Journal
PRIMARY CARE DIABETES
Volume 16, Issue 6, Pages 824-828Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pcd.2022.09.003
Keywords
Mortality; Diabetes mellitus; type 2; Body composition
Categories
Funding
- National Key Research and Development Program of China [2019YFA0802502]
- National Natural Science Foundation of China [81830025, 81620108004]
- Tianjin Municipal Science and Technology Commission [19JCQNJC11800]
- Tianjin Research Innovation Project for Postgraduate Students [2019YJSB107]
- Tianjin Medical University Postgraduate Innovation Fund of 13th Five-Year Comprehensive Investment [YJSCX201904]
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The distribution of lean mass is associated with the risk of all-cause mortality in patients with type 2 diabetes. A higher android-to-gynoid lean mass ratio is significantly associated with increased risk of all-cause mortality.
Aims: The aim of the study is to evaluate the association of distribution of lean mass with the risk of all-cause mortality among patients with type 2 diabetes. Methods: The present cohort study included 2 335 patients with type 2 diabetes. Lean mass was assessed by dual energy X-ray absorptiometry. Cox proportional hazards regressions were used to estimate the association of lean mass distribution on the risk of mortality. Results: The average age of the patients was 58 years at baseline and 51.4% of patients were women. During a median follow-up of 4.31 years, 128 patients died. The multivariable-adjusted hazards ratios for all-cause mortality were 1.00, 1.63 (0.89-2.99), and 2.68(1.51-4.76) across the tertiles of android-to-gynoid lean mass ratio (P for trend < 0.001), respectively. The positive association of android-to-gynoid lean mass ratio with the risk of all-cause mortality was present among patients of different ages, body mass index >= 24 kg/m2, hemo-globin A1c >= 7.0%, nonsmokers, men, patients using insulin, and patients with diabetes durations of more than 10 years. Conclusions: Higher android-to-gynoid lean mass ratio, assessed by dual energy X-ray absorptiometry, was significantly associated with increased risk of all-cause mortality among patients with type 2 diabetes.
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