Journal
CHEMPLUSCHEM
Volume 87, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.202200113
Keywords
copper; liposomes; photodynamic therapy; photothermal therapy; phthalocyanines
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Funding
- National Natural Science Foundation of China [Nos.U1705282, 21473033]
- Natural Science Foundation of Fujian Province, China [2019J01204]
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This work presents the development of a multifunctional thermosensitive liposomal nanoplatform that exhibits both photodynamic and photothermal effects. The nanoplatform enables fluorescence imaging-guided combined cancer treatment and demonstrates significant anticancer efficacy in vivo.
This work reports the development of a multifunctional thermosensitive liposomal nanoplatform (PcS4@Lip-FA) based on a metal-free phthalocyanine modified with tetra-sulfonates (PcPS4), which exhibited photodynamic and photothermal activities simultaneously. Upon irradiation with a near infrared laser, thermosensitive PcS4@Lip-FA could release PcS4 as a result of the local hyperthermia of PcS4. Interestingly, PcS4 could easily chelate with Cu2+, leading to the enhancement of photothermal activity and decrease of photodynamic activity. In addition, in vivo fluorescence imaging revealed that PcS4@Lip-FA could selectively accumulate in tumor tissue of H22 tumor-bearing mice after tail vein injection, and exhibited a significant anticancer phototherapeutic effect, with a tumor inhibition rate of 83.5 %. Therefore, PcPS4@Lip-FA has realized fluorescence imaging-guided combined cancer treatment, providing a promising multifunctional nanoplatform for cancer diagnostics and therapy.
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