Emerging roles of centrosome cohesion

The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells. During niu4 of interphase, the two centrosomes of a cell are joined together by centrosome cohesion into one MTOC. The most dominant element of centrosome cohesion is the centrosome linker, an interdigitatimg, fibrous network formed by the }Protein C-Nap1 anchoring a number of coiled-coil proteins including rootletin to the proximal end of centrioles. Alternatively, centrosomes can be kept together by the action of the minus encl. directed kinesin motor protein KIFC3 that works on inturdigitating microtubules organised by both centrosomes and probably by the actin network. Although cells connect the two interphase centrosomes by several mechanisms into one MTOC, the general importance of centrosome cohesion, particularly for an organism, is still largely unclear. In this article, ter review the functions; of the centrosome linker and discuss how centrosome cohesion defects can lead to diseases.

Automated summary

This article reviews the functions of the centrosome linker and discusses how centrosome cohesion defects can lead to diseases.