4.8 Article

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

Related references

Note: Only part of the references are listed.
Review Anatomy & Morphology

Empowering Muscle Stem Cells for the Treatment of Duchenne Muscular Dystrophy

Romina L. Filippelli et al.

Summary: DMD is a devastating muscle degenerative disease with no effective cure. Defective expression of the DMD gene and impaired muscle stem cell function contribute to the progression of the disease. Restoring muscle stem cell function may serve as a viable regenerative medicine strategy to mitigate DMD.

CELLS TISSUES ORGANS (2023)

Article Pathology

Early Inflammation in Muscular Dystrophy Differs between Limb and Respiratory Muscles and Increases with Dystrophic Severity

Zachary M. Howard et al.

Summary: The study found that mdx and Het mice have increased levels of chemokines and cytokines, with Het mice showing higher levels. Additionally, Het quadriceps contain more neutrophils and infiltrating monocytes, and have higher fibrotic and inflammatory gene expression levels in myeloid cells. These differences may affect the regenerative potential of dystrophic diaphragms and represent an improved model for testing anti-inflammatory therapies for DMD.

AMERICAN JOURNAL OF PATHOLOGY (2021)

Article Multidisciplinary Sciences

Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging

Ivana Dabaj et al.

Summary: This study investigated the metabolic changes in Duchenne muscular dystrophy (DMD) using mass spectrometry-based imaging, revealing significant alterations in key metabolites related to energy and phospholipid metabolism. The findings indicate a deep metabolic remodeling in phospholipids and energy metabolism in DMD. The systems-based approach allowed for exploring the metabolism in DMD in a comprehensive and unbiased manner.

SCIENTIFIC REPORTS (2021)

Article Geriatrics & Gerontology

Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset

Virginie Mournetas et al.

Summary: This study utilized cells from DMD patients and induced pluripotent stem cells to investigate the pathogenesis of DMD through multi-omic analysis, revealing that pathological changes of DMD start as early as the embryonic stage, suggesting a need to reconsider the role of dystrophin in muscle development.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Biochemical Research Methods

Multimodal regularized linear models with flux balance analysis for mechanistic integration of omics data

Giuseppe Magazzu et al.

Summary: The study demonstrates the competitiveness and ease of interpretation of multimodal regularized linear models in multiomic regression tasks compared to data-hungry methods based on neural networks.

BIOINFORMATICS (2021)

Article Cell Biology

Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells

Bart Lagerwaard et al.

Summary: The study suggests that protein propionylation and propionyl-CoA may play important roles in muscle cell differentiation and aging through regulation of histone acylation.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Biochemistry & Molecular Biology

Genome-scale metabolic modelling of SARS-CoV-2 in cancer cells reveals an increased shift to glycolytic energy production

Elisabeth Yaneske et al.

Summary: The study examined the interaction between COVID-19 and cancer, revealing metabolic alterations triggered by SARS-CoV-2 infection, as well as the impact on cellular biology and energy production pathways.

FEBS LETTERS (2021)

Review Biochemistry & Molecular Biology

The regulatory role of Myomaker and Myomixer-Myomerger-Minion in muscle development and regeneration

Bide Chen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Article Biochemistry & Molecular Biology

An atlas of human metabolism

Jonathan L. Robinson et al.

SCIENCE SIGNALING (2020)

Article Clinical Neurology

Early developmental milestones in Duchenne muscular dystrophy

Paula van Dommelen et al.

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2020)

Article Multidisciplinary Sciences

Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss

Ryan T. Massopust et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Human myotube formation is determined by MyoD-Myomixer/Myomaker axis

Haifeng Zhang et al.

SCIENCE ADVANCES (2020)

Article Biochemistry & Molecular Biology

Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling

Justyna Rog et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Biochemistry & Molecular Biology

Genomic Imprinting and Physiological Processes in Mammals

Valter Tucci et al.

Article Biochemical Research Methods

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Laurent Heirendt et al.

NATURE PROTOCOLS (2019)

Review Biochemical Research Methods

Machine and deep learning meet genome-scale metabolic modeling

Guido Zampieri et al.

PLOS COMPUTATIONAL BIOLOGY (2019)

Review Genetics & Heredity

Transcriptional Control by Premature Termination: A Forgotton Mechanism

Kinga Kamieniarz-Gdula et al.

TRENDS IN GENETICS (2019)

Article Multidisciplinary Sciences

Muscle satellite cells and impaired late stage regeneration in different murine models for muscular dystrophies

Antonio F. Ribeiro Jr et al.

SCIENTIFIC REPORTS (2019)

Article Biotechnology & Applied Microbiology

Three-dimensional spherical gelatin bubble-based scaffold improves the myotube formation of H9c2 myoblasts

Chieh Mei et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Article Biochemistry & Molecular Biology

Dystrophinopathy-associated dysfunction of Krebs cycle metabolism

Angus Lindsay et al.

HUMAN MOLECULAR GENETICS (2019)

Article Multidisciplinary Sciences

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Philippe E. Mangeot et al.

NATURE COMMUNICATIONS (2019)

Article Cell & Tissue Engineering

The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment

Natasha C. Chang et al.

CELL STEM CELL (2018)

Article Multidisciplinary Sciences

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Milica Tosic et al.

NATURE COMMUNICATIONS (2018)

Article Neurosciences

Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

Rasha Al-Khalidi et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Article Cell Biology

Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition

Christopher N. J. Young et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation

Huiling Qiu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Improving the phenotype predictions of a yeast genome-scale metabolic model by incorporating enzymatic constraints

Benjamin J. Sanchez et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

Article Multidisciplinary Sciences

Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit

Tobias Otto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell Biology

LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription

Isabella Scionti et al.

CELL REPORTS (2017)

Review Immunology

Regulation of muscle growth and regeneration by the immune system

James G. Tidball

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease

Abena Nsiah-Sefaa et al.

BIOSCIENCE REPORTS (2016)

Article Cell Biology

A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility

Alexander P. Nesmith et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Medicine, Research & Experimental

COUP-TRI regulates satellite cell function and muscular dystrophy

Xin Xie et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Multidisciplinary Sciences

Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle

Erik P. Rader et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

Satellite Cells in Muscular Dystrophy - Lot in Polarity

Natasha C. Chang et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Cell Biology

Epigenetics and Human Disease

Huda Y. Zoghbi et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Article Endocrinology & Metabolism

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

Robert S. Lee-Young et al.

MOLECULAR METABOLISM (2016)

Article Medicine, Research & Experimental

Dystrophin: The dead calm of a dogma

Dariusz C. Gorecki

RARE DISEASES (2016)

Review Cell & Tissue Engineering

Targeting muscle stem cell intrinsic defects to treat Duchenne muscular dystrophy

Nicolas A. Dumont et al.

NPJ REGENERATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Store-operated calcium entry contributes to abnormal Ca2+ signalling in dystrophic mdx mouse myoblasts

Marta Onopiuk et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)

Article Biochemistry & Molecular Biology

Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype

Natassia M. Vieira et al.

Review Developmental Biology

Intrinsic and extrinsic mechanisms regulating satellite cell function

Nicolas A. Dumon et al.

DEVELOPMENT (2015)

Review Cell Biology

Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy

Joe W. McGreevy et al.

DISEASE MODELS & MECHANISMS (2015)

Article Multidisciplinary Sciences

An integrated map of structural variation in 2,504 human genomes

Peter H. Sudmant et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

Nicolas A. Dumont et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Predictive analytics of environmental adaptability in multi-omic network models

Claudio Angione et al.

SCIENTIFIC REPORTS (2015)

Article Medicine, General & Internal

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

Anthony Sinadinos et al.

PLOS MEDICINE (2015)

Review Biochemistry & Molecular Biology

Dysregulation of calcium homeostasis in muscular dystrophies

Ainara Vallejo-Illarramendi et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2014)

Article Biochemistry & Molecular Biology

Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy

Trent A. Waugh et al.

HUMAN MOLECULAR GENETICS (2014)

Article Genetics & Heredity

Dystrophin is a tumor suppressor in human cancers with myogenic programs

Yuexiang Wang et al.

NATURE GENETICS (2014)

Review Rheumatology

The skeletal muscle arachidonic acid cascade in health and inflammatory disease

Marina Korotkova et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemical Research Methods

Software for Computing and Annotating Genomic Ranges

Michael Lawrence et al.

PLOS COMPUTATIONAL BIOLOGY (2013)

Article Cell Biology

P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment

Christopher N. J. Young et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Multidisciplinary Sciences

Complex Interactions between Human Myoblasts and the Surrounding 3D Fibrin-Based Matrix

Stephane Chiron et al.

PLOS ONE (2012)

Article Cell & Tissue Engineering

Characterization of human myoblast differentiation for tissue-engineering purposes by quantitative gene expression analysis

Jens Stern-Straeter et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2011)

Article Multidisciplinary Sciences

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

Fran Supek et al.

PLOS ONE (2011)

Article Biochemical Research Methods

Computationally efficient flux variability analysis

Steinn Gudmundsson et al.

BMC BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

Alessandra Sacco et al.

Article Genetics & Heredity

Muscle histology in fetuses at risk for Duchenne muscular dystrophy

James Toop et al.

CLINICAL GENETICS (2010)

Article Biochemistry & Molecular Biology

Mutation in dystrophin-encoding gene affects energy metabolism in mouse myoblasts

Marta Onopiuk et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Biochemistry & Molecular Biology

Decorin modulates collagen matrix assembly and mineralization

Yoshiyuki Mochida et al.

MATRIX BIOLOGY (2009)

Article Biochemistry & Molecular Biology

SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin

Dali Li et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Biochemistry & Molecular Biology

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology

Mohammad M. Ghahramani Seno et al.

HUMAN MOLECULAR GENETICS (2008)

Article Multidisciplinary Sciences

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

Claudia Colussi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Bex1 knock out mice show altered skeletal muscle regeneration

Jae Hyung Koo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

G. C. Minetti et al.

NATURE MEDICINE (2006)

Article Multidisciplinary Sciences

SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos

XG Tan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

An efficient SNP system for mouse genome scanning and elucidating strain relationships

PM Petkov et al.

GENOME RESEARCH (2004)

Article Cell Biology

Dynamic interaction of HMGA1a proteins with chromatin

M Harrer et al.

JOURNAL OF CELL SCIENCE (2004)

Article Pathology

Inactivation of phosphoglycerate mutase and creatine kinase isoenzymes in human serum

N Durany et al.

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY (2002)

Article Pathology

Muscle lesions associated with dystrophin deficiency in neonatal golden retriever puppies

F Nguyen et al.

JOURNAL OF COMPARATIVE PATHOLOGY (2002)