Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 19, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/ijerph192013101
Keywords
rapid eye movement (REM) sleep; sleep ontogeny; neurodevelopmental disorders; infant; childhood
Funding
- National Natural Science Foundation of China [81771426, 81471347, 31872770, 82001396, 82160267]
- China Scholarship Council [201906185012]
- Talent Introducing Project of State Administration of Foreign Experts Affairs of China [G2022175003L, X2017008]
- programof Gansu Provincial Science and Technology Department [20JR5RA228]
- Fundamental Research Funds for the Central University [lzujbky-2019-cd03, lzujbky-2021-39]
Ask authors/readers for more resources
The study explores the significance of REM sleep in the maturation of the central nervous system, finding that a large amount of REM sleep in early life helps with brain development. It also investigates REM sleep disturbances associated with certain disorders.
The ontogenetic sleep hypothesis suggested that rapid eye movement (REM) sleep is ontogenetically primitive. Namely, REM sleep plays an imperative role in the maturation of the central nervous system. In coincidence with a rapidly developing brain during the early period of life, a remarkably large amount of REM sleep has been identified in numerous behavioral and polysomnographic studies across species. The abundant REM sleep appears to serve to optimize a cerebral state suitable for homeostasis and inherent neuronal activities favorable to brain maturation, ranging from neuronal differentiation, migration, and myelination to synaptic formation and elimination. Progressively more studies in Mammalia have provided the underlying mechanisms involved in some REM sleep-related disorders (e.g., narcolepsy, autism, attention deficit hyperactivity disorder (ADHD)). We summarize the remarkable alterations of polysomnographic, behavioral, and physiological characteristics in humans and Mammalia. Through a comprehensive review, we offer a hybrid of animal and human findings, demonstrating that early-life REM sleep disturbances constitute a common feature of many neurodevelopmental disorders. Our review may assist and promote investigations of the underlying mechanisms, functions, and neurodevelopmental diseases involved in REM sleep during early life.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available