Sepsis among Neonates in a Ghanaian Tertiary Military Hospital: Culture Results and Turnaround Times

In this study, we described the bacterial profile, antibiotic resistance pattern, and laboratory result turnaround time (TAT) in neonates with suspected sepsis from a tertiary-level, military hospital in Accra, Ghana (2017-2020). This was a cross-sectional study using secondary data from electronic medical records. Of 471 neonates clinically diagnosed with suspected sepsis in whom blood samples were collected, the median TAT from culture request to report was three days for neonates who were culture-positive and five days for neonates who were culture-negative. There were 241 (51%) neonates discharged before the receipt of culture reports, and of them, 37 (15%) were culture-positive. Of 471 neonates, twenty-nine percent (n = 139) were bacteriologically confirmed, of whom 61% (n = 85) had late-onset sepsis. Gram-positive bacterial infection (89%, n = 124) was the most common cause of culture-positive neonatal sepsis. The most frequent Gram-positive pathogen was coagulase-negative Staphylococcus (55%, n = 68) followed by Staphylococcus aureus (36%, n = 45), of which one in two were multidrug resistant. The reasons for large numbers being discharged before the receipt of culture reports need to be further explored. There is a need for improved infection prevention and control, along with ongoing local antimicrobial resistance surveillance and antibiotic stewardship to guide future empirical treatment.

Automated summary

This study examined the bacterial profile, antibiotic resistance pattern, and laboratory result turnaround time in neonates with suspected sepsis in a military hospital in Accra, Ghana. The study found that the median turnaround time for culture-positive neonates was three days, while it was five days for culture-negative neonates. Gram-positive bacterial infection, particularly coagulase-negative Staphylococcus and Staphylococcus aureus, were the most common causes of culture-positive neonatal sepsis. There is a need for improved infection prevention and control, along with antimicrobial resistance surveillance and antibiotic stewardship.