Journal
ADVANCED HEALTHCARE MATERIALS
Volume 12, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202200807
Keywords
anti-fibrosis; cochlear implantation; polydopamine; surface modification; zwitterions
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Since the first surgery 50 years ago, cochlear implantation has been the major treatment for severe sensorineural hearing loss. However, foreign body reactions after surgery often lead to fibrosis and residual hearing loss. A zwitterionic coating composed of poly sulfobetaine methacrylate (PSB) and polydopamine (PDA) is developed to inhibit fibrosis and improve the outcomes of cochlear implants.
Since the first surgery 50 years ago, cochlear implantation (CI) is the major treatment for patients with severe sensorineural hearing loss. However, unexpected foreign body reactions (FBRs) after surgery are reported in 90% of CI recipients, resulting in the formation of fibrosis in the cochlea and progressive residual hearing loss. Zwitterion modification is universally used to reduce bio-fouling and suppress FBRs but never for CI. In the present study, a zwitterionic coating is developed, which is composed of poly sulfobetaine methacrylate (PSB) and polydopamine (PDA) for cochlear implants. The PSB-PDA coating shows a series of characters for an ideal anti-FBRs material, including super-hydrophilicity, low protein and cell adsorption, long-term stability, and high biocompatibility. Compared to the uncoated controls, PSB-PDA coating inhibits the activation of macrophages and reduces the release of inflammatory factors (TNF-alpha, IL-1 beta, NO) and fibrosis-related factors (TGF-beta 1, alpha-SMA, collagen I). PSB-PDA coated electrode arrays suppress fibrosis completely and preserve residual hearing significantly in rat CI models. These results suggest that PSB-PDA coating is a novel strategy for anti-fibrosis to improve the outcomes of CI.
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