4.6 Review

Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential

Journal

FRONTIERS IN MICROBIOLOGY
Volume 13, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.1040093

Keywords

hemorrhagic fever viruses; viral hemorrhagic fevers; fatal viral disease; emerging; re-emerging infectious diseases

Categories

Funding

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2022/01812-8, 2015/26722-8, 2017/03966-4, 2020/12277-0, 2018/18257-1, 2018/15549-1, 2020/04923-0, 2020/06409-1, 2019/12303-4, 2017/27131-9, 2016/20045-7, 2016/08730-6]
  2. Conselho Nacional de Ciencia e Tecnologia (CNPq) [305,430/2019-0]
  3. Fundacao Butantan
  4. NIH [404,176/2019-4, 1 R01 AI149608-01]
  5. [307,854/2018-3]
  6. [301,524/2019-0]

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This article discusses the pathogenesis and treatment options for viral hemorrhagic fevers caused by hemorrhagic fever viruses (HFVs), as well as the potential for these viruses to cause global emergencies and factors favoring their spread beyond their original niches.
Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

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