemodynamic/metal-ion therapy, which could release silver at the tumor site and generate highly toxic hydroxyl radicals through the degradation of external MOFs triggered by Cu2+-reduced glutathione. The combined treatment of CDT with metal-ion therapy showed excellent inhibition of tumor cell growth.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

Cancer therapeutic strategies based on metal ions

Yang Liu et al.

Summary: Metal ions play a crucial role in various physiological processes and can be utilized to effectively inhibit cancer cell growth, serving as a promising therapeutic approach with low likelihood of drug resistance.

CHEMICAL SCIENCE (2021)

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Review Materials Science, Biomaterials

Ferroptosis in cancer therapeutics: a materials chemistry perspective

Qun Guan et al.

Summary: Ferroptosis, a regulated form of cell death caused by lipid peroxidation, has been extensively studied since 2012. Recent research has shown a close relationship between ferroptosis and materials chemistry, particularly nanobiotechnology, and highlighted its potential as an efficient antitumor strategy, especially for apoptosis-resistant tumors.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy

Ping Ji et al.

Summary: The tumor cell membrane-camouflaged therapeutic system, embedding apyrase and glucose oxidase into nanoparticles, was shown to disrupt tumor cell energy supply by depleting ATP and glucose, leading to efficient tumor cell death.

CHEMICAL COMMUNICATIONS (2021)

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Article Materials Science, Biomaterials

Delivery of a system xc- inhibitor by a redox-responsive levodopa prodrug nanoassembly for combination ferrotherapy

Huhu Xin et al.

Summary: The study developed a self-assembled prodrug nanosystem targeting system x(c)(-) to enhance the therapeutic efficacy of cancer ferrotherapy. By inhibiting ferroptosis resistance and generating ROS in the tumor microenvironment, the nanoassembly induced ferroptosis. The prodrug nanosystem remained stable in physiological conditions but released active Fe2+ and SSZ in the tumor and intracellular reductive microenvironment to improve therapeutic outcomes.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Materials Science, Biomaterials

Recent progress on nanomedicine-induced ferroptosis for cancer therapy

Hajra Zafar et al.

Summary: Ferroptosis, a form of non-apoptotic cell death, shows potential in eliminating aggressive malignancies resistant to traditional therapies. The combination of nanomedicine and ferroptosis has shown efficacy in treating various types of cancer.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Yuxuan Xiong et al.

Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Biodegradable FeWOx nanoparticles for CT/MR imaging-guided synergistic photothermal, photodynamic, and chemodynamic therapy

Yaru Cheng et al.

Summary: In this study, simple and biodegradable FeWOx ternary oxide nanoparticles were synthesized and surface-modified to possess both MRI/CT imaging capabilities and synergistic photothermal therapy/photodynamic therapy/chemodynamic therapy. The NPs showed excellent anticancer efficiency and precise imaging guidance in tumor microenvironment, making them a promising and versatile nanotheranostic platform.

NANOSCALE (2021)

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Review Materials Science, Biomaterials

State-of-the-art advances of copper-based nanostructures in the enhancement of chemodynamic therapy

Ya-Nan Hao et al.

Summary: Chemodynamic therapy (CDT) is a novel strategy for treating tumors by inducing tumor cell death through the generation of reactive oxygen species (ROS). Copper-based nanostructures have received significant attention for their use in CDT, in conjunction with other therapies such as photothermal therapy, photodynamic therapy, and sonodynamic therapy for synergistic treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Biochemistry & Molecular Biology

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc-

Liyuan Wang et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Review Chemistry, Medicinal

Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer

Mei Liu et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Article Biochemistry & Molecular Biology

A hydrogen peroxide -activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells

Xia-Zhen Bao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Materials Science, Biomaterials

AgBiS2 nanoparticles with synergistic photodynamic and bioimaging properties for enhanced malignant tumor phototherapy

Jing Cheng et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Facile Preparation of MnO2 Quantum Dots with Enhanced Fluorescence via Microenvironment Engineering with the Assistance of Some Reductive Biomolecules

Zhangyan Ma et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Copper-Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification

Wencheng Wu et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells

S. Krishan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Article Engineering, Biomedical

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

Yu-Jing He et al.

BIOMATERIALS (2020)

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Review Pharmacology & Pharmacy

Theranostic application of nanoemulsions in chemotherapy

Bapi Gorain et al.

DRUG DISCOVERY TODAY (2020)

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Editorial Material Multidisciplinary Sciences

Sending copper where it is needed most

Svetlana Lutsenko

SCIENCE (2020)

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Article Multidisciplinary Sciences

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

Liam M. Guthrie et al.

SCIENCE (2020)

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Article Nanoscience & Nanotechnology

CuS-NiS2 nanomaterials for MRI guided phototherapy of gastric carcinoma via triggering mitochondria-mediated apoptosis and MLKL/CAPG-mediated necroptosis

Jian Chen et al.

NANOTOXICOLOGY (2020)

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Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Tumor-Targeted Cascade Nanoreactor Based on Metal-Organic Frameworks for Synergistic Ferroptosis-Starvation Anticancer Therapy

Xiuyan Wan et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy

Xiangyu Lu et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Analytical

In vivo tracking cystine/glutamate antiporter-mediated cysteine/cystine pool under ferroptosis

Zhen Li et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Engineering, Environmental

Bicompatible porous Co3O4 nanoplates with intrinsic tumor metastasis inhibition for multimodal imaging and DNA damage-mediated tumor synergetic photothermal/photodynamic therapy

Miaomiao Yuan et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Medicinal

Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer

Subha Bakthavatsalam et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

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Review Biochemistry & Molecular Biology

Copper Coordination Compounds as Biologically Active Agents

Olga Krasnovskaya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Analytical

Determination of Diethyldithiocarbamate in the Solid Phase of a Fibrous Cation Exchanger in the Cu-Form Using Diffuse Reflectance Spectroscopy

V. P. Dedkova et al.

JOURNAL OF ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

GSH-Depleted Nanozymes with Hyperthermia-Enhanced Dual Enzyme-Mimic Activities for Tumor Nanocatalytic Therapy

Shuming Dong et al.

ADVANCED MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

Katarzyna Galczynska et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

A Cellular Mechanism to Detect and Alleviate Reductive Stress

Andrew G. Manford et al.

CELL (2020)

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Article Chemistry, Multidisciplinary

An Aqueous Route Synthesis of Transition-Metal-Ions-Doped Quantum Dots by Bimetallic Cluster Building Blocks

Hui Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

Jiashuo Zheng et al.

CELL METABOLISM (2020)

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Review Chemistry, Multidisciplinary

Connecting the Dots: From Free Radical Lipid Autoxidation to Cell Pathology and Disease

Morgan K. Foret et al.

CHEMICAL REVIEWS (2020)

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Article Chemistry, Inorganic & Nuclear

Copper(II) Binding to PBT2 Differs from That of Other 8-Hydroxyquinoline Chelators: Implications for the Treatment of Neurodegenerative Protein Misfolding Diseases

Kelly L. Summers et al.

INORGANIC CHEMISTRY (2020)

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Review Optics

Recent advances on inorganic lanthanide-doped NIR-II fluorescence nanoprobes for bioapplication

Zhihua Li et al.

JOURNAL OF LUMINESCENCE (2020)

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Article Chemistry, Multidisciplinary

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

Yang Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Review Chemistry, Multidisciplinary

Metal-organic frameworks-based nanozymes for combined cancer therapy

Shuai-shuai Ding et al.

NANO TODAY (2020)

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Article Biochemistry & Molecular Biology

PBT2 acts through a different mechanism of action than other 8-hydroxyquinolines: an X-ray fluorescence imaging study

Kelly L. Summers et al.

METALLOMICS (2020)

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Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Combination of DN604 with gemcitabine led to cell apoptosis and cell motility inhibition via p38 MAPK signaling pathway in NSCLC

Xinyi Wang et al.

BIOORGANIC CHEMISTRY (2020)

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Review Engineering, Environmental

Microfluidic synthesis control technology and its application in drug delivery, bioimaging, biosensing, environmental analysis and cell analysis

Chia-Te Kung et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Oncology

Turning Cold into Hot: Firing up the Tumor Microenvironment

Qianqian Duan et al.

TRENDS IN CANCER (2020)

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Review Chemistry, Inorganic & Nuclear

Biomedical applications of copper ionophores

Valentina Oliveri

COORDINATION CHEMISTRY REVIEWS (2020)

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Article Materials Science, Biomaterials

A one-pot synthesis of multifunctional Bi2S3 nanoparticles and the construction of core-shell Bi2S3@Ce6-CeO2 nanocomposites for NIR-triggered phototherapy

Lingwan Zeng et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

Photodynamic antitumor activity of Ru(ii) complexes of imidazo-phenanthroline conjugated hydroxybenzoic acid as tumor targeting photosensitizers

Ze-Yu Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Biochemistry & Molecular Biology

Transferrin and transferrin receptors update

Hiroshi Kawabata

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

The development of the concept of ferroptosis

Tal Hirschhorn et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Engineering, Environmental

Rerouting engineered metal-dependent shapes of mesoporous silica nanocontainers to biodegradable Janus-type (sphero-ellipsoid) nanoreactors for chemodynamic therapy

Chen-Guang Liu et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Ali Raza et al.

MOLECULES (2019)

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Article Chemistry, Multidisciplinary

Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors

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Targeting Ferroptosis to Iron Out Cancer

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Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging

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Mitochondrial metabolism promotes adaptation to proteotoxic stress

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Managing efficacy and toxicity of drugs: Targeted delivery and excretion

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Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition

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Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles

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Perspective of Chiral Colloidal Semiconductor Nanocrystals: Opportunity and Challenge

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Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer

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The role of curcumin and its derivatives in sensory applications

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An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis

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The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

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Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy

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A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors

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Ultralong tumor retention of theranostic nanoparticles with short peptide-enabled active tumor homing

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Targeting cancer vulnerabilities with high-dose vitamin C

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Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

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Ferroptosis promotes photodynamic therapy: supramolecular photosentizer-inducer nanodrug for enhanced cancer treatment

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Tumor Microenvironment-Enabled Nanotherapy

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Artemisinin-Loaded Mesoporous Nanoplatform for pH-Responsive Radical Generation Synergistic Tumor Theranostics

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Dotted Core-Shell Nanoparticles for T-1-Weighted MRI of Tumors

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Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy

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Leveraging -Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells

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Ferroptosis: Death by lipid peroxidation

Brent R. Stockwell

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Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

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Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells

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Apoptosis: A Target for Anticancer Therapy

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Forster Resonance Energy Transfer-Based Dual-Modal Theranostic Nanoprobe for In Situ Visualization of Cancer Photothermal Therapy

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The Role of Ferroptosis in Cancer Development and Treatment Response

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Fluorinated Paramagnetic Complexes: Sensitive and Responsive Probes for Magnetic Resonance Spectroscopy and Imaging

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Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells

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Recent Progress in Fluorescence Imaging of the Near-Infrared II Window

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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity

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CURRENT BIOLOGY (2018)

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Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells

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Elesclomol restores mitochondrial function in genetic models of copper deficiency

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Trends towards Biomimicry in Theranostics

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Wilson disease

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Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

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A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

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Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells

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Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

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Cutting-Edge Nanomaterials for Advanced Multimodal Bioimaging Applications

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Mobilization of Nuclear Copper by Green Tea Polyphenol Epicatechin-3-Gallate and Subsequent Prooxidant Breakage of Cellular DNA: Implications for Cancer Chemotherapy

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Necroptosis in development, inflammation and disease

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Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores

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Paramagnetic 19F Relaxation Enhancement in Nickel(II) Complexes of N-Trifluoroethyl Cyclam Derivatives and Cell Labeling for 19F MRI

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Fe- and Ln-DOTAm-F12 Are Effective Paramagnetic Fluorine Contrast Agents for MRI in Water and Blood

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Chemical Synthesis and Luminescence Applications of Colloidal Semiconductor Quantum Dots

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De-novo and acquired resistance to immune checkpoint targeting

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Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents

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MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

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Polymeric nanocarriers for cancer theranostics

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Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

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Near-infrared fluorophores for biomedical imaging

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Luminescence, Plasmonic, and Magnetic Properties of Doped Semiconductor Nanocrystals

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Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy

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The calcium-cancer signalling nexus

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Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor

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High-Performance Hybrid Bismuth-Carbon Nanotube Based Contrast Agent for X-ray CT Imaging

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Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update

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Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo

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TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel

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Ferroptosis: process and function

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Ferroptosis is an autophagic cell death process

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Mechanisms of ferroptosis

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A CoII complex for 19F MRI-based detection of reactive oxygen species

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Luminescent Colloidal Semiconductor Nanocrystals Containing Copper: Synthesis, Photophysics, and Applications

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Nickel(II) complexes of N-CH2CF3 cyclam derivatives as contrast agents for 19F magnetic resonance imaging

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Expanding roles of superoxide dismutases in cell regulation and cancer

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8-Hydroxyquinolines in medicinal chemistry: A structural perspective

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The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

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Experimental and theoretical studies of copper complexes with isomeric dipeptides as novel candidates against breast cancer

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Contrast agents in diagnostic imaging: Present and future

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Sorption of 3-hydroxyflavone within channel type zeolites: the effect of confinement on copper(II) complexation

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Nanostructure-Based Theranostic Systems

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The Smart Drug Delivery System and Its Clinical Potential

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Hybrid lanthanide nanoparticles as a new class of binary contrast agents for in vivo T-1/T-2 dual-weighted MRI and synergistic tumor diagnosis

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Roles of Zinc Signaling in the Immune System

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Calcium signaling as a mediator of cell energy demand and a trigger to cell death

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MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2015)

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Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy

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In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles

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A Manganese Alternative to Gadolinium for MRI Contrast

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The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the Triad of Death in cancer by Di-2-pyridylketone thiosemicarbazones

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Brain Tumors: Single Ho3+-Doped Upconversion Nanoparticles for High-PerformanceT2-Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging (Adv. Funct. Mater. 42/2014)

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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

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Nanoparticle contrast agents for computed tomography: a focus on micelles

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The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

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Clinical imaging in regenerative medicine

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Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

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Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy

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Modulation of CEST Images in Vivo by T1 Relaxation: A New Approach in the Design of Responsive PARACEST Agents

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Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking

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Chelating Agents as Tools for the Treatment of Metal Overload

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ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE (2013)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs

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The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

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Copper-Dependent Cytotoxicity of 8-Hydroxyquinoline Derivatives Correlates with Their Hydrophobicity and Does Not Require Caspase Activation

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An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

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Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node

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Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)

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Current Molecular Imaging of Spinal Tumors in Clinical Practice

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The Science Behind Hyponatremia and Its Clinical Manifestations

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Design Principles and Theory of Paramagnetic Fluorine-Labelled Lanthanide Complexes as Probes for F-19 Magnetic Resonance: A Proof-of-Concept Study

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Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

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Inorganic Nanoparticles for MRI Contrast Agents

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A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

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Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

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Pyroptosis: host cell death and inflammation

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Semiconductor quantum dots for bioanalysis

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Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

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Elesclomol induces cancer cell apoptosis through oxidative stress

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Mechanisms for copper acquisition, distribution and regulation

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Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

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Calcium signaling

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X-ray computed tomography

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Calcium ion as a second messenger with special reference to excitation-contraction coupling

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Quantum dot bioconjugates for imaging, labelling and sensing

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STIM1, an essential and conserved component of store-operated Ca2+ channel function

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Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

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Mitochondria and calcium: from cell signalling to cell death

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