Journal
POLYMERS
Volume 14, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/polym14183712
Keywords
dentin-pulp complex regeneration; signalling molecules; stem cell from human exfoliated deciduous teeth (SHED); tissue engineering
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Funding
- Faculty of Dentistry, Maranatha Christian University
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Maintaining dental pulp vitality and preventing tooth loss are challenges in endodontic treatment. Tissue engineering, especially using stem cells, has emerged as a potential alternative therapy for regenerating dental tissues.
Maintaining dental pulp vitality and preventing tooth loss are two challenges in endodontic treatment. A tooth lacking a viable pulp loses its defense mechanism and regenerative ability, making it more vulnerable to severe damage and eventually necessitating extraction. The tissue engineering approach has drawn attention as an alternative therapy as it can regenerate dentin-pulp complex structures and functions. Stem cells or progenitor cells, extracellular matrix, and signaling molecules are triad components of this approach. Stem cells from human exfoliated deciduous teeth (SHED) are a promising, noninvasive source of stem cells for tissue regeneration. Not only can SHEDs regenerate dentin-pulp tissues (comprised of fibroblasts, odontoblasts, endothelial cells, and nerve cells), but SHEDs also possess immunomodulatory and immunosuppressive properties. The collagen matrix is a material of choice to provide structural and microenvironmental support for SHED-to-dentin pulp tissue differentiation. Growth factors regulate cell proliferation, migration, and differentiation into specific phenotypes via signal-transduction pathways. This review provides current concepts and applications of the tissue engineering approach, especially SHEDs, in endodontic treatment.
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