4.7 Article

Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats

Tabitha R. F. Green et al.

Summary: This study examined the glial response to traumatic brain injury (TBI) and found that rats injured at a younger age (PND17) exhibited a stronger glial response compared to rats injured at an older age (PND35). Furthermore, this response persisted into early adulthood.

FRONTIERS IN NEUROLOGY (2022)

Article Biology

Microglia Are Necessary to Regulate Sleep after an Immune Challenge

Rachel K. Rowe et al.

Summary: Microglia are found to play a critical role in regulating sleep after an immune challenge. Depletion of microglia results in increased sleep following an inflammatory injection, while repopulation of microglia leads to changes in sleep patterns. This study suggests that microglia are necessary for sleep regulation after inflammation.

BIOLOGY-BASEL (2022)

Article Neurosciences

Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia

Kristina G. Witcher et al.

Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.

JOURNAL OF NEUROSCIENCE (2021)

Article Cell Biology

Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron Apoptosis via EZH2-Downregulated KLF4/p38 Axis

Zhongyu Wang et al.

Summary: Sevoflurane has been shown to reduce neuron apoptosis in traumatic brain injury (TBI) by activating the p38-MAPK signaling pathway through the EZH2/KLF4 axis, providing a novel mechanistic explanation for the neuroprotective effects of sevoflurane in TBI.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Variability in the analysis of a single neuroimaging dataset by many teams

Rotem Botvinik-Nezer et al.

NATURE (2020)

Article Endocrinology & Metabolism

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke

Wenjun Deng et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

Review Health Care Sciences & Services

A review of spline function procedures in R

Aris Perperoglou et al.

BMC MEDICAL RESEARCH METHODOLOGY (2019)

Article Mathematical & Computational Biology

Quantifying How Staining Methods Bias Measurements of Neuron Morphologies

Roozbeh Farhoodi et al.

FRONTIERS IN NEUROINFORMATICS (2019)

Article Multidisciplinary Sciences

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

Kimberly Young et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Article Multidisciplinary Sciences

Simultaneous Cryosectioning of Multiple Rodent Brains

Tabitha R. F. Green et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Article Neurosciences

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis

Maria del Mar Fernandez-Arjona et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

Benjamin M. Davis et al.

SCIENTIFIC REPORTS (2017)

Article Computer Science, Interdisciplinary Applications

glmmTMB Balances Speed and Flexibility Among Packages for Zero-inflated Generalized Linear Mixed Modeling

Mollie E. Brooks et al.

R JOURNAL (2017)

Article Immunology

Morphometric characterization of microglial phenotypes in human cerebral cortex

Susana G. Torres-Platas et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Editorial Material Multidisciplinary Sciences

NIH plans to enhance reproducibility

Francis S. Collins et al.

NATURE (2014)

Article Immunology

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

Helena W. Morrison et al.

JOURNAL OF NEUROINFLAMMATION (2013)

Review Neurosciences

Quantitating the subtleties of microglial morphology with fractal analysis

Audrey Karperien et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2013)

Article Statistics & Probability

New Effect Size Rules of Thumb

Shlomo S. Sawilowsky

JOURNAL OF MODERN APPLIED STATISTICAL METHODS (2009)

Article Neurosciences

Fractality of dendritic arborization of spinal cord neurons

NT Milosevic et al.

NEUROSCIENCE LETTERS (2006)

Article Neurosciences

ATP mediates rapid microglial response to local brain injury in vivo

D Davalos et al.

NATURE NEUROSCIENCE (2005)

Article Multidisciplinary Sciences

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

A Nimmerjahn et al.

SCIENCE (2005)

Article Statistics & Probability

Beta regression for modelling rates and proportions

SLP Ferrari et al.

JOURNAL OF APPLIED STATISTICS (2004)

Article Computer Science, Cybernetics

Fractal and nonfractal analysis of cell images: comparison and application to neuronal dendritic arborization

D Ristanovic et al.

BIOLOGICAL CYBERNETICS (2002)