Journal
PEDIATRIC OBESITY
Volume 18, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/ijpo.12976
Keywords
child growth; fetal growth; glucose; growth trajectories; insulin
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This study aimed to examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Data from the ROLO study were analyzed, and no strong evidence of associations between maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories was found.
Objective To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Methods Data from mother-child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed. Fetal and child growth trajectories were developed from longitudinal measurements from 20 weeks gestation up to 5 years of age. We examined associations between maternal fasting glucose, insulin, HOMA-IR and leptin, taken in early pregnancy (14-16 weeks) and late pregnancy (28 weeks), and weight (kg) and abdominal circumference (cm) trajectories using linear spline multilevel models. Results We found no strong evidence of associations between any maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories from 20 weeks gestation to 5 years. Conclusion In a cohort of women with obesity with infants at risk of macrosomia, maternal metabolic markers were not strongly associated with trajectories of weight or abdominal circumference from 20 weeks gestation to 5 years of age.
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