Journal
FRONTIERS IN MICROBIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.1006765
Keywords
lipoproteins; lipopeptides; Staphylococcus aureus; infection; immunity; TLR2; host-pathogen interactions; metabolic fitness
Categories
Funding
- Swedish Medical Research Council [523-2013-2750]
- Swedish Government [ALFGBG-823941, ALFGBG-926621]
- Swedish county councils, the ALF-agreement [ALFGBG-823941, ALFGBG-926621]
- E och K.G. Lennanders stipendiestiftelse
- Sahlgrenska University Hospital Foundations
- Rune och Ulla Amloevs Stiftelse foer Neurologisk, Reumatologisk och Audiologisk Forskning
- Kungl. Vetenskapsakademiens stiftelser [ME2015-0119]
- Inger Bendix Stiftelse foer Medicinsk Forskning
- Magnus Bergvalls Stiftelse [2017-01958, 2018-02797]
- Institute of Medicine, Gothenburg University
- Medical Faculty Muenster [NG 122106]
- Deutsche Forschungsgemeinschaft the Germany's Excellence Strategy [EXC 2124, 390838134]
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Infections with the Gram-positive bacterial pathogen Staphylococcus aureus pose a significant challenge to the healthcare system, especially due to the increasing antibiotic resistance. This study focuses on bacterial lipoproteins (Lpps) of S. aureus, which play a role in both immune response and disease pathogenesis. The specific roles of Lpps in various staphylococcal infections are still not well-defined.
Infections with the Gram-positive bacterial pathogen Staphylococcus aureus remain a major challenge for the healthcare system and demand new treatment options. The increasing antibiotic resistance of S. aureus poses additional challenges, consequently inflicting a huge strain in the society due to enormous healthcare costs. S. aureus expresses multiple molecules, including bacterial lipoproteins (Lpps), which play a role not only in immune response but also in disease pathogenesis. S. aureus Lpps, the predominant ligands of TLR2, are important for bacterial survival as they maintain the metabolic activity of the bacteria. Moreover, Lpps possess many diverse properties that are of vital importance for the bacteria. They also contribute to host cell invasion but so far their role in different staphylococcal infections has not been fully defined. In this review, we summarize the current knowledge about S. aureus Lpps and their distinct roles in various infectious disease animal models, such as septic arthritis, sepsis, and skin and soft tissue infections. The molecular and cellular response of the host to S. aureus Lpp exposure is also a primary focus.
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