Journal
PLOS NEGLECTED TROPICAL DISEASES
Volume 16, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0010815
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Funding
- Bill and Melinda Gates Foundation [OPP1066146, OPP1152146]
- National Institutes of Health of the United States [R01AI158576, R21AI163801, D43TW010913]
- USDA-ARS CRIS project [2030-42000-055-00D]
- Bill and Melinda Gates Foundation [OPP1066146, OPP1152146] Funding Source: Bill and Melinda Gates Foundation
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Campylobacter spp. are a major cause of bacterial diarrhea worldwide. This study used WSMS to identify multiple Campylobacter species in stool samples from children in a Peruvian community, and found co-infections with multiple Campylobacter species, which is a novel finding.
Campylobacter spp. are a major cause of bacterial diarrhea worldwide and are associated with high rates of mortality and linear growth faltering in children living in low- to middle-income countries (LMICs). Campylobacter jejuni and Campylobacter coli are most often the causative agents of enteric disease among children in LMICs. However, previous work on a collection of stool samples from children under 2 years of age, living in a low resource community in Peru with either acute diarrheal disease or asymptomatic, were found to be qPCR positive for Campylobacter species but qPCR negative for C. jejuni and C. coli. The goal of this study was to determine if whole-genome shotgun metagenomic sequencing (WSMS) could identify the Campylobacter species within these samples. The Campylobacter species identified in these stool samples included C. jejuni, C. coli, C. upsaliensis, C. concisus, and the potential new species of Campylobacter, Candidatus Campylobacter infans. Moreover, WSMS results demonstrate that over 65% of the samples represented co-infections with multiple Campylobacter species present in a single stool sample, a novel finding in human populations.
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