Journal
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
Volume 32, Issue 9, Pages 840-844Publisher
JOURNAL MATER SCI TECHNOL
DOI: 10.1016/j.jmst.2016.04.009
Keywords
Gelatin; Dopamine; Doxorubicin; Coordination interaction; Drug delivery
Funding
- AcRF Tier 2 of the Ministry of Education, Singapore [ARC 1/13]
- National Natural Science Foundation of China [51328301]
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In this study, we develop the gelatin-dopamine (Gel-Dopa) nano-gels (GDNGs) and explore their potential as drug delivery vehicles. The Gel-Dopa precursor is synthesized using EDC/NHS coupling reaction, in which the catechols can coordinate with transition metal ions such as Fe3+. These novel GDNGs exhibit excellent cytocompatibility. The model drug, doxorubicin (Dox), is readily conjugated into catechol of GDNGs by the coordination cross-link of Fe3+ ion. The morphology and size distribution of the nano gels are characterized via field emission scanning electron microscopy and particle size analyzer, respectively. The GDNGs loaded with Dox (GDNGs-Dox) is capable of efficiently penetrating cell membrane and enter the HeLa cells. The endocytosed GDNGs-Dox release Dox molecules and subsequently kill the tumor cells. Copyright (C) 2016, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.
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