Extrachromosomal circular DNA: Current status and future prospects

Review Pathology

Extrachromosomal DNA: An Emerging Hallmark in Human Cancer

Sihan Wu et al.

Summary: This review discusses the formation and function of circular, extrachromosomal pieces of DNA (ecDNA) found in cancer, as well as their contribution to tumor pathogenesis, drug resistance, and accelerated cancer evolution.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

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Article Biochemical Research Methods

ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data

Ludwig Mann et al.

Summary: The study presents a bioinformatics pipeline called ECCsplorer for detecting eccDNAs in any organism or tissue using next-generation sequencing data. The pipeline allows easy and automated discovery of eccDNA candidates and demonstrates high sensitivity and specificity.

BMC BIOINFORMATICS (2022)

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Article Biochemistry & Molecular Biology

CircleBase: an integrated resource and analysis platform for human eccDNAs

Xiaolu Zhao et al.

Summary: CircleBase is an integrated resource and analysis platform for curating and interpreting eccDNAs in multiple cell types. It identifies putative functional eccDNAs by incorporating sequencing datasets, computational predictions, and manual annotations, and classifies them into six sections including targeting genes, epigenetic regulations, and more. The top-ranked cancer cell eccDNAs were found to be enriched in oncogenic pathways such as the Ras and PI3K-Akt signaling pathways, while eccDNAs from healthy individuals were not significantly enriched.

NUCLEIC ACIDS RESEARCH (2022)

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Article Oncology

Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer

Eunhee Yi et al.

Summary: Oncogenic ecDNA plays a crucial role in tumor evolution, but our understanding of its biology is limited. In this study, we investigated the distribution and frequency of ecDNA copy number in patient tissues and cell line models. We discovered uneven segregation of ecDNA during mitosis and the formation of ecDNA hubs that drive oncogene transcription.

CANCER DISCOVERY (2022)

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Review Cell Biology

Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

Shanru Zuo et al.

Summary: Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA derived from chromosomes, with strong heterogeneity in sequence, length, and origin, and has been identified in both normal and cancer cells. Recent technological advancements have highlighted the potential role of eccDNA in cancers by regulating oncogene expression, chromosome accessibility, genome replication, immune response, and cellular communications. However, the functional relevance of eccDNA remains to be fully elucidated.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Plant Sciences

Diverse and mobile: eccDNA-based identification of carrot low-copy-number LTR retrotransposons active in callus cultures

Kornelia Kwolek et al.

Summary: Long terminal repeat retrotransposons (LTR-RTs) make up a significant portion of repetitive DNA in plant genomes, including the carrot genome. Certain LTR-RT lineages have been active in carrots and have contributed to genome diversity. Low-copy-number LTR-RT subfamilies, such as those belonging to the DcAle lineage, have played a significant role in this diversity.

PLANT JOURNAL (2022)

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Review Cell Biology

A unifying model for extrachromosomal circular DNA load in eukaryotic cells

Gerard Arrey et al.

Summary: Extrachromosomal circular DNA (eccDNA) with exons and whole genes is a common feature in eukaryotic cells. Researchers have found that eccDNA can provide selective advantages and disadvantages, and it has the ability to quickly change copy number and incorporate secondary mutations into chromosomes. A proposed 5-factor model emphasizes the formation, replication, segregation, selection, and elimination of eccDNA, providing a framework for further research on its biology and factors that affect eccDNA load in eukaryotic cells.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Review Genetics & Heredity

Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

Julie B. Noer et al.

Summary: Extrachromosomal circular DNA (eccDNA) plays important roles in cancer pathogenesis, tumor heterogeneity evolution, and therapeutic resistance. This review provides an overview of the different names, formation mechanisms, and research methods of eccDNA, as well as explores its potential clinical value.

TRENDS IN GENETICS (2022)

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Article Cell Biology

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy

Changwei Lin et al.

Summary: Our study discovered that extrachromosomal circular DNA (eccDNA) may promote cisplatin (DDP) resistance in hypopharyngeal squamous cell carcinoma (HSCC) by amplifying related functional genes and inducing autophagy. These findings provide a theoretical basis for further exploring the role of eccDNA in drug resistance in HSCC.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression

Tao Wu et al.

Summary: Extrachromosomal DNA (ecDNA) is a tumor-specific genetic element associated with immune evasion. Tumors with ecDNA have lower immune cell infiltration and cytotoxic T cell activity, potentially due to decreased expression of MHC antigen presentation genes.

SCIENTIFIC REPORTS (2022)

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Article Genetics & Heredity

Transposable element landscapes in aging Drosophila

Nachen Yang et al.

Summary: This study reveals that genetic mechanisms that repress transposable elements (TEs) decline during aging, leading to increased TE expression. However, despite the increase in TE transcripts, small RNA and RNAi mechanisms may mitigate genomic TL expansion during aging.

PLOS GENETICS (2022)

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Article Genetics & Heredity

Characterization of Plasma Extrachromosomal Circular DNA in Gouty Arthritis

Jingyuan Pang et al.

Summary: In this study, we used the Circle-Seq approach to detect a large number of eccDNAs from the plasma of gout patients and healthy controls. Further analysis showed no significant difference in genomic element annotation between the gout and control groups. Additionally, we identified some gout-specific eccDNA-associated genes that may play important roles in inflammation and immune response.

FRONTIERS IN GENETICS (2022)

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Article Medicine, Research & Experimental

Effects of nucleases on cell-free extrachromosomal circular DNA

Sarah T. K. Sin et al.

Summary: This study investigates the relationship between nucleases and extrachromosomal circular DNA (eccDNA) characteristics in plasma. The results show that DNASE1L3 can digest extracellular eccDNA but does not seem to affect intracellular eccDNA. The study also highlights the systemic effects of circulating fetal DNASE1L3 in degrading maternal eccDNA. Patients with DNASE1L3 mutations exhibit longer size distributions of plasma eccDNA compared to healthy controls. Overall, this study provides a missing link between nuclease activity and the biological manifestations of eccDNA in plasma, laying the foundation for future biomarker development.

JCI INSIGHT (2022)

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Article Cell Biology

CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Xin-Yuan Lyu et al.

Summary: In this study, we introduced a robust CRISPR FISHer system for visualization of specific DNA sequences in live cells, achieving enhancements in both brightness and signal-to-background ratio. The system showed excellent performance in labeling and tracking chromosomal fragments during breakage, separation, and rejoining processes.

CELL RESEARCH (2022)

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Article Oncology

Starfish infers signatures of complex genomic rearrangements across human cancers

Lisui Bao et al.

Summary: Bao et. al. developed an algorithm called Starfish to identify six signatures of complex genomic rearrangements in human cancer genomics datasets, with a notable pattern called hourglass chromothripsis found in prostate cancer. The study analyzed 2,014 CGRs from 2,428 whole-genome-sequenced tumors and discovered six CGR signatures based on copy number and breakpoint patterns, with over half belonging to previously unreported signatures.

NATURE CANCER (2022)

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Review Cell Biology

Deciphering the Mechanism of Glyphosate Resistance in Amaranthus palmeri by Cytogenomics

Dal-Hoe Koo et al.

Summary: Glyphosate is commonly used in agriculture to control weeds, but overuse has led to the evolution of glyphosate-resistant weeds. The main resistance mechanism identified is the amplification of the EPSPS gene in Amaranthus palmeri, which has serious implications for agriculture in the USA. Further analysis revealed the presence of extrachromosomal circular DNA containing amplified EPSPS copies, termed EPSPS-eccDNA, which contributes to copy number variation and genetic inheritance in resistant weeds.

CYTOGENETIC AND GENOME RESEARCH (2022)

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Review Oncology

Extra chromosomal DNA in different cancers: Individual genome with important biological functions

Mohsen Karami Fath et al.

Summary: ecDNA, as a pivotal factor in tumor pathogenesis and evolution, amplifies oncogene copy numbers in cancer, thus playing a significant role in understanding the cancer genome landscape. Further exploration of the basic mechanisms of ecDNA may provide additional insights for cancer therapeutics.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Article Medical Laboratory Technology

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Sarah T. K. Sin et al.

Summary: The research found that fetal eccDNA in plasma is relatively hypomethylated compared to maternal eccDNA. The methylation densities of eccDNA are positively correlated with their sizes. Fetal eccDNA is rapidly cleared from maternal blood after delivery, similar to fetal linear DNA.

CLINICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Investigating the origins and evolution of a glyphosate-resistant weed invasion in South America

Todd A. Gaines et al.

Summary: The research on the spread and evolution of glyphosate-resistant Amaranthus palmeri in South America suggests that Argentina may have independently evolved glyphosate resistance and received limited transmission of the resistance mechanism from Brazil. This indicates an initial introduction of A. palmeri into South America before the 1980s, with subsequent local evolution of glyphosate resistance in Argentina and secondary invasion of GR A. palmeri with the unique eccDNA-based mechanism from the USA into Brazil and Uruguay during the 2010s.

MOLECULAR ECOLOGY (2021)

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Article Multidisciplinary Sciences

eccDNAs are apoptotic products with high innate immunostimulatory activity

Yuangao Wang et al.

Summary: By developing a new eccDNA purification and profiling method, the study revealed close-to-random genomic origination, mechanism of biogenesis and function of eccDNAs.

NATURE (2021)

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Article Genetics & Heredity

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer

Carolina Rosswog et al.

Summary: Seismic amplifications are a type of amplification caused by chromothripsis, resulting in circular recombination of circular extrachromosomal DNA, providing a mechanism for oncogene amplification in various human tumor types. In pediatric neuroblastoma data, seismic amplification was characterized by multiple rearrangements and discontinuous copy number levels.

NATURE GENETICS (2021)

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Article Cell Biology

TRPS1 drives heterochromatic origin refiring and cancer genome evolution

Jianguo Yang et al.

Summary: The exploitation of naturally occurring genetic mutations reveals new aspects of established cancer genes. TRPS1, associated with the TRPS syndrome and identified as a breast cancer driver, promotes breast carcinogenesis by regulating replication. Mutations in TRPS affect its chromatin binding, replication boosting, and tumorigenicity, while overexpression of wild-type TRPS1 drives cancer genome amplifications leading to therapeutic resistance.

CELL REPORTS (2021)

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Article Multidisciplinary Sciences

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Xue-Ke Zhao et al.

Summary: Frequent focal amplifications and ecDNAs were identified in Chinese GCA patients, with associations to chromothripsis process and dietary habits. The presence of oncogene focal amplifications in GCA patients showed diverse correlations with prognosis, highlighting ERBB2 focal amplifications as a potential prognostic marker in this population.

NATURE COMMUNICATIONS (2021)

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Article Plant Sciences

ecc_finder: A Robust and Accurate Tool for Detecting Extrachromosomal Circular DNA From Sequencing Data

Panpan Zhang et al.

Summary: Extrachromosomal circular DNA (eccDNA) is observed in different species and may play an important role in rapid adaptation. There is currently no available bioinformatic tool to identify eccDNAs from Nanopore reads, but the ecc_finder tool effectively addresses this issue.

FRONTIERS IN PLANT SCIENCE (2021)

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Article Oncology

Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription

Yanfen Zhu et al.

Summary: The study reveals that extrachromosomal, circular DNA (ecDNA) is a common and oncogenic alteration in cancer genomes, impacting transcriptional programs through chromatin interactions. ecDNAs in neurosphere and prostate cancer cell cultures show widespread intra-ecDNA and genome-wide chromosomal interactions, potentially leading to high-level expression of chromosomal genes.

CANCER CELL (2021)

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Article Immunology

Identification and Characterization of Extrachromosomal Circular DNA in Human Placentas With Fetal Growth Restriction

Huan Yang et al.

Summary: The study identified a large number of eccDNAs/ecDNAs in FGR, highlighting their potential association with factors such as gestational age. These molecules were found to be mainly enriched in immune-related functions and pathways, overlapping with non-coding RNAs.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Extrachromosomal DNA: Redefining the pathogenesis of glioblastoma

Anjali Shiras et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Biochemistry & Molecular Biology

Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer

Xiaoxuan Ling et al.

Summary: eccDNA is a type of circular DNA that is independent of chromosomes but plays important roles in monitoring, early diagnosis, treatment, and prediction of cancer. They are commonly found in both normal and cancer cells, functioning through various mechanisms in stress response, aging, carcinogenesis, and drug resistance during cancer treatment.

MOLECULAR CANCER (2021)

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Article Genetics & Heredity

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

Weitian Chen et al.

Summary: By using the CCDA-seq method, researchers observed significantly different patterns in nucleosome/regulator binding to ecDNA at a single-molecule resolution, deepening the understanding of ecDNA regulatory mechanisms.

EPIGENETICS & CHROMATIN (2021)

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Article Multidisciplinary Sciences

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma

John DeSisto et al.

Summary: Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. Genomic analysis revealed common copy-number alterations and different subgroups based on DNA methylation and transcriptome profiles, suggesting potential therapeutic targets such as microtubule inhibitors and MEK inhibitors. These findings provide insights into the molecular mechanisms of RIGs and potential treatment strategies.

NATURE COMMUNICATIONS (2021)

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Review Veterinary Sciences

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions

Xiukai Cao et al.

Summary: Extrachromosomal circular DNA (eccDNA), a type of double-stranded circular DNA derived from and separate from chromosomes, is common in eukaryotes with strong heterogeneity in count, length, and origin. It has been shown to play important roles in various biological processes in eukaryotic cells.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Oncology

Extrachromosomal circular DNAs are common and functional in esophageal squamous cell carcinoma

Zhenguo Sun et al.

Summary: This study identified the presence of eccDNAs in ESCC, explored their differential expression, and revealed potential mechanisms in ESCC development. These findings provide insights into genome plasticity and the role of eccDNAs in ESCC, offering potential targets for clinical therapies.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform

Xiaoying Fan et al.

Summary: There is currently no effective method to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. However, the newly developed SMOOTH-seq method shows promise in reliably and effectively detecting SVs and ecDNAs in individual cells, while having relatively limited accuracy in detecting CNVs and SNVs. SMOOTH-seq opens up new possibilities for single-cell whole-genome sequencing by providing high fidelity reads of kilobases long.

GENOME BIOLOGY (2021)

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Article Biology

ATAC-Seq-based Identification of Extrachromosomal Circular DNA in Mammalian Cells and Its Validation Using Inverse PCR and FISH

Zhangli Su et al.

Summary: Recent studies have highlighted the importance of eccDNA from yeast to humans, particularly in cancer cells where oncogenes are amplified on eccDNA causing genomic instability. A new method independent of rolling circle amplification was developed by the research team, utilizing ATAC-seq and a Circle_finder algorithm to predict eccDNA, followed by validation through inverse PCR and FISH.

BIO-PROTOCOL (2021)

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Article Evolutionary Biology

Near-Random Distribution of Chromosome-Derived Circular DNA in the Condensed Genome of Pigeons and the Larger, More Repeat-Rich Human Genome

Henrik Devitt Moller et al.

GENOME BIOLOGY AND EVOLUTION (2020)

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Article Multidisciplinary Sciences

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Sarah T. K. Sin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Biochemistry & Molecular Biology

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

Quratul Ain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

The EccDNA Replicon: A Heritable, Extranuclear Vehicle That Enables Gene Amplification and Glyphosate Resistance in Amaranthus palmeri

William T. Molin et al.

PLANT CELL (2020)

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Editorial Material Multidisciplinary Sciences

Cytokine release syndrome in severe COVID-19

John B. Moore et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Pankaj Kumar et al.

SCIENCE ADVANCES (2020)

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Article Biochemical Research Methods

Full-length sequencing of circular DNA viruses and extrachromosomal circular DNA using CIDER-Seq

Devang Mehta et al.

NATURE PROTOCOLS (2020)

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Review Biochemistry & Molecular Biology

Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression

Zhenyu Liao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Review Genetics & Heredity

Long-read human genome sequencing and its applications

Glennis A. Logsdon et al.

NATURE REVIEWS GENETICS (2020)

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Article Multidisciplinary Sciences

Homogeneity among glyphosate-resistantAmaranthus palmeriin geographically distant locations

William T. Molin et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications

Jens Luebeck et al.

NATURE COMMUNICATIONS (2020)

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Article Biology

Autonomous replication sequences from theAmaranthus palmerieccDNA replicon enable replication in yeast

William T. Molin et al.

BMC RESEARCH NOTES (2020)

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Article Biochemistry & Molecular Biology

Complex mosaic structural variations in human fetal brains

Shobana Sekar et al.

GENOME RESEARCH (2020)

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Article Genetics & Heredity

Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors

Seyed Mohammad Kazem Aghamir et al.

EPIGENETICS INSIGHTS (2020)

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Article Biochemistry & Molecular Biology

Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters

Teressa Paulsen et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Acoustics

Premature placental aging in term small-for-gestational-age and growth-restricted fetuses

C. Paules et al.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2019)

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Article Biochemistry & Molecular Biology

Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA

V. Talya Yerlici et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

Andrew R. Morton et al.

CELL (2019)

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Article Biochemical Research Methods

Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads

Inigo Prada-Luengo et al.

BMC BIOINFORMATICS (2019)

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Article Multidisciplinary Sciences

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Viraj Deshpande et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Transcription-induced formation of extrachromosomal DNA during yeast ageing

Ryan M. Hull et al.

PLOS BIOLOGY (2019)

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Review Oncology

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution

Roel G. W. Verhaak et al.

NATURE REVIEWS CANCER (2019)

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Article Cell Biology

DNA plasticity and damage in amyotrophic lateral sclerosis

Alexandra Kretz et al.

Neural Regeneration Research (2018)

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Article Multidisciplinary Sciences

Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weed Amaranthus palmeri

Dal-Hoe Koo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Genetics & Heredity

Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells

Teressa Paulsen et al.

TRENDS IN GENETICS (2018)

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Article Multidisciplinary Sciences

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Henrik Devitt Moller et al.

NATURE COMMUNICATIONS (2018)

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Article Genetics & Heredity

Sequencing the extrachromosomal circular mobilome reveals retrotransposon activity in plants

Sophie Lanciano et al.

PLOS GENETICS (2017)

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Article Multidisciplinary Sciences

Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines

Pamela Mehanna et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Molecular characterization of cell-free eccDNAs in human plasma

Jing Zhu et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Identification of Extrachromosomal Circular DNA in Hop via Rolling Circle Amplification

Alfredo Diaz-Lara et al.

CYTOGENETIC AND GENOME RESEARCH (2016)

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Article Multidisciplinary Sciences

Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining

Guangqing Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Extrachromosomal circular DNA is common in yeast

Henrik D. Moller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Somatic mutation in single human neurons tracks developmental and transcriptional history

Michael A. Lodato et al.

SCIENCE (2015)

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Article Cell Biology

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

Laura W. Dillon et al.

CELL REPORTS (2015)

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Article Biochemistry & Molecular Biology

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Jakob Loven et al.

CELL (2013)

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Article Biochemistry & Molecular Biology

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte et al.

CELL (2013)

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Article Biochemistry & Molecular Biology

Super-Enhancers in the Control of Cell Identity and Disease

Denes Hnisz et al.

CELL (2013)

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Article Multidisciplinary Sciences

Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues

Yoshiyuki Shibata et al.

SCIENCE (2012)

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Article Biochemistry & Molecular Biology

DNA released from dying host cells mediates aluminum adjuvant activity

Thomas Marichal et al.

NATURE MEDICINE (2011)

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Review Cell Biology

Extrachromosomal Circular DNA in Eukaryotes: Possible Involvement in the Plasticity of Tandem Repeats

S. Cohen et al.

CYTOGENETIC AND GENOME RESEARCH (2009)

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Review Genetics & Heredity

Complex human chromosomal and genomic rearrangements

Feng Zhang et al.

TRENDS IN GENETICS (2009)

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Article Multidisciplinary Sciences

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

ZhiChao Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Biochemistry & Molecular Biology

Evidence for rolling circle replication of tandem genes in Drosophila

S Cohen et al.

NUCLEIC ACIDS RESEARCH (2005)

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Article Biochemistry & Molecular Biology

Involvement of DNase γ in apoptosis associated with myogenic differentiation of C2C12 cells

D Shiokawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Extrachromosomal circular DNA: Current status and future prospects

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