4.7 Article

Stimulus-Responsive, Gelatin-Containing Supramolecular Nanofibers as Switchable 3D Microenvironments for Cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Reciprocal cell-ECM dynamics generate supracellular fluidity underlying spontaneous follicle patterning

Karl H. Palmquist et al.

Summary: During vertebrate embryogenesis, cell collectives engage in coordinated behavior to form tissue structures of increasing complexity. The initiation of follicle patterning in avian skin is initiated by the mechanical rearrangement of extracellular matrix (ECM) by contractile cells, which further aligns the cells and transforms them into a continuum with coherent, long-range order. This ordered cell-ECM layer behaves as an active contractile fluid and spontaneously forms regular patterns, illustrating the role of mesenchymal dynamics in generating cell-level ordering and tissue-level patterning.
Review Pharmacology & Pharmacy

Ocular Barriers and Their Influence on Gene Therapy Products Delivery

Bastien Leclercq et al.

Summary: The eye is composed of tissues and cavities that are regulated to maintain their optical properties and functions. Specialized junctions between cells control the passage of drugs, while specific transporters regulate the movement of water, ions, and macromolecules. Ocular barriers limit the bioavailability of gene therapy products, but also allow for local treatment with minimal systemic side-effects. Understanding these barriers is essential for the development of efficient gene delivery systems.

PHARMACEUTICS (2022)

Article Materials Science, Multidisciplinary

One-Step Synthesis of Gelatin-Conjugated Supramolecular Hydrogels for Dynamic Regulation of Adhesion Contact and Morphology of Myoblasts

Kentaro Hayashi et al.

Summary: This study developed a hydrogel with fine-adjustable and switchable elasticity to mimic the mechanical microenvironments of biological cells. It enables the direct and reversible mechanical stimulation of cells without the need for tedious surface functionalization with adhesion ligands.

ACS APPLIED POLYMER MATERIALS (2022)

Article Biochemistry & Molecular Biology

Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels

Benbo Zhao et al.

Summary: This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels, which showed improved mechanical properties, anti-degradation properties, and reduced swelling properties. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels without changing their stability and crosslinking network structure. These hydrogels have potential applications in tissue engineering scaffolds.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

Jason S. Silver et al.

Summary: Elevated muscle stiffness enhances migration and proliferation of MuSCs by localizing YAP and TAZ to the nucleus. Ablating YAP and TAZ induces MuSC quiescence after injury and prevents myofiber hypertrophy.

SCIENCE ADVANCES (2021)

Review Engineering, Biomedical

Tissue-specific parameters for the design of ECM-mimetic biomaterials

Olivia R. Tonti et al.

Summary: The extracellular matrix (ECM) is crucial for directing cell behavior and maintaining tissue function. While advancements in technology allow for better in vitro modeling of tissue properties, tissue-specific variations in ECM composition are often overlooked. This review highlights the importance of considering the complexity of ECM in different tissues to better emulate human pathologies in in vitro models.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

Recent Progress in Cartilage Lubrication

Weifeng Lin et al.

Summary: Healthy articular cartilage has very low friction coefficients, which help reduce wear and tear and cartilage degradation, maintaining the balance of chondrocyte functions. Investigating the origins of low friction in articular cartilage is crucial for alleviating disease symptoms and slowing or reversing the degradation process. Recent studies have focused on the mechanisms of joint lubrication and the development of natural and bio-inspired lubricants.

ADVANCED MATERIALS (2021)

Review Polymer Science

Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine-A Review

Andrea Ehrmann

Summary: Electrospinning is a versatile method for preparing nanofiber mats from various polymers, including biopolymers, which have important applications in biotechnology and biomedicine. Some biopolymers are water-soluble and require crosslinking after electrospinning. This study focuses on non-toxic or low-toxic crosslinking methods, as well as blending gelatin with non-water soluble polymers to produce water-insoluble nanofibers.

POLYMERS (2021)

Review Chemistry, Multidisciplinary

Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers

Jiajia Xue et al.

ADVANCED SCIENCE (2020)

Article Multidisciplinary Sciences

Mechanical stimulation of single cells by reversible host-guest interactions in 3D microscaffolds

Marc Hippler et al.

SCIENCE ADVANCES (2020)

Article Chemistry, Multidisciplinary

Supramolecular self-healing materials from non-covalent cross-linking host-guest interactions

Garry Sinawang et al.

CHEMICAL COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

William Y. Wang et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Controlling the shape of 3D microstructures by temperature and light

Marc Hippler et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

New Class of Crosslinker-Free Nanofiber Biomaterials from Hydra Nematocyst Proteins

Theresa Bentele et al.

SCIENTIFIC REPORTS (2019)

Review Biochemistry & Molecular Biology

Matrix metalloproteinases in emphysema

Sina A. Gharib et al.

MATRIX BIOLOGY (2018)

Article Cell & Tissue Engineering

Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

Leqian Yu et al.

STEM CELL REPORTS (2018)

Article Materials Science, Biomaterials

Silk nanofiber hydrogels with tunable modulus to regulate nerve stem cell fate

ShuMeng Bai et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

Article Biotechnology & Applied Microbiology

Cell adhesion and proliferation enhancement by gelatin nanofiber scaffolds

Shih-Ching Wu et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2011)

Article Chemistry, Multidisciplinary

Quantitative Evaluation of Mechanosensing of Cells on Dynamically Tunable Hydrogels

Hiroshi Y. Yoshikawa et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Microscopy

Collagen type I amide I band infrared spectroscopy

Benedicto de Campos Vidal et al.

MICRON (2011)

Article Chemistry, Multidisciplinary

Macroscopic self-assembly through molecular recognition

Akira Harada et al.

NATURE CHEMISTRY (2011)

Article Physics, Applied

Chemical functionalization of GaN and AlN surfaces

B Baur et al.

APPLIED PHYSICS LETTERS (2005)

Article Engineering, Biomedical

Cross-linking and characterisation of gelatin matrices for biomedical applications

AJ Kuijpers et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2000)