Global prevalence, characteristics, and future prospects of IncX3 plasmids: A review

IncX3 plasmids are narrow host range plasmids mostly found in Enterobacteriaceae with great conjugation ability, high stability, no fitness cost, and the ability to improve biofilm formation in their bacterial hosts. IncX3 plasmids have spread swiftly, primarily in several nations and among different species over the last 10 years. bla(NDM), bla(KPC), and bla(OXA-181) are the carbapenemase genes carried by IncX3 plasmids. Among them, bla(NDM) is often located on the IncX3 plasmid, which is deemed as the primary vehicle of bla(NDM) transmission. Isolates harboring IncX3 plasmids are found in nations all over the world from human, animal, and environmental sources. Cointegrate plasmids related to IncX3 have recently been discovered to increase the antibiotic resistance spectrum and potentially broaden the host range of plasmids, restricting the use of antibiotics in the clinic. There are, however, few reviews based on the physiological and epidemiological properties of IncX3 plasmid, as well as studies on the plasmid itself. Hence, we conducted a retrospective literature review to summarize the characteristics of IncX3 plasmids aiming to provide a theoretical basis for controlling the global prevalence of IncX3 plasmids and directions for further research on the functions of the related genes on the IncX3 plasmid.

Automated summary

IncX3 plasmids, with great conjugation ability and high stability, are narrow host range plasmids mostly found in Enterobacteriaceae. They have the ability to improve biofilm formation in their bacterial hosts. The carbapenemase genes bla(NDM), bla(KPC), and bla(OXA-181) can be carried by IncX3 plasmids. IncX3 plasmids have spread rapidly among different species in several nations over the past decade. Cointegrate plasmids related to IncX3 have been found to increase antibiotic resistance and potentially broaden the plasmids' host range.