Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200437
Keywords
aryl nitriles; cyanation; copper catalysis; coupling; formamide
Categories
Funding
- Provincial Natural Science Foundation of Hunan Province [2022JJ30040]
- National Natural Science Foundation of China [21772168]
- Key Foundation of Education Bureau of Hunan Province [17A208]
Ask authors/readers for more resources
A practical and convenient copper-catalyzed method for cyanation of aryl iodides using formamide as the cyano source has been developed. This method offers high yields of various aryl nitriles, and its lower reaction temperature and excellent substrate compatibility make it more attractive in synthetic and pharmaceutical chemistry.
A practical and convenient protocol for copper-catalyzed cyanation of aryl iodides with formamide as the cyano source was developed, providing various aryl nitriles in good to excellent yields under ligand and base free conditions. Compared to the reported cyanation reactions of aryl halides with formamide at high temperature (130-145 degrees C), lower reaction temperature (100 degrees C) and excellent substrate compatibility make this method more attractive in synthetic and pharmaceutical chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
