4.6 Review

Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis

Related references

Note: Only part of the references are listed.
Article Hematology

Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches

Zhuo Yu et al.

Summary: This study reveals that endothelial cell-derived ANGPTL2 is a critical component of the bone marrow niche that maintains HSC stemness. Through enhancing PPARD expression, ANGPTL2 can transactivate G0s2 and sustain the perinuclear localization of nucleolin, preventing HSCs from entering the cell cycle.

BLOOD (2022)

Article Gastroenterology & Hepatology

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Marcos F. Fondevila et al.

Summary: We found that the expression of CPT1A is elevated in HSCs of patients with fibrosis, and that CPT1A induces the activation of these cells. Inhibition of CPT1A can ameliorate fibrosis by preventing the activation of HSCs.

JOURNAL OF HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis

Jie Qing et al.

Summary: DRD2 antagonism selectively targets YAP-dependent fibrogenic crosstalk between macrophages and CTGF(+)VCAM1(+) vascular niche, promoting liver regeneration over fibrosis in both rodent and large animal models.

JOURNAL OF HEPATOLOGY (2022)

Article Endocrinology & Metabolism

Angiocrine polyamine production regulates adiposity

Erika Monelli et al.

Summary: Reciprocal interactions between endothelial cells and adipocytes play a crucial role in maintaining the homeostasis of adipose tissue. The production of polyamines in endothelial cells stimulates adipocyte lipolysis and regulates adipose tissue homeostasis.

NATURE METABOLISM (2022)

Article Gastroenterology & Hepatology

Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling

Manuel Winkler et al.

Summary: The study reveals that endothelial GATA4 plays a protective role against perisinusoidal liver fibrosis by repressing MYC activation and profibrotic angiocrine signaling. Therapies targeting the GATA4/MYC/PDGFB/PDGFRb axis offer a promising strategy for prevention and treatment of liver fibrosis.

JOURNAL OF HEPATOLOGY (2021)

Article Cell Biology

Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis

Yutian Chen et al.

Summary: Aging impairs regenerative capacity and leads to fibrosis in organs. Aberrant reprogramming of hematopoietic and vascular cell crosstalk in aging hinders regeneration and promotes fibrosis. Targeting aberrant endothelial node molecules may facilitate regeneration without scarring in the repair of multiple organs.

CELL METABOLISM (2021)

Article Multidisciplinary Sciences

In situ mapping identifies distinct vascular niches for myelopoiesis

Jizhou Zhang et al.

Summary: This study develops imaging approaches for myelopoiesis in mice and generates atlases showing the differentiation of granulocytes, monocytes, and dendritic cells in the bone marrow. It reveals that local cues from distinct blood vessels are responsible for the spatial organization of definitive blood cell differentiation.

NATURE (2021)

Article Multidisciplinary Sciences

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

William Roman et al.

Summary: The study revealed that localized muscle injuries triggered by exercise activate a myofiber self-repair mechanism that is independent of satellite cells. A signaling cascade involving calcium, Cdc42, and phosphokinase C attracts myonuclei to the damaged site, accelerating sarcomere repair and delivering messenger RNA for cellular reconstruction. Myofiber self-repair is a cell-autonomous protective mechanism, offering an alternative model for understanding muscle architecture restoration in health and disease.

SCIENCE (2021)

Article Cell Biology

Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis

Hua Zhang et al.

Summary: The study revealed that epigenetically reprogrammed vascular adaptation contributes to liver fibrosis by enriching fibrogenic T(H)17 cells in the liver in NASH patients and animal models. Targeting HDAC2 and DNMT1 with pharmacological agents alleviated fibrosis in a minipig NASH model.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities

Ya-Ming Meng et al.

Summary: The interaction between pericytes and endothelial cells in tumor vasculature plays a crucial role in tumorigenesis and therapy efficacy. High levels of glycolysis driven by hexokinase 2 in tumor pericytes activate contractility, leading to impaired blood vessel supporting function. Inhibition of HK2 in pericytes results in tumor vasculature remodeling and enhanced drug delivery against tumor growth.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Junyu Chen et al.

Summary: Blood vessels play a crucial role in supporting tissue functions, but age-associated vascular changes and their connection to tissue aging remains poorly understood. Vessel density and pericyte numbers decline with age in multiple organs, except highly remodeling tissues like the skin which preserve their vasculature. Molecular changes in the endothelium drive vascular loss and influence pericyte to fibroblast differentiation.

SCIENCE ADVANCES (2021)

Article Gastroenterology & Hepatology

Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C-C Motif Chemokine Ligand 2-Mediated Angiocrine Signaling

Jinhang Gao et al.

Summary: Deletion of endothelial p300 can alleviate portal hypertension and liver fibrosis caused by liver injury, reducing macrophage accumulation. The regulation of inflammation may be associated with Ccl2, NF kappa B, and BRD4.

HEPATOLOGY (2021)

Article Multidisciplinary Sciences

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

Yanpu Chen et al.

Summary: Research shows that expression of OSKM genes in adult cardiomyocytes can induce these cells to dedifferentiate, conferring regenerative capacity to the heart. This short-term dedifferentiation and reprogramming can ameliorate myocardial damage and facilitate heart regeneration.

SCIENCE (2021)

Article Multidisciplinary Sciences

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Yue Xi et al.

Summary: The study demonstrates that GLRX reverses PSSG by liberating GSH, inhibiting activation of hepatic stellate cells and liver fibrosis. GLRX depletion exacerbates liver fibrosis, while overexpression of GLRX inhibits PSSG and liver fibrosis development.

SCIENCE ADVANCES (2021)

Article Multidisciplinary Sciences

Decoding myofibroblast origins in human kidney fibrosis

Christoph Kuppe et al.

Summary: Using single-cell RNA sequencing, researchers profiled the transcriptomes of healthy and fibrotic human kidneys, identifying distinct subpopulations of pericytes and fibroblasts as the main sources of scar-forming myofibroblasts during kidney fibrosis. This study shed light on the cellular origins and differentiation of myofibroblasts in human kidney fibrosis, identifying potential therapeutic targets such as NKD2.

NATURE (2021)

Review Biotechnology & Applied Microbiology

Targeting metabolic dysregulation for fibrosis therapy

Xiao Zhao et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

Brisa Palikuqi et al.

NATURE (2020)

Article Gastroenterology & Hepatology

Tracking Fenestrae Dynamics in Live Murine Liver Sinusoidal Endothelial Cells

Bartlomiej Zapotoczny et al.

HEPATOLOGY (2019)

Review Biochemistry & Molecular Biology

VEGF in Signaling and Disease: Beyond Discovery and Development

Rajendra S. Apte et al.

Article Multidisciplinary Sciences

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Giovanni Giuseppe Giobbe et al.

NATURE COMMUNICATIONS (2019)

Review Cell & Tissue Engineering

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Kacey Ronaldson-Bouchard et al.

CELL STEM CELL (2018)

Article Gastroenterology & Hepatology

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Thomas Leibing et al.

HEPATOLOGY (2018)

Article Biotechnology & Applied Microbiology

An in vivo model of functional and vascularized human brain organoids

Abed AlFatah Mansour et al.

NATURE BIOTECHNOLOGY (2018)

Review Physiology

ENDOTHELIAL CELL METABOLISM

Guy Eelen et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Immunology

Macrophages in the Aging Liver and Age-Related Liver Disease

Elizabeth C. Stahl et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Biotechnology & Applied Microbiology

Whole Organ Tissue Vascularization: Engineering the Tree to Develop the Fruits

Alessandro F. Pellegata et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

Article Hematology

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

Philipp-Sebastian Koch et al.

BLOOD (2017)

Article Immunology

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

Kimberly Martinod et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Gastroenterology & Hepatology

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

Johanne Poisson et al.

JOURNAL OF HEPATOLOGY (2017)

Review Biochemical Research Methods

In vivo imaging of neural activity

Weijian Yang et al.

NATURE METHODS (2017)

Review Pharmacology & Pharmacy

Pericytes, an overlooked player in vascular pathobiology

David Ferland-McCollough et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Review Multidisciplinary Sciences

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

Hellmut G. Augustin et al.

SCIENCE (2017)

Article Cell Biology

Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

Zhongwei Cao et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Platelets prime hematopoietic-vascular niche to drive angiocrine-mediated liver regeneration

Koji Shido et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Review Cell Biology

Lymphangiogenesis: Origin, Specification, and Cell Fate Determination

Noelia Escobedo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)

Review Multidisciplinary Sciences

Angiocrine functions of organ-specific endothelial cells

Shahin Rafii et al.

NATURE (2016)

Article Multidisciplinary Sciences

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Kerstin Wilhelm et al.

NATURE (2016)

Article Multidisciplinary Sciences

Age-dependent modulation of vascular niches for haematopoietic stem cells

Anjali P. Kusumbe et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

Jong-Seok Moon et al.

NATURE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

Zhongwei Cao et al.

NATURE MEDICINE (2016)

Review Biochemistry & Molecular Biology

Establishment and Dysfunction of the Blood-Brain Barrier

Zhen Zhao et al.

Article Multidisciplinary Sciences

Parent stem cells can serve as niches for their daughter cells

Ana Pardo-Saganta et al.

NATURE (2015)

Article Multidisciplinary Sciences

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Andrew E. Vaughan et al.

NATURE (2015)

Article Gastroenterology & Hepatology

Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo

Teagan J. Walter et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Review Medicine, Research & Experimental

Fibrosis: ultimate and proximate causes

Victor J. Thannickal et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Medicine, Research & Experimental

Canonical WNT signaling components in vascular development and barrier formation

Yulian Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

Alveolar progenitor and stem cells in lung development, renewal and cancer

Tushar J. Desai et al.

NATURE (2014)

Article Multidisciplinary Sciences

Mfsd2a is critical for the formation and function of the blood-brain barrier

Ayal Ben-Zvi et al.

NATURE (2014)

Article Multidisciplinary Sciences

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Long N. Nguyen et al.

NATURE (2014)

Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

Review Biochemistry & Molecular Biology

Lung regeneration: mechanisms, applications and emerging stem cell populations

Darrell N. Kotton et al.

NATURE MEDICINE (2014)

Article Multidisciplinary Sciences

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

Lida Katsimpardi et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

Manisha Sinha et al.

SCIENCE (2014)

Review Cell Biology

Wound repair and regeneration: Mechanisms, signaling, and translation

Sabine A. Eming et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Cell Biology

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

Louise Hecker et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Medicine, Research & Experimental

Type 2 alveolar cells are stem cells in adult lung

Christina E. Barkauskas et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Review Biochemistry & Molecular Biology

Development, maintenance and disruption of the blood-brain barrier

Birgit Obermeier et al.

NATURE MEDICINE (2013)

Editorial Material Respiratory System

Progress in modelling acute lung injury in a pre-clinical mouse model

Michael A. Matthay et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Review Medicine, Research & Experimental

Building and maintaining the epithelium of the lung

Craig R. Rackley et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Cell Biology

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

Eduard Hergenreider et al.

NATURE CELL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Thomas A. Wynn et al.

NATURE MEDICINE (2012)

Review Biochemistry & Molecular Biology

Basic and Therapeutic Aspects of Angiogenesis

Michael Potente et al.

Article Developmental Biology

Signal transduction in vasculogenesis and developmental angiogenesis

Sunita Patel-Hett et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2011)

Article Medicine, Research & Experimental

The three R's of lung health and disease: repair, remodeling, and regeneration

Michael F. Beers et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Multidisciplinary Sciences

Molecular mechanisms and clinical applications of angiogenesis

Peter Carmeliet et al.

NATURE (2011)

Review Cell Biology

Organogenesis and Development of the Liver

Karim Si-Tayeb et al.

DEVELOPMENTAL CELL (2010)

Article Medicine, Research & Experimental

VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats

Laszlo Farkas et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Peripheral Vascular Disease

Vascular permeability, vascular hyperpermeability and angiogenesis

Janice A. Nagy et al.

ANGIOGENESIS (2008)

Article Medicine, Research & Experimental

The FGF system has a key role in regulating vascular integrity

Masahiro Murakami et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Multidisciplinary Sciences

Generation and Regeneration of Cells of the Liver and Pancreas

Kenneth S. Zaret et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Elisabeth M. Zeisberg et al.

NATURE MEDICINE (2007)

Article Biotechnology & Applied Microbiology

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Zack Z. Wang et al.

NATURE BIOTECHNOLOGY (2007)

Review Cardiac & Cardiovascular Systems

Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms

William C. Aird

CIRCULATION RESEARCH (2007)

Review Cardiac & Cardiovascular Systems

Phenotypic heterogeneity of the endothelium II. Representative vascular beds

William C. Aird

CIRCULATION RESEARCH (2007)

Article Cardiac & Cardiovascular Systems

Hyperlipidemia and surfactants: The liver sieve is a link

Victoria C. Cogger et al.

ATHEROSCLEROSIS (2006)

Review Hematology

Mechanisms of endothelial differentiation in embryonic vasculogenesis

JE Ferguson et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

I Petrache et al.

NATURE MEDICINE (2005)