4.7 Article

Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Journal

NANO-MICRO LETTERS
Volume 14, Issue 1, Pages -

Publisher

SHANGHAI JIAO TONG UNIV PRESS
DOI: 10.1007/s40820-022-00928-z

Keywords

Bioinspired injectable hydrogel; Tissue sealant; Temperature-dependent adhesion; Reversible adhesion; Wound healing

Funding

  1. National Natural Science Foundation of China [51973172]
  2. Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
  3. State Key Laboratory for Mechanical Behavior of Materials
  4. World-Class Universities (Disciplines) and Characteristic Development Guidance Funds for the Central Universities
  5. Fundamental Research Funds for the Central Universities
  6. Opening Project of the Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2019LHM-KFKT008]

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This article introduces a multifunctional hydrogel adhesive prepared by a bioinspired dynamic bond cross-linking method, which can be used for seamless wound closure and wound healing. The hydrogel has sufficient mechanical and adhesive strength, as well as injectability and self-healing capacity, which can effectively close wounds and repeatedly close reopened wounds. In addition, it also has good biocompatibility, antibacterial activity, and hemostatic effect.
Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant and repeated tissue adhesion, are urgently demanded for invasive wound closure and wound healing. Motivated by the adhesive mechanism of mussel and brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel adhesive is designed based on sodium alginate (SA), gelatin (GT) and protocatechualdehyde, with ferric ions added, for sutureless post-wound-closure. The dynamic hydrogel cross-linked through Schiff base bond, catechol-Fe coordinate bond and the strong interaction between GT with temperature-dependent phase transition and SA, endows the resulting hydrogel with sufficient mechanical and adhesive strength for efficient wound closure, injectability and self-healing capacity, and repeated closure of reopened wounds. Moreover, the temperature-dependent adhesive properties endowed mispositioning hydrogel to be removed/repositioned, which is conducive for the fault-tolerant adhesion of the hydrogel adhesives during surgery. Besides, the hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation and repeated thermo-responsive reversible adhesion and good hemostatic effect. The in vivo incision closure evaluation demonstrated their capability to promote the post-wound-closure and wound healing of the incisions, indicating that the developed reversible adhesive hydrogel dressing could serve as versatile tissue sealant.

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