Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200488
Keywords
cobalt-catalyzed; hydrogen atom transfer; isomerization; O-deallylation; substituted vinyl ethers
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Funding
- National Natural Science Foundation of China [22101109, 22101110]
- Key Scientific Research Projects of Higher Education of Henan Province [22A150015]
- Natural Science Foundation of Henan Province, China [202300410135]
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A simple, mild, and efficient method for the isomerization of 2-substituted allyl ethers has been developed using a cobalt-catalyzed hydrogen atom transfer process. The in-situ oxidized trivalent cobalt complex by tert-butyl hydroperoxide exhibits higher catalytic activity compared to prefabricated cobalt catalysts. This protocol shows excellent chemoselectivity, good functional group tolerance, and high yields.
A simple, mild and efficient method for the isomerization of 2-substituted allyl ethers has been developed by cobalt-catalyzed hydrogen atom transfer (HAT) process. The trivalent cobalt complex oxidized in-situ by tert-butyl hydroperoxide (tBuOOH) exhibits higher catalytic activity than prefabricated trivalent cobalt catalysts. This facile protocol displays excellent chemoselectivity, good functional group tolerance and high yields. The obtained vinyl ethers can be easily hydrolyzed by N-iodosuccinimide/water to afford corresponding phenols or alcohols.
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