Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.998313
Keywords
periodontitis; Porphyromonas gingivalis; vascular endothelial cells; vascular endothelial dysfunction; vascular disease
Categories
Funding
- National Natural Science Foundation of China
- Foundation of Beijing Tongren Hospital, Capital Medical University
- [82170957]
- [81870772]
- [2021-YJJ-ZZL-047]
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Periodontitis, an oral inflammatory disease, is associated with dysregulation of host immunoinflammatory response. It is harmful to both oral health and the onset and progress of various vascular diseases. This review aims to focus on the implications of periodontitis in vascular endothelial dysfunction.
Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.
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