Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 11, Issue 11, Pages 1135-1142Publisher
OXFORD UNIV PRESS
DOI: 10.1093/stcltm/szac070
Keywords
angiocrine; endothelial cells; regeneration; fibrosis; vascular
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Funding
- China Postdoctoral Science Foundation [2022TQ0299]
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Blood vessels play a crucial role in various physiological processes and can actively participate by releasing growth factors. Understanding the vascular niche and factors maintaining vascular homeostasis is important for clinical treatment.
The vasculature occupies a large area of the body, and none of the physiological activities can be carried out without blood vessels. Blood vessels are not just passive conduits and barriers for delivering blood and nutrients. Meanwhile, endothelial cells covering the vascular lumen establish vascular niches by deploying some growth factors, known as angiocrine factors, and actively participate in the regulation of a variety of physiological processes, such as organ regeneration and fibrosis and the occurrence and development of cancer. After organ injury, vascular endothelial cells regulate the repair process by secreting various angiocrine factors, triggering the proliferation and differentiation process of stem cells. Therefore, analyzing the vascular niche and exploring the factors that maintain vascular homeostasis can provide strong theoretical support for clinical treatment targeting blood vessels. Here we mainly discuss the regulatory mechanisms of the vascular niche in organ regeneration and fibrosis.
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