4.7 Review

Modulation of autophagy as a therapeutic strategy for Toxoplasma gondii infection

Related references

Note: Only part of the references are listed.
Article Parasitology

Polyether ionophore kijimicin inhibits growth of Toxoplasma gondii and controls acute toxoplasmosis in mice

Arpron Leesombun et al.

Summary: The evaluation of natural polyether ionophore antibiotics against Toxoplasma gondii revealed that kijimicin and monensin significantly inhibited the parasite growth and invasion, with kijimicin showing superior activity. Additionally, both compounds induced changes in mitochondrial membrane potential and reactive oxygen species generation in the parasites. Furthermore, in vivo studies showed that kijimicin treatment improved survival rates in mice infected with T. gondii, suggesting its potential as a new drug for controlling the parasite growth.

PARASITOLOGY RESEARCH (2022)

Review Immunology

Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced by Toxoplasma gondii

Kun Yin et al.

Summary: Toxoplasma gondii has a complex life cycle and can infect a wide range of warm-blooded animals globally. Infection by this parasite has been linked to various psychiatric disorders, such as schizophrenia and suicide. The mechanism behind the parasite's manipulation effects has not been fully elucidated. Recent research suggests that neuroendocrine programs and neurotransmitter imbalance may play a key role in this process. Additionally, studying the expression patterns of host genes, long noncoding RNAs (lncRNAs), and mRNAs provides new insights into understanding the neurotransmitter dysfunction induced by parasite manipulation.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Oncology

An overview of autophagy: Mechanism, regulation and research progress

Weiya Cao et al.

Summary: Autophagy is a process in cells where autophagosomes are formed to degrade cellular contents for cell homeostasis. It involves complex regulatory mechanisms and multiple signaling pathways. Autophagy and apoptosis share common stimulating factors and regulatory proteins, but differ in their induction thresholds.

BULLETIN DU CANCER (2021)

Article Integrative & Complementary Medicine

Inhibitory Effects of Inonotus obliquus Polysaccharide on Inflammatory Response in Toxoplasma gondii-Infected RAW264.7 Macrophages

Kexin Yan et al.

Summary: The study demonstrated that Inonotus obliquus polysaccharide (IOP) has anti-inflammatory effects in T. gondii-infected RAW264.7 macrophages by regulating the TLR2/TLR4-NF-kappa B/MAPKs pathways.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Article Multidisciplinary Sciences

Adverse outcomes associated with the treatment of Toxoplasma infections

Ahmed M. Shammaa et al.

Summary: This study used real-world data from the FAERS database to analyze adverse outcomes and events associated with the treatment of Toxoplasma infections. Findings suggest that clindamycin and pyrimethamine may be strongly associated with death, and sulfonamide formulations may have a less favorable safety profile.

SCIENTIFIC REPORTS (2021)

Article Microbiology

T-bet-dependent ILC1-and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii

Americo H. Lopez-Yglesias et al.

Summary: The study demonstrates that early T-bet-dependent production of IFN-gamma by ILC1 and NK cells is essential for maintaining inflammatory DCs during infection, ultimately contributing to host resistance against the parasite Toxoplasma gondii. T-bet-dependent IFN-gamma plays a critical role in inducing IRF8 and sustaining inflammatory DCs at the infection site, protecting against acute susceptibility to T. gondii infection.

PLOS PATHOGENS (2021)

Article Biochemistry & Molecular Biology

Molecular chaperone function of stress inducible Hsp70 is critical for intracellular multiplication of Toxoplasma gondii

Pallabi Mitra et al.

Summary: Intracellular pathogens like Toxoplasma gondii manipulate host cell survival and stress response by targeting molecular chaperones such as Heat shock proteins (Hsps), particularly Hsp70. This study demonstrates that the selective inhibitor PES disrupts Hsp70 function, leading to dysregulation of host autophagy and attenuation of T. gondii multiplication. Interestingly, PES targets not only host Hsp70 but also the parasite's Hsp70 homologue, highlighting the potential of dual targeting for therapeutic interventions.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Review Immunology

Advances in Toxoplasma gondii Vaccines: Current Strategies and Challenges for Vaccine Development

Ki-Back Chu et al.

Summary: Toxoplasmosis, caused by the apicomplexan parasite Toxoplasma gondii, is a globally important parasite-borne zoonotic disease, with approximately one-third of the world's population estimated to be infected with T. gondii. Efforts to develop a vaccine for T. gondii have been ongoing for decades, with various strategies tested in rodents showing promising results. However, the translation of these results into clinical studies remains a major obstacle to overcome for the development of a human vaccine.

VACCINES (2021)

Review Biochemistry & Molecular Biology

Oxidative Stress as a Possible Target in the Treatment of Toxoplasmosis: Perspectives and Ambiguities

Karolina Szewczyk-Golec et al.

Summary: Toxoplasma gondii is a common cause of disease, with severity depending on the patient's immune status. Limited treatment options have led to an exploration of the role of oxidative stress in pathophysiology and treatment. Research suggests that chemical compounds modifying redox status may be potential drugs, while natural antioxidants like melatonin and vitamins are also being considered as novel therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Myrislignan Induces Redox Imbalance and Activates Autophagy in Toxoplasma gondii

Jili Zhang et al.

Summary: Research suggests that myrislignan has anti-Toxoplasma gondii properties by affecting its oxidation-reduction process and inducing autophagy, ultimately leading to the parasite's death.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Cell Biology

Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications

Carlos S. Subauste

Summary: Toxoplasma gondii is an intracellular protozoan that can cause encephalitis and retinitis in humans, depending on its ability to form a parasitophorous vacuole for protection and replication. The vacuole can be targeted by autophagy, but the parasite has developed strategies to preserve its integrity. Recent advances have highlighted the importance of autophagy in regulating invasion into the brain and retina by T. gondii, with potential therapeutic applications being explored.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

Licarin-B Exhibits Activity Against the Toxoplasma gondii RH Strain by Damaging Mitochondria and Activating Autophagy

Jili Zhang et al.

Summary: Licarin-B from nutmeg exhibited excellent anti-Toxoplasma gondii activity both in vitro and in vivo, potentially functioning by damaging mitochondria and activating autophagy, leading to parasite death.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo

Yuan Liu et al.

Summary: The study identified a novel spider peptide, XYP1, with potent anti-Toxoplasma activity both in vitro and in vivo. XYP1 inhibited the viability, invasion, and proliferation of tachyzoites with low cytotoxicity on human host cells and improved the survival rate of mice infected with T. gondii. Further exploration of the mechanism revealed XYP1 causes membrane perforation, swelling, and disruption of tachyzoites, potentially through differential expression of membrane-associated proteins including HSP29. Overall, XYP1 shows promise as a new drug candidate for toxoplasmosis treatment.

BIOMEDICINES (2021)

Article Engineering, Biomedical

Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis

Aziza A. M. El-Shafey et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2020)

Article Pharmacology & Pharmacy

AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication

Jonathan O. Rayner et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Oncology

Targeting ATG4 in Cancer Therapy

Yuanyuan Fu et al.

CANCERS (2019)

Article Biochemistry & Molecular Biology

Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis

Honit Piplani et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Article Microbiology

Direct and Indirect Inhibition Effects of Resveratrol against Toxoplasma gondii Tachyzoites In Vitro

Qi-Wei Chen et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Review Immunology

Host immune responses to Toxoplasma gondii

Miwa Sasai et al.

INTERNATIONAL IMMUNOLOGY (2018)

Article Psychiatry

Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia

Jianchun Xiao et al.

SCHIZOPHRENIA BULLETIN (2018)

Review Microbiology

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice

Ildiko Rita Dunay et al.

CLINICAL MICROBIOLOGY REVIEWS (2018)

Article Chemistry, Medicinal

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

Joshua B. Radke et al.

ACS INFECTIOUS DISEASES (2018)

Article Nanoscience & Nanotechnology

Curcumin nanoemulsion as a novel chemical for the treatment of acute and chronic toxoplasmosis in mice

Sanaz Jafarpour Azami et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Article Cell Biology

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Niccolo Pengo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

In vitro activity of the interaction between taxifolin (dihydroquercetin) and pyrimethamine against Toxoplasma gondii

Daniel A. Abugri et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2018)

Article Multidisciplinary Sciences

Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells

Francesca Ietta et al.

SCIENTIFIC REPORTS (2017)

Article Microbiology

Statins and Voriconazole Induce Programmed Cell Death in Acanthamoeba castellanii

Carmen M. Martin-Navarro et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Review Biochemistry & Molecular Biology

Oxidative stress and autophagy: the clash between damage and metabolic needs

G. Filomeni et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Biochemistry & Molecular Biology

Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease

Sumeet A. Khetarpal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Cell Biology

Sirtuins' Modulation of Autophagy

Fanny Ng et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

Wafa B'chir et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Immunology

Autophagy in infection, inflammation and immunity

Vojo Deretic et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Parasitology

Proliferation of Toxoplasma gondii Suppresses Host Cell Autophagy

Youn-Jin Lee et al.

KOREAN JOURNAL OF PARASITOLOGY (2013)

Editorial Material Biochemistry & Molecular Biology

The cost of living longer Fertility trades with immunity and life expectancy

Philip Hunter

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates

Min Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Letter Infectious Diseases

Statins inhibit Toxoplasma gondii multiplication in macrophages in vitro

Erika Cortez et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)

Article Microbiology

The History of Toxoplasma gondii-The First 100 Years

Jitender P. Dubey

JOURNAL OF EUKARYOTIC MICROBIOLOGY (2008)

Article Multidisciplinary Sciences

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

J. P. J. Saeij et al.

NATURE (2007)

Article Infectious Diseases

Fulminant toxoplasmosis causing fatal pneumonitis and myocarditis

D. E. Eza et al.

HIV MEDICINE (2006)

Article Biochemistry & Molecular Biology

Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx

M Deponte et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2005)

Article Biochemistry & Molecular Biology

Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii

SE Akerman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii

A Khan et al.

NUCLEIC ACIDS RESEARCH (2005)

Review Medicine, General & Internal

Toxoplasmosis

JG Montoya et al.

LANCET (2004)

Article Biochemistry & Molecular Biology

Two glycoforms are present in the GPI-membrane anchor of the surface antigen 1 (P30) of Toxoplasma gondii

CF Zinecker et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2001)