Journal
SCIENTIFIC REPORTS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-20880-7
Keywords
-
Categories
Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada [RGPIN-2014-04586]
- Canada Foundation for Innovation
- Calgary Foundation, Grace Glaum Professorship
- Canadian Institutes for Health Research [01309MOP-311542-DIB-CBBA-170939]
Ask authors/readers for more resources
Juvenile idiopathic arthritis patients' synovial derived mesenchymal stem/progenitor cells (MPCs) have reduced self-renewal ability and chondrogenic differentiation capacity, and cannot induce cartilage regeneration. These findings may have implications for future cell therapy strategies.
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases affecting joints with a prevalence of one in a thousand children. There is a growing body of literature examining the use of mesenchymal stem/progenitor cells (MPCs) for the treatment of adult and childhood arthritis, however, we still lack a clear understanding of how these MPC populations are impacted by arthritic disease states and how this could influence treatment efficacy. In the current study we examined the immunophenotyping, self-renewal ability and chondrogenic capacity (in vitro and in vivo) of synovial derived MPCs from normal, JIA and RA joints. Synovial MPCs from JIA patients demonstrated reduced self-renewal ability and chondrogenic differentiation capacity. Furthermore, they did not induce cartilage regeneration when xenotransplanted in a mouse cartilage injury model. Synovial MPCs from JIA patients are functionally compromised compared to MPCs from normal and/or RA joints. The molecular mechanisms behind this loss of function remain elusive. Further study is required to see if these cells can be re-functionalized and used in cell therapy strategies for these JIA patients, or if allogenic approaches should be considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available