Journal
FRONTIERS IN MICROBIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.964019
Keywords
phenylacetic acid pathway; aromatic metabolites; enzyme structure; pathogenicity; antibiotic resistance
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Phenylacetic acid (PAA) plays a crucial role in bacterial metabolism, and its pathway consists of several enzymes and a transcriptional regulator. These components are widely present in bacterial genomes and are involved in biofilm formation and antimicrobial activity. The enzymes of the PAA pathway have potential as antimicrobial drug targets in metabolic engineering.
Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approximately 16% of the sequenced bacterial genome. In this review, we have summarized the PAA distribution in microbes, recent structural and functional study progress of the enzyme families of the bacterial PAA pathway, and their role in bacterial pathogenicity and antibiotic resistance. The enzymes of the bacterial PAA pathway have shown potential as an antimicrobial drug target for biotechnological applications in metabolic engineering.
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