In silico investigation of Panax ginseng lead compounds against COVID-19 associated platelet activation and thromboembolism

Review Plant Sciences

Panax ginseng: Inflammation, platelet aggregation, thrombus formation, and atherosclerosis crosstalk

Yuan Yee Lee et al.

Summary: This article summarizes the therapeutic effects of ginseng on cardiovascular diseases, focusing on its influence on platelet aggregation, plaque formation, and thrombus formation.

JOURNAL OF GINSENG RESEARCH (2022)

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Article Plant Sciences

Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts

Muhammad Irfan et al.

Summary: This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG) and found that both extracts can inhibit platelet aggregation and calcium mobilization, indicating their potential for maintaining cardiovascular health and preventing platelet-related cardiovascular disorders.

JOURNAL OF GINSENG RESEARCH (2022)

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Article Medicine, Research & Experimental

Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein

Tianyang Li et al.

Summary: Infection with SARS-CoV-2 can lead to COVID-19, which ranges from mild to moderate disease but carries the risk of morbidity and mortality. Severe cases of COVID-19 are associated with hemostasis disorders, monocyte activation, and a cytokine storm, but the connection between these manifestations is not fully understood. This study reveals that the spike protein of SARS-CoV-2 interacts with P-selectin/PGSL-1 and CD40L/CD40, leading to proinflammatory cytokine production by monocytes. These findings provide an explanation for the correlation between hypercoagulation, monocyte activation, and a cytokine storm in severely affected COVID-19 patients, and suggest a potential target for therapeutic intervention.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Hematology

Interplay between platelets and coagulation

Yaqiu Sang et al.

Summary: Haemostasis is a regulated physiological process involving interactions between endothelial cells, platelets, von Willebrand factor, and coagulation factors. Platelets and coagulation mutually influence each other to effectively stop bleeding by forming a platelet plug.

BLOOD REVIEWS (2021)

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Review Infectious Diseases

Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence

Hui Xian Jaime Lin et al.

Summary: Remdesivir has shown potential as a therapeutic agent against COVID-19, with evidence demonstrating its ability to shorten time to recovery and hospital stay for patients. However, further large-scale clinical trials are needed to validate these findings.

INFECTION (2021)

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Review Medicine, General & Internal

COVID-19 coagulopathy: is it disseminated intravascular coagulation?

Marcel Levi et al.

Summary: Severe COVID-19 infections can lead to coagulopathy related to both venous and arterial thromboembolic disease, with characteristics that are similar but not identical to DIC. The virus's direct infection and damage to endothelial cells affect the coagulation response to COVID-19, potentially requiring separate diagnostic criteria for this distinct intravascular coagulation syndrome.

INTERNAL AND EMERGENCY MEDICINE (2021)

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Letter Hematology

Platelets are Hyperactivated but Show Reduced Glycoprotein VI Reactivity in COVID-19 Patients

Valentine Leopold et al.

THROMBOSIS AND HAEMOSTASIS (2021)

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Article Integrative & Complementary Medicine

Anti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy

Zhi-yi Xu et al.

Summary: This study demonstrated that Panax notoginseng triol saponins (PTS) showed a stronger anti-platelet aggregation effect compared to Panax notoginseng total saponins (PNS) in a rat model of middle cerebral artery occlusion (MCAO). The combination of PTS and aspirin could reduce adverse gastrointestinal effects by regulating the TXA(2)/PGI(2) ratio. PTS was also shown to regulate Glycoprotein Ib-alpha (GP1BA) and reduce von Willebrand factor (VWF)-mediated platelet adhesion, providing new evidence for its clinical application in ischemic stroke therapy.

CHINESE MEDICINE (2021)

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Article Hematology

Platelet-activating immune complexes identified in critically ill COVID-19 patients suspected of heparin-induced thrombocytopenia

Ishac Nazy et al.

Summary: Our study excludes heparin-induced thrombocytopenia in critically ill COVID-19 patients and identifies platelet-activating immune complexes as a novel mechanism contributing to the disease.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Virology

Platelet-derived sCD40L: specific inflammatory marker for early-stage severe acute respiratory syndrome coronavirus 2 infection

Hind Hamzeh-Cognasse et al.

Summary: The study identified that plasma levels of platelet soluble (s)CD40L are elevated in the early stages of COVID-19, then decrease over time while sCD62P levels increase significantly. These platelet markers could serve as monitoring biomarkers of patient inflammatory state during the disease course.

VIROLOGY JOURNAL (2021)

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Article Biochemistry & Molecular Biology

COVID-19 induces a hyperactive phenotype in circulating platelets

Shane P. Comer et al.

Summary: This study found distinct differences in routine full blood count and other clinical laboratory parameters between patients with severe and nonsevere COVID-19. It also determined that all COVID-19 patients possess hyperactive circulating platelets, suggesting abnormal platelet reactivity may contribute to hypercoagulability in COVID-19, influencing the severity of the disease and recovery path complexity.

PLOS BIOLOGY (2021)

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Letter Gastroenterology & Hepatology

Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19

Barbara Kaltschmidt et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review

Chiara Agrati et al.

Summary: Severe COVID-19 cases present with blood clots and neutrophil-platelet aggregates, leading to an increased risk of cardiovascular complications and venous thrombotic events. The inflammatory storm may disrupt the interplay between platelets, endothelium, and leukocytes, contributing to COVID-19-associated coagulopathy. P-selectin is identified as a key molecule in this process and could potentially be used as a severity marker and therapeutic target for COVID-19 treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control study

Emre Karsli et al.

Summary: This study demonstrates that sP-Selectin can serve as a valuable biomarker for diagnosing and predicting the need for intensive care treatment in COVID-19 infections.

LIFE SCIENCES (2021)

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Article Critical Care Medicine

Platelet activation in critically ill COVID-19 patients

Nader Yatim et al.

Summary: This study found that elevated soluble P-selectin levels at admission were associated with COVID-19 severity and could predict intubation and death. Gene expression analysis indicated that critically ill patients had increased expression of genes related to platelet activation, with specific genes showing grade-dependent upregulation. ROC curve analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation.

ANNALS OF INTENSIVE CARE (2021)

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Article Multidisciplinary Sciences

Platelets amplify endotheliopathy in COVID-19

Tessa J. Barrett et al.

Summary: The study reveals an inflammatory hypercoagulable state between platelets and endothelial cells in COVID-19, with platelet-released factors promoting endotheliopathy. S100A8, S100A9, and their protein product MRP8/14 are enriched in COVID-19 platelets and contribute significantly to poor clinical outcomes. Targeting platelet P2Y(12) appears to be a promising strategy for reducing proinflammatory platelet-endothelial interactions in COVID-19.

SCIENCE ADVANCES (2021)

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Article Plant Sciences

Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation

Jung-Hae Shin et al.

Summary: The study showed that G-Rk1 has an inhibitory effect on human platelet aggregation, particularly more effective on collagen-stimulated platelet aggregation. It can also suppress the activity of various platelet signaling molecules, thus blocking platelet formation of thrombosis.

JOURNAL OF GINSENG RESEARCH (2021)

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Review Hematology

COVID-19-associated coagulopathy and disseminated intravascular coagulation

Hidesaku Asakura et al.

Summary: The pathology of COVID-19 is exacerbated by thrombosis, DIC, and cytokine storms. D-dimer levels are commonly elevated in COVID-19, but relying solely on this marker has limitations. Treatment should be individualized based on disease severity and stage, with potential for combination therapy using heparin and nafamostat in the future. Further research is needed on fibrinolytic therapy and adsorption therapy.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Review Plant Sciences

Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases

Muhammad Irfan et al.

JOURNAL OF GINSENG RESEARCH (2020)

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Review Hematology

Mechanism of thrombocytopenia in COVID-19 patients

Panyang Xu et al.

ANNALS OF HEMATOLOGY (2020)

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Article Cell Biology

Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19)

Francesca Salamanna et al.

PLATELETS (2020)

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Letter Hematology

What do monitoring platelet counts in COVID-19 teach us?

Jecko Thachil

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis

Mauro Panigada et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Endocrinology & Metabolism

Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients

Zhenzhou Wang et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Review Biochemistry & Molecular Biology

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

Corlia Grobler et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Cell Biology

Innate immune receptors in platelets and platelet-leukocyte interactions

Paula Ribeiro Braga Dib et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Review Pathology

A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Samuel B. Polak et al.

MODERN PATHOLOGY (2020)

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Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

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Article Multidisciplinary Sciences

Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials

Mengjie Zeng et al.

PLOS ONE (2020)

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Editorial Material Medicine, General & Internal

FDA Approval of Remdesivir - A Step in the Right Direction

Daniel Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Integrative & Complementary Medicine

Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective

Suraphan Panyod et al.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2020)

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Meeting Abstract Hematology

The Mystery of Magic Blood - Familial Macrothrombocytopenia Associated with a Novel Variant in GP1BA Gene

Zhaohui Liao Arter et al.

BLOOD (2019)

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Article Multidisciplinary Sciences

Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology

Hongxu Zhu et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Wuwen Feng et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Antoine Daina et al.

SCIENTIFIC REPORTS (2017)

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Article Chemistry, Medicinal

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

Antoine Daina et al.

CHEMMEDCHEM (2016)

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Review Biochemistry & Molecular Biology

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Chaker Aloui et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Review Hematology

The organizing principle of the platelet glycoprotein IbIXV complex

R. Li et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

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Article Immunology

CD154-CD40 Interactions Are Essential for Thymus-Dependent Antibody Production in Zebrafish: Insights into the Origin of Costimulatory Pathway in Helper T Cell-Regulated Adaptive Immunity in Early Vertebrates

Yong-Feng Gong et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Cardiac & Cardiovascular Systems

The CD40/CD40 Ligand System Linking Inflammation With Atherothrombosis

Charalambos Antoniades et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

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Review Immunology

Functional roles for T cell CD40 in infection and autoimmune disease: The role of CD40 in lymphocyte homeostasis

Melissa E. Munroe

SEMINARS IN IMMUNOLOGY (2009)

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Article Hematology

The role of von Willebrand factor in thrombus formation

Zaverio M. Ruggeri

THROMBOSIS RESEARCH (2007)

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Article Chemistry, Medicinal

A bioavailability score

YC Martin

JOURNAL OF MEDICINAL CHEMISTRY (2005)

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Review Cardiac & Cardiovascular Systems

The adhesion molecule P-selectin and cardiovascular disease

AD Blann et al.

EUROPEAN HEART JOURNAL (2003)

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Review Cardiac & Cardiovascular Systems

CD40-CD40L interactions in atherosclerosis

E Lutgens et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2002)

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Article Immunology

CD40/CD40L interaction is essential for the induction of EAE in the absence of CD28-mediated co-stimulation

AM Girvin et al.

JOURNAL OF AUTOIMMUNITY (2002)

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Article Biochemistry & Molecular Biology

Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLeX and PSGL-1

WS Somers et al.

CELL (2000)

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Article Biochemistry & Molecular Biology

The Protein Data Bank

HM Berman et al.

NUCLEIC ACIDS RESEARCH (2000)

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In silico investigation of Panax ginseng lead compounds against COVID-19 associated platelet activation and thromboembolism

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