4.6 Article

A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

Shengjun Hong et al.

Summary: This study identified novel genetic associations between TMEM106B and NfL CSF levels, as well as between CPOX and YKL-40. The findings provide important insights into interindividual variation in AD-related CSF biomarkers, shedding light on the sequence of events in neuropathological processes relevant to AD.

ALZHEIMERS & DEMENTIA (2021)

Article Genetics & Heredity

Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology

Eilis Hannon et al.

Summary: This study found significant differences in DNA methylation (DNAm) levels and variability across different peripheral tissues and blood cell types, with DNAm variation in whole blood being additively influenced by a combination of major blood cell types. While most DNAm variation in individual blood cell types weakly predicts variance in DNAm measured in whole blood, for a subset of sites, variable DNAm detected in whole blood can be attributed to a specific blood cell type, potentially providing mechanistic insight about EWAS findings.

PLOS GENETICS (2021)

Article Multidisciplinary Sciences

A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex

Rebecca G. Smith et al.

Summary: Epigenome-wide association studies of Alzheimer's disease have identified DNA methylation differences associated with neuropathology, with 236 CpGs in the prefrontal cortex, 95 CpGs in the temporal gyrus, and ten CpGs in the entorhinal cortex being significant. Cross-cortex meta-analysis revealed 220 CpGs associated with neuropathology, annotated to 121 genes, with 84 genes not previously reported at this significance threshold.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

Kira A. Perzel Mandell et al.

Summary: The study found that DNA methylation is influenced by genetic factors, with a significant portion of genes and regions being associated with SNPs and CpG sites, providing insights into the genetic susceptibility of schizophrenia. By uncovering regions of differential methylation caused by schizophrenia risk-SNPs, the research discusses the relevance of epigenetic plasticity in the brain.

NATURE COMMUNICATIONS (2021)

Article Medicine, General & Internal

Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study

Ilja Demuth et al.

Summary: The GendAge study in Germany focuses on cardiovascular and metabolic diseases, examining risk factors and outcomes in the context of sex and gender differences. Data collected includes a range of medical fields with a focus on cardiometabolic diseases and gender disparities.

BMJ OPEN (2021)

Article Biotechnology & Applied Microbiology

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Marta F. Nabais et al.

Summary: This study identified shared differentially methylated positions in whole blood between neurodegenerative disorders, indicating shared pathogenic mechanisms. Immune abnormalities caused by different neurodegenerative diseases may be interrelated to some extent.

GENOME BIOLOGY (2021)

Article Biochemical Research Methods

Bigmelon: tools for analysing large DNA methylation datasets

Tyler J. Gorrie-Stone et al.

BIOINFORMATICS (2019)

Article Neurosciences

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

Jenny van Dongen et al.

BIOLOGICAL PSYCHIATRY (2019)

Article Biotechnology & Applied Microbiology

A genomic atlas of systemic interindividual epigenetic variation in humans

Chathura J. Gunasekara et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Meta-analysis of epigenome-wide association studies of cognitive abilities

Riccardo E. Marioni et al.

MOLECULAR PSYCHIATRY (2018)

Article Cell Biology

Role of DNA methylation in human age prediction

Neelam Goel et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

Article Biochemical Research Methods

ChAMP: updated methylation analysis pipeline for Illumina BeadChips

Yuan Tian et al.

BIOINFORMATICS (2017)

Meeting Abstract Clinical Neurology

GENOME-WIDE DNA METHYLATION COMPARISON BETWEEN LIVE HUMAN BRAIN AND PERIPHERAL TISSUES WITHIN INDIVIDUALS

Patricia Braun et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2017)

Article Biochemical Research Methods

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies

Andrew E. Teschendorff et al.

BMC BIOINFORMATICS (2017)

Article Biochemical Research Methods

missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform

Belinda Phipson et al.

BIOINFORMATICS (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Correction Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types (vol 14, pg R115, 2013)

Steve Horvath

GENOME BIOLOGY (2015)

Article Genetics & Heredity

DNA Extracted From Saliva for Methylation Studies of Psychiatric Traits: Evidence for Tissue Specificity and Relatedness to Brain

Alicia K. Smith et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2015)

Article Public, Environmental & Occupational Health

Cohort Profile: The Berlin Aging Study II (BASE-II)

Lars Bertram et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Jessica Nordlund et al.

GENOME BIOLOGY (2013)

Article Biochemical Research Methods

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

Andrey A. Shabalin

BIOINFORMATICS (2012)

Article Multidisciplinary Sciences

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

Fran Supek et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Human DNA methylomes at base resolution show widespread epigenomic differences

Ryan Lister et al.

NATURE (2009)

Article Multidisciplinary Sciences

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

Andrew E. Teschendorff et al.

PLOS ONE (2009)

Article Biochemical Research Methods

The effects of pH on DNA methylation state:: In vitro and post-mortem brain studies

Carl Ernst et al.

JOURNAL OF NEUROSCIENCE METHODS (2008)

Article Biochemistry & Molecular Biology

The Schizosaccharomyces pombe mgU6-47 gene is required for 2′-O-methylation of U6 snRNA at A41

H Zhou et al.

NUCLEIC ACIDS RESEARCH (2002)