The Fabrication of Alginate-Carboxymethyl Cellulose-Based Composites and Drug Release Profiles

Recently, hydrogels based on natural water-soluble polysaccharides have attracted more and more attention due to their favorable characteristics. The high water-holding capacity, lack of toxicity, and biodegradability of such hydrogels make it possible to develop new materials on their basis for biotechnological, biomedical, pharmacological, and medical purposes. Sodium alginate is a non-toxic natural polysaccharide found in marine algae. It is capable of forming solid gels under the action of polyvalent cations that cross-link polysaccharide chains. Alginate-based products are popular in many industries, including food processing, pharmaceutical, and biomedical applications. Cellulose is the most abundant, renewable, and natural polymer on Earth, and it is used for various industrial and biomedical applications. Carboxymethyl cellulose (CMC) is useful in pharmaceutical, food, and non-food industries such as tablets, ice cream, drinks, toothpaste, and detergents. In this review, various methods for the preparation of the compositions based on sodium alginate and CMC using different crosslinking agents have been collected for the first time. Additionally, the drug release profile from such polymer matrixes was analyzed.

Automated summary

Hydrogels based on natural water-soluble polysaccharides have gained attention for their favorable characteristics, including high water-holding capacity, lack of toxicity, and biodegradability. Sodium alginate and cellulose are commonly used polysaccharides in various industries, such as food processing, pharmaceuticals, and biomedical applications. This review collects various methods for preparing compositions using sodium alginate and cellulose, and analyzes the drug release profile from these polymer matrices.